切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2009, Vol. 03 ›› Issue (02) : 50 -52. doi: 10.3877/cma.j.issn.1674-0793.2009.02.019

讲座与综述

胸苷磷酸化酶与肝癌血管生成相关性的研究进展
韩绍腾1, 戴朝六1   
  1. 1.110004 沈阳,中国医科大学附属盛京医院肝胆乳腺外科
  • 收稿日期:2008-12-02 出版日期:2009-04-01

Shao-teng HAN, Zhao-liu DAI   

  • Received:2008-12-02 Published:2009-04-01
引用本文:

韩绍腾, 戴朝六. 胸苷磷酸化酶与肝癌血管生成相关性的研究进展[J/OL]. 中华普通外科学文献(电子版), 2009, 03(02): 50-52.

Shao-teng HAN, Zhao-liu DAI. [J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(02): 50-52.

胸苷磷酸化酶(TP)是一种血管生长因子,与肝癌血管生成密切相关。近年来,在促进肿瘤生长、预测肿瘤患者生存期及化疗效果方面的作用日益受到关注。TP通过增加肿瘤基质中的微血管密度(MVD),促进肿瘤生长和转移。患者的肿瘤切除标本中TP的表达程度与患者的肿瘤复发率、转移率呈正相关,与生存率呈负相关。希罗达的广泛使用证实TP能增加氟尿嘧啶类化疗药物的抗肿瘤疗效。本文就这些方面的研究进展做一综述。

