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中华普通外科学文献(电子版) ›› 2009, Vol. 03 ›› Issue (02) : 50 -52. doi: 10.3877/cma.j.issn.1674-0793.2009.02.019

讲座与综述

胸苷磷酸化酶与肝癌血管生成相关性的研究进展
韩绍腾1, 戴朝六1   
  1. 1.110004 沈阳,中国医科大学附属盛京医院肝胆乳腺外科
  • 收稿日期:2008-12-02 出版日期:2009-04-01

Shao-teng HAN, Zhao-liu DAI   

  • Received:2008-12-02 Published:2009-04-01
引用本文:

韩绍腾, 戴朝六. 胸苷磷酸化酶与肝癌血管生成相关性的研究进展[J]. 中华普通外科学文献(电子版), 2009, 03(02): 50-52.

Shao-teng HAN, Zhao-liu DAI. [J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(02): 50-52.

胸苷磷酸化酶(TP)是一种血管生长因子,与肝癌血管生成密切相关。近年来,在促进肿瘤生长、预测肿瘤患者生存期及化疗效果方面的作用日益受到关注。TP通过增加肿瘤基质中的微血管密度(MVD),促进肿瘤生长和转移。患者的肿瘤切除标本中TP的表达程度与患者的肿瘤复发率、转移率呈正相关,与生存率呈负相关。希罗达的广泛使用证实TP能增加氟尿嘧啶类化疗药物的抗肿瘤疗效。本文就这些方面的研究进展做一综述。

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