切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (03) : 217 -221. doi: 10.3877/cma.j.issn.1647-0793.2013.03.014

所属专题: 文献

综述

胃食管反流病发病机制研究进展
房俊1, 杨晓俊1, 喻春钊1, 张建平1,()   
  1. 1. 210011,南京医科大学第二附属医院普外科
  • 收稿日期:2012-11-05 出版日期:2013-06-01
  • 通信作者: 张建平
  • 基金资助:
    国家自然科学基金青年基金(81100253)

Progress in the pathogenesis of gastroesophageal reflux disease

Jun FANG1, Xiao-jun YANG1, Chun-zhao YU1, Jian-ping ZHANG1,()   

  1. 1. Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
  • Received:2012-11-05 Published:2013-06-01
  • Corresponding author: Jian-ping ZHANG
  • About author:
    Corresponding author: ZHANG Jian-ping, Email:
引用本文:

房俊, 杨晓俊, 喻春钊, 张建平. 胃食管反流病发病机制研究进展[J/OL]. 中华普通外科学文献(电子版), 2013, 07(03): 217-221.

Jun FANG, Xiao-jun YANG, Chun-zhao YU, Jian-ping ZHANG. Progress in the pathogenesis of gastroesophageal reflux disease[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 217-221.

胃食管反流病(GERD)是指上消化道内容物反流进入食管引起的疾病,患者可以出现食管内及食管外症状,如胸部烧灼感(烧心)、反流、顽固性的咳嗽等。GERD的发病机制与抗反流屏障功能下降、反流物的攻击作用、幽门螺杆菌(Hp)感染、Cajal间质细胞(ICC)数量减少或功能障碍、内脏敏感性增高等有关。

Gastroesophageal reflux disease (GERD) is a condition which develops when contents of upper gastrointestinal tract reflux into the esophagus, causing injury to esophageal tissue or symptoms, such as heartburn, regurgitation, chronic cough. The pathogenesis of GERD is related with damage of the antireflux barrier, attack of the refluxate, the Helicobacter pylori(Hp) infection, reduced and dysfunction of Cajal cells and so on.

