中华普通外科学文献(电子版) ›› 2008, Vol. 02 ›› Issue (04) : 291 -293. doi: 10.3877/cma.j.issn.1674-0793.2008.04.010
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Bing-zong HOU1, Shao-peng ZHOU1, Si-lian FANG,1, Xiao-ling LI1, Xiang-qong MO1
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侯冰宗, 周少朋, 房思炼, 李霄凌, 莫湘琼. 开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移的临床观察[J/OL]. 中华普通外科学文献(电子版), 2008, 02(04): 291-293.
Bing-zong HOU, Shao-peng ZHOU, Si-lian FANG, Xiao-ling LI, Xiang-qong MO. Clinical study on chronomodulated chemotherapy of irinotecan combined with 5-FU and CF on colorectal carcinoma patients with hepatic metastasis[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(04): 291-293.
目的
观察开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移临床疗效及毒副作用。
方法
大肠癌手术后肝转移患者28例，随机分为A、B两组进行化疗，方案为：开普拓、5-氟尿嘧啶、亚叶酸钙，A组按时辰给药法治疗，B组按常规给药法治疗，按WHO标准观察两组患者的近期疗效及不良反应。
结果
A组有效率（CR+PR）为78.5%，B组为35.7%，A组与B组相比较差异有显著性意义（P＜0.01），A组对化疗药物的毒副反应均较B组轻，A、B两组Ⅲ/Ⅳ度中性粒细胞减少、腹泻、脱发的发生率相比较差异均有显著性意义（P<0.05）。
结论
开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗作为一种新的给药方式进行大肠癌肝转移化疗，具有较好的临床疗效及较低的毒副反应。
Objective
To evaluate the clinical efficacy and the adverse drug reactions of chronomodulated chemotherapy of irinotecan(CPT-11)combined with 5-fluorouracil(5-FU)and calcium folinate(CF)on colorectal carcinoma patients with hepatic metastasis.
Methods
28 colorectal carcinoma patients with hepatic metastasis were divided into group A and B. group A were employed the chronomodulated chemotherapy of CPT-11 combined with 5-FU and CF procedure,while group B used the CPT-11combined with 5-FU and CF rountinly. The short term efficacy and adverse drug reactions were evaluated according to the standard by WHO.
Results
The higher percentages of clinical efficacy clinical efficacy(CR+PR)was A,78.5%vs B,35.7%and the lower percentages of adverse drug reactions occurred in group A (P<0.05).
Conclusion
Chronomodulated chemotherapy of CPT-11 combined with 5-FU and CF may be more effective and may cause the lower adverse drug reactions on colorectal carcinoma with hepatic metastasis.