目的

探讨乳腺硬化性腺病的临床特征、病理诊断要点和治疗方法，为该疾病的正确诊断及治疗提供参考。

方法

通过对中山大学附属第三医院及附属第一医院近15年收治的8例硬化性腺病的临床特点、常规HE染色和免疫组化进行临床病理分析，结合其临床表现、影像学表现及外科治疗方法进行探讨。

结果

8例患者B超、钼靶均未能正确诊断，5例患者标本的病理形态与乳腺癌较为相似，需要经免疫组化方能鉴别。1例不能触及肿物的患者经钼靶下钢丝定位获得准确、完整切除。全部病灶经过手术切除，随访0.5～4.0年均无复发。

结论

B超、钼靶等影像学方法对于诊断硬化性腺病的敏感性较差；免疫组化染色肌上皮标记SMA、P63是鉴别乳腺硬化性腺病与乳腺癌的重要指标；对于不能触及病变的硬化性腺病可采用钼靶摄片下钢丝定位后外科切除。

Objective

To investigate the clinicopathological features,main points of diagnosis and antidiastole,andtherapyofbreastsclerosingadenosis,providingareferencefortherightdiagnosisandtreatment.

Methods

Depending on the clinicopathological features,routine HE staining,immunohistochemistry (IHC), clinical characteristics,imageological appearance,the surgical therapy of 8 cases with breast bclerosing adenosis were analyzed during the past 15 years in the third and first affiliated hospital of SUN Yat-sen university.

Results

Eight patients could not be correctly diagnosed by ultralsound and mammogram.The pathological appearance of 5 patients were similar to tubular cancer,and needed IHC to discriminate.One patient with non-palpable breast lesion were operated accurately with the guide wire localization under molybdenum target.All lesions were removed with no recurrence after followed up for 0.5-4.0 years.

Conclusions

Imageological methods,such as ultrasound and molybdenum tarsget are not sensitive for the diagnosis of breast sclerosing adenosis.IHC staining of myoepitheliumis an important for the diagnosis of breast sclerosing adenosis demarcated with breast cancer.Non-palpable lesion of breastsclerosing adenosis can be surgically exsected with the guide wire localization under molybdenum target.