1
Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol, 2009, 44(6): 518-534.
2
Pandeya N, Webb PM, Sadeghi S, et al. Australian Cancer Study.Gastro-oesophageal reflux symptoms and the risks of oesophageal cancer: are theeffects modified by smoking, NSAIDs or acid suppressants? Gut, 2010, 59(1): 31-38.
3
Dent J, El-Serag HB, Wallander MA, et al. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut, 2005, 54(5): 710-717.
4
Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol, 2006, 4(4): 398-407.
5
Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology, 2002, 122(5): 1500-1511.
6
Wu JC. Gastroesophageal reflux disease: an Asian perspective. J Gastroenterol Hepatol, 2008, 23(12): 1785-1793.
7
Tsuboi K, Hoshino M, Sundaram A, et al. Role of the lower esophageal sphincter on esophageal acid exposure - a review of over 2000 patients. Trop Gastroenterol, 2012, 33(2): 107-111.
8
Navarro-Rodriguez T, Hashimoto CL, Carrilho FJ, et al. Reduction of abdominal pressure in patients with ascites reducesgastroesophageal reflux. Dis Esophagus, 2003, 16(2): 77-82.
9
宁雅婵,汪忠镐,吴继敏, 等. 胃食管反流病1014例住院患者的诊治分析[J/CD]. 中华普外科手术学杂志:电子版, 2010, 4(3): 264-270.
10
van Wijk MP, Blackshaw LA, Dent J, et al. Distension of the esophagogastric junction augments triggering of transient lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol, 2011, 301(4): G713-718.
11
Pandolfino JE, Kim H, Ghosh SK, et al. High-resolution manometry of the EGJ: an analysis of crural diaphragm function in GERD. Am J Gastroenterol, 2007, 102(5): 1056-63.
12
Daes J, Jimenez ME, Said N, et al. Laparoscopic Sleeve Gastrectomy: Symptoms of Gastroesophageal Reflux can be Reduced by Changes in Surgical Technique. Obes Surg, 2012, 22(12): 1874-9.
13
Savarino E, Gemignani L, Pohl D, et al. Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease. Aliment Pharmacol Ther, 2011, 34(4): 476-486.
14
de Miranda Gomes PR Jr, Pereira da Rosa AR, Sakae T, et al. Correlation between pathological distal esophageal acid exposure and ineffective esophageal motility. Acta Chir Iugosl, 2010, 57(2): 37-43.
15
祁小鸣,陈恕之,周步良, 等. 老年人反流性食管炎临床特点分析. 胃肠病学和肝病学杂志, 2012, 21(10): 933-935.
16
Chen CL, Yi CH, Liu TT, et al. Altered sensorimotor responses to esophageal acidification in older adults with GERD. Scand J Gastroenterol, 2010, 45(10): 1150-1155.
17
Inci K, Edebo A, Olbe L, et al. Expression of protease-activated-receptor 2 (PAR-2) in human esophageal mucosa. Scand J Gastroenterol, 2009, 44(6): 664-671.
18
Kandulski A, Wex T, Mönkemüller K, et al. Proteinase-activated receptor-2 in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol, 2010, 105(9): 1934-1943.
19
Mokrowiecka A, Wierzchniewska-Ławska A, Smolarz B, et al. Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Pol Merkur Lekarski, 2009, 26(155): 385-389.
20
Vela MF, Craft BM, Sharma N, et al. Refractory heartburn: comparison of intercellular space diameter in documented GERD vs. functional heartburn. Am J Gastroenterol, 2011, 106(5): 844-850.
21
邹方明,庄则豪. 胃食管反流病发病机制研究进展[J/CD]. 中华临床医师杂志:电子版, 2011, 5(23): 7035-7037.
22
Jovov B, Que J, Tobey NA, et al. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol, 2011, 106(6): 1039-1047.
23
Ang D, Blondeau K, Sifrim D, et al. The spectrum of motor function abnormalities in gastroesophageal reflux disease and Barrett's esophagus. Digestion, 2009, 79(3): 158-168.
24
Leahy A, Besherdas K, Clayman C, et al. Gastric dysrhythmias occur in gastro-oesophageal reflux disease complicated by food regurgitation but not in uncomplicated reflux. Gut, 2001, 48(2): 212-215.
25
Ianova OB, Vasnev OS. Results of 24-h pH monitoring in patients with gastroesophageal reflux disease before and after fundoplication. Ter Arkh, 2011, 83(4): 36-39.
26
Kunsch S, Neesse A, Linhart T, et al. Prospective Evaluation of Duodenogastroesophageal Reflux in Gastroesophageal Reflux Disease Patients Refractory to Proton Pump Inhibitor Therapy. Digestion, 2012, 86(4): 315-322.
27
Ashktorab H, Entezari O, Nouraie M, et al. Helicobacter pylori Protection Against Reflux Esophagitis. Dig Dis Sci, 2012, 57(11): 2924-2928.
28
Wu JC, Cheung CM, Wong VW, et al. Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. Clin Gastroenterol Hepatol, 2007, 5(6): 690-695.
29
Rodrigues L Jr, Faria CM, Geocze S, et al. Helicobacter pylori eradication does not influence gastroesophageal reflux disease: a prospective, parallel, randomized, open-label, controlled trial. Arq Gastroenterol, 2012, 49(1): 56-63.
30
Canning BJ, Mori N, Lehmann A. Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: Comparison to baclofen and other GABAB receptor-selective agonists. Cough, 2012, 8(1): 7.
31
Shafik A, Ahmed I, El Sibai O, et al. Interstitial cells of cajal in reflux esophagitis: role in the pathogenesis of the disease. Med Sci Monit, 2005, 11(12): BR452-456.
32
Lagraize SC, Guo W, Yang K, et al. Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience, 2010, 171(4): 1341-1356.
33
Dickman R, Pastricha PJ, Winston J, et al. Patients with non- erosive reflux disease (NERD) demonstrate upregulation of TRPV1 receptors in the distal esophagus as compared to the other GERD groups. Gastroenterology, 2006, 4(Suppl 2): M2002.
34
孟庆伟,许树长. 食管内脏高敏感及其相关研究进展. 世界华人消化杂志, 2012, 20(7): 568-573.
35
Mohammed I, Cherkas LF, Riley SA, et al. Genetic influences in gastro-oesophageal reflux disease: a twin study. Gut, 2003, 52(8): 1085-1089.
36
Cheng HH, Chang CS, Wang HJ, et al. Interleukin-1beta and -10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients. J Gastroenterol Hepatol, 2010, 25(8): 1443-1451.
[1] 邢益民, 张天飞, 戴慧勇. 胃肠充盈超声造影检查在反酸、嗳气患者临床诊断中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(03): 303-306.
[2] 李海云, 赵敏娴, 申英末, 杨慧琪. 胃底折叠术预防食管裂孔疝术后并发症的研究进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 485-490.
[3] 玉素江·图荪托合提, 韩琦, 麦麦提艾力·麦麦提明, 黄旭东, 王浩, 克力木·阿不都热依木, 艾克拜尔·艾力. 腹腔镜袖状胃切除或联合食管裂孔疝修补术对肥胖症合并胃食管反流病的中期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 501-506.
[4] 任传富, 杨志, 徐恩, 何梓芸, 罗板鑫, 陈新, 夏雪峰. 腹腔镜疝修补术联合胃底折叠术治疗食管裂孔疝合并胃食管反流病40 例临床分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 507-511.
[5] 刘璐璐, 何羽. 慢性阻塞性肺病患者睡眠障碍的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 836-839.
[6] 廖江荣, 吴秀琳, 陈光春, 郭亮, 吕慈, 蔡俊, 陈夕. 急性主动脉夹层并发急性肺损伤的研究新进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 488-492.
[7] 胡志伟, 吴继敏, 邓昌荣, 战秀岚, 纪涛, 王峰, 田书瑞, 陈冬, 张玉, 刘健男, 宋庆. 抗反流黏膜套扎治疗顽固性胃食管反流病[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(04): 227-233.
[8] 赵静, 张嘉欣, 高言, 谢席胜. 微小病变肾病的发病机制及治疗研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(04): 207-212.
[9] 孙鼎, 王滨, 陈香美, 陈意志. 热应激肾病的研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(03): 170-176.
[10] 贾红艳, 王丹, 张冉冉, 马茜, 焦永红. 基于全外显子组测序探寻Möbius综合征发病机制的遗传学研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 146-154.
[11] 曹文钰, 郭鹏, 李锦平. 微创手术及非手术方式治疗慢性硬膜下血肿的研究进展[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 304-309.
[12] 唐小久, 胡曼, 许必君, 肖亚. 肥胖合并胃食管反流病患者严重程度与其焦虑抑郁及营养状态的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 360-364.
[13] 安亚楠, 王端然, 郭甜甜, 武希润. 幽门螺杆菌阴性胃黏膜相关淋巴组织淋巴瘤的研究进展[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(03): 268-274.
[14] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[15] 中国医师协会外科医师分会肥胖和代谢病外科专家工作组, 中国医师协会外科医师分会胃食管反流疾病诊疗外科专家工作组, 日本肥胖治疗学会, 韩国减重与代谢外科学会. 袖状胃切除术患者胃食管反流病诊治专家共识(2024版)[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 145-162.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?