切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2010, Vol. 04 ›› Issue (05) : 491 -494. doi: 10.3877/cma.j.issn.1674-0793.2010.05.027

所属专题: 文献

讲座与综述

肝干细胞与肝癌干细胞相关研究进展
程志祥1, 汪谦1   
  1. 1. 510080 广州,中山大学附属第一医院肝胆外科
  • 收稿日期:2010-02-08 出版日期:2010-10-01
  • Received:2010-02-08 Published:2010-10-01
引用本文:

程志祥, 汪谦. 肝干细胞与肝癌干细胞相关研究进展[J]. 中华普通外科学文献(电子版), 2010, 04(05): 491-494.

肿瘤是一种干细胞疾病,这一理论目前得到广泛认可,越来越多的研究也显示了干细胞与肝癌发生间的密切关系。肝癌恶性程度高,疗效差,研究干细胞在肝癌中的作用有望从根本上改变肝癌的诊疗方法和疗效。本文就干细胞在肝癌中的相关研究进展作一综述。

1
Ischenko I,Seeliger H,Kleespies A, et al. Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications. Langenbecks Arch Surg, 2010, 395(1): 1-10.
2
Er O. Cancer Stem Cells in Solid Tumors. Oncology, 2009, 32(10): 605-609.
3
Li H,Li X,Lam KS, et al. Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. J Biomed Sci, 2008, 15(4): 487-497.
4
Mancino MG,Carpino G,Onori P, et al. Hepatic "stem" cells: state of the art. Ital J Anat mbryol, 2007, 112(2): 93-109.
5
Roskams T. Different types of liver progenitor cells and their niches. Hepatology, 2006, 45(1): 1-4.
6
Shafritz DA,Oertel M,Menthena A, et al. Liver stem cells and prospects for liver constitution by transplanted cells. Hepatology, 2006, 43(2): S89-S98.
7
Yovchev MI,Zhang J,Neufeld DS, et al. Thymus cell antigen-1-expressing cells in the oval cell compartment. Hepatology, 2009, 50(2): 601-611.
8
Virginie P,Nicolas F. Origin of small hepatocyte-like progenitor in retrorsine-treated rats. J Hepatol, 2008, 48(2): 368-369.
9
Best DH,Coleman WB. Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. J Hepatol, 2007, 46(6): 1055-1063.
10
Johnnidis JB,Camargo FD. Isolation and functional characterization of side population stem cells. Methods Mol Biol, 2008, 430: 183-193.
11
Chiba T,Kita K,Zheng YW, et al. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology, 2006, 44(1): 240-251.
12
Fan J,Li R,Zhang R, et al. Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells. World J Gastroenterol, 2007, 13(45): 6053-6059.
13
Tavaluc RT,Hart LS,Dicker DT, et al. Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines. Cell Cycle, 2007, 6(20): 2554-2562.
14
Dittmar T,Nagler C,Schwitalla S, et al. Recurrence cancer stem cells-made by cell fusion? Med Hypotheses, 2009, 73(4): 542-547.
15
Bindya J,Motomi O,Namiko Y, et al. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood, 2010, 115(8): 1610-1620.
16
Ikegami T. Transforming growth factor-beta signaling and liver cancer stem cell. Hepatol Res, 2009, 39(9): 847-849.
17
Tang Y,Kitisin K,Jogunoori W, et al. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci USA, 2008, 105(7): 2445-2450.
18
You H,Ding W,Rountree CB. Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology, 2010. [Epub ahead of print]
19
Shi GM,Xu Y,Fan J, et al. Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials. J Cancer Res Clin Oncol, 2008, 134(11): 1155-1163.
20
Zhang A,London R,Schulz FM, et al. Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. Hepatology, 2009, 50(4): 903A..
21
Yang X,Fan J,Yang XR, et al. High expression levels of putative hepatic stem/progenitor cells biomarkers related to tumor angiogenesis and poor prognosis of hepatocellular carcinoma. J Am Coll Surg, 2009, 209(3):S89.
22
Nie D. Cancer stem cell and niche. Front Biosci, 2010, 2: 184-193.
23
Kuhn NZ,Tuan RS. Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis. J Cell Physiol, 2010, 222(2): 268-277.
24
Liu JM,Mao BY,Hong S, et al. The postoperative brain tumour stem cell (BTSC) niche and cancer recurrence. Adv Ther, 2008, 25(5): 389-398.
25
Soderdahl G,Barkholt L,Hentschke P, et al. Liver transplantation followed by adjuvant nonmyeloablative hemopoietic stem cell transplantation for advanced primary liver cancer in humans. Transplantