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中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (03) : 217 -221. doi: 10.3877/cma.j.issn.1647-0793.2013.03.014

所属专题: 文献

综述

胃食管反流病发病机制研究进展
房俊1, 杨晓俊1, 喻春钊1, 张建平1,()   
  1. 1. 210011,南京医科大学第二附属医院普外科
  • 收稿日期:2012-11-05 出版日期:2013-06-01
  • 通信作者: 张建平
  • 基金资助:
    国家自然科学基金青年基金(81100253)

Progress in the pathogenesis of gastroesophageal reflux disease

Jun FANG1, Xiao-jun YANG1, Chun-zhao YU1, Jian-ping ZHANG1,()   

  1. 1. Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
  • Received:2012-11-05 Published:2013-06-01
  • Corresponding author: Jian-ping ZHANG
  • About author:
    Corresponding author: ZHANG Jian-ping, Email:
引用本文:

房俊, 杨晓俊, 喻春钊, 张建平. 胃食管反流病发病机制研究进展[J]. 中华普通外科学文献(电子版), 2013, 07(03): 217-221.

Jun FANG, Xiao-jun YANG, Chun-zhao YU, Jian-ping ZHANG. Progress in the pathogenesis of gastroesophageal reflux disease[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 217-221.

胃食管反流病(GERD)是指上消化道内容物反流进入食管引起的疾病,患者可以出现食管内及食管外症状,如胸部烧灼感(烧心)、反流、顽固性的咳嗽等。GERD的发病机制与抗反流屏障功能下降、反流物的攻击作用、幽门螺杆菌(Hp)感染、Cajal间质细胞(ICC)数量减少或功能障碍、内脏敏感性增高等有关。

Gastroesophageal reflux disease (GERD) is a condition which develops when contents of upper gastrointestinal tract reflux into the esophagus, causing injury to esophageal tissue or symptoms, such as heartburn, regurgitation, chronic cough. The pathogenesis of GERD is related with damage of the antireflux barrier, attack of the refluxate, the Helicobacter pylori(Hp) infection, reduced and dysfunction of Cajal cells and so on.

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