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中华普通外科学文献(电子版) ›› 2009, Vol. 03 ›› Issue (05) : 31 -33. doi: 10.3877/cma.j.issn.1674-0793.2009.05.010

论著

乳腺癌新辅助化疗对拓扑异构酶Ⅱα表达的影响
董苑1, 朱易凡1, 李松奇1,()   
  1. 1.510080 广州,中山大学附属第一医院乳腺疾病中心
  • 收稿日期:2009-03-16 出版日期:2009-10-01
  • 通信作者: 李松奇

Expression of topoisomerase Ⅱα in breast cancer neoadjuvant chemotherapy patients

Yuan DONG1, Yi-fan ZHU1, Song-qi LI1,()   

  1. 1.Department of Vascular Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080,China.
  • Received:2009-03-16 Published:2009-10-01
  • Corresponding author: Song-qi LI
引用本文:

董苑, 朱易凡, 李松奇. 乳腺癌新辅助化疗对拓扑异构酶Ⅱα表达的影响[J]. 中华普通外科学文献(电子版), 2009, 03(05): 31-33.

Yuan DONG, Yi-fan ZHU, Song-qi LI. Expression of topoisomerase Ⅱα in breast cancer neoadjuvant chemotherapy patients[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(05): 31-33.

目的

探讨乳腺癌新辅助化疗对拓扑异构酶Ⅱα(TopoⅡα)表达的影响,评价TopoⅡα对蒽环类化疗敏感性的预测意义。

方法

应用免疫组化Envision两步染色法检测48例乳腺癌患者新辅助化疗前后乳腺癌组织中TopoⅡα表达情况,统计分析TopoⅡα化疗前后的改变及其与临床资料的关系,以及TopoⅡα表达和ER、PR、CerbB2各指标表达的相关性。

结果

经蒽环类化疗后TopoⅡα表达降低有统计学意义。化疗前TopoⅡα高表达及化疗后TopoⅡα表达降低与化疗效果相关。

结论

TopoⅡα是乳腺癌蒽环类化疗敏感的有效预测指标。

Objective

To investigate the relationship between the expression of topoisomerase Ⅱα in breast cancer patient and to evaluate the role of topoisomerase Ⅱα as a predictor of clinical response (CR and PR)after anthracycline-based chemotherapy for breast cancer.

Methods

forty-eight breast cancer patients receiving anthracycline-based neoadjuvant chemotherapy were restrospectively studied.Core biopsy samples before the chemotherapy and surgical samples were obtained for assay of topoisomerase Ⅱα expression.

Results

The expression of TopoⅡα decreased after chemotherapy.Overexpression of TopoⅡα before chemotherapy and the decreasing after chemotherapy was associated with better pathologic response.

Conclusions

We confirmed the predictive value of topoisomerase IIα for clinical response after anthracycline-based chemotherapy.

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