1
Furukawa T,Yoshimura A,Sumizawa T,et al.Angiogenic factor.Nature,1992,356(6371): 668.
2
Sumizawa T,Furukawa T,Haraguchim M,et al.Thymidine phosphorylase activity with platelet-derived endothelial cell growth factor. J Biochem,1993,114(1):9-14.
3
Miyadera K, Dohmae N, Takio K, et al. Structural of characterization thymidine phosphorylase purled from human placenta.Biochem Biophys Res Commun,1995,212(3):1040-1045.
4
肖永胜,周俭,汤钊猷,等.干扰素诱导人肝细胞癌胸苷磷酸化酶表达和拮抗血管生成的实验研究.中华医学杂志,2005,85(45):3205-3209.
5
肖永胜,汤钊猷,樊嘉,等.转染胸苷磷酸化酶基因对肝癌细胞的双重影响.中华实验外科杂志,2004,21(9):1053-1055.
6
Focher F,Ubiali D,Pregnolato M,et al.Novel nonsubstrate inhibitors of human thymidine phosphorylase,a potential target for tumor-dependent angiogenesis.J Med Chem,2000,43(3):2601-2607.
7
Yoshimura a,Kuwauru Y,Furukawa T,et al.Purification and tissue distribution of human thymidine phosphorylase;high expression in lymphoeytes and tumors.Biachem Biophy Acta,1990,1034(1):107-113.
8
Folkman J.What is the evidence that tumors are angiogenesis dependent?J Natl Cancer Inst,1990,82(1):4-6.
9
宋修峰,王滨,高志芹,等.胸苷磷酸化酶在肝细胞癌中的表达及临床意义.天津医科大学学报,2006,12(2):229-231.
10
Takebayashi Y, Miyadera K, Akiyama S, et al. Expression of thymidine phosphorylase in human gastric carcinoma. Jpn J Cancer Res,1996,87(3):288-295.
11
Miyadera K,Sumizawa T,Haraguehi M,et al.Role of thymidine phos phorylase activity in the angiogenic effect of plateletderived endothelial cell growth factor/thymidine phosphorylase. Cancer Research,1995,55(8):1687-1690.
12
Stevenson DP,Milligan SR,Collins WP,et al.Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase,substrate,and products in a three-dimensional model of angiogenesis. Am J Pathol,1998,152(6):1641-1646.
13
Brown NS, Jones A, Fujiyama C, et al. Thymidine phosphorylase induce carcinoma cell oxidative stress and promotes secretion of angiogenic factors.Cancer Research,2000,60(22):6298-6302.
14
Moghaddam A,Zhang HT, Fan TP, t a1. Thymidine phosphorylase is angiogenic and promotes tumor growth.Proe Natl Acad Sci USA,1995,99(4):998-1002.
15
Takebayashi Y, Akiyama S, Akiba S, et al. Clinicopathologic and prognostic significance of an angiogenic factor,thymidine phosphorylase,in human colorectal carcinoma.J Natl Cancer last,1996,88(16):1110-1117.
16
Koide N, Watanabe H, Yazawa K, et al. Immunohistochemical expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in squamous cell carcinoma of the esophagus.Hepato Gastroenterology,1999,46(26):944-951.
17
Kikuyama S,Inada T,Shimizu K,et al.Thymidine phosphorylase expression in gastric cancer in association with proliferative activity and an~ogenesis.Anticancer Res,2000,20(3B):2081-2086.
18
Konno S, Takebayashi Y, Aibac M, et al. Clinicopathological and prognostic significance of thymidine phosphorylase and proliferating cell nuclear antigen in gastric carcinoma. Cancer Lett, 2001, 166(1):103-111.
19
Kitazono M,Takebayashi Y,Ishitsuka K,et al. Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase.Biochem Biophy Res commun.1998,253(3):797-803.
20
Ikeda R,Furukawa T,Kitazono M,et al.Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-diribose. Biochem Bioph Res commun,2002,291(4):806-812.
21
Maeda K, Chung Y-S, Ogawa S, et al. Thymidine phosphorylase/plateletderived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma.Br J Cancer,1996,73(8):884-888.
22
Ueda M, Terai Y, Kumagai K, et al. Correlation between thymidine phosphorylase expression and invasion phenotype in cervical carcinoma cells.Int J Cancer,2001,91(6):778-782.
23
Ezaki T, Ikegami T, Maeda T, et al. Prognostic value of thymidine phosphorylase activity in liver tissue adjacent to hepatocellular carcinoma.Int J Oncol(2005)10:171-176.
24
Patterson AV,Zhang H, Moghaddam A, et al. Increased sensitivity to the predrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2' deoxyuridine sensitivity in MCF-7721 cells transfected with thymldine phosphorylase.Br J Cancer,72(3):669-675.
25
Cassidy J, Dirix L, Bissett D, et al. A phase I study of capecitabin in combination with oral leucovorin in patients with intractable solid tumors.Clin Cancer Res,1998,4(11):2755-2761.
26
Ishikawa T, Utoh M, Sawads N, et al. Tumor selective delivery of 5-fluorouracil by capecitabine,a new oral fluoropyrimidine carbamate, in human cancer xenografts. Biochem Pharmaeol, 1998, 55(7):1091-1097.
27
Mori K,Hasegawa M,Nishida M,et al.Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues.Int Oncol,2000,17(1):33-38.
[1] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[2] 高俊颖, 张海洲, 区泓乐, 孙强. FOLFOX-HAIC 为基础的肝细胞癌辅助转化治疗的应用进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(06): 457-463.
[3] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[4] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[5] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[6] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[7] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[8] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[9] 赖全友, 高远, 汪建林, 屈士斌, 魏丹, 彭伟. 三维重建技术结合腹腔镜精准肝切除术对肝癌患者术后CD4+、CD8+及免疫球蛋白水平的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 651-654.
[10] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[11] 顾雯, 凌守鑫, 唐海利, 甘雪梅. 两种不同手术入路在甲状腺乳头状癌患者开放性根治性术中的应用比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 687-690.
[12] 李伟, 宋子健, 赖衍成, 周睿, 吴涵, 邓龙昕, 陈锐. 人工智能应用于前列腺癌患者预后预测的研究现状及展望[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 541-546.
[13] 陈樽, 王平, 金华, 周美玲, 李青青, 黄永刚. 肌肉减少症预测结直肠癌术后切口疝发生的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 639-644.
[14] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[15] 郭曌蓉, 王歆光, 刘毅强, 何英剑, 王立泽, 杨飏, 汪星, 曹威, 谷重山, 范铁, 李金锋, 范照青. 不同亚型乳腺叶状肿瘤的临床病理特征及预后危险因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 524-532.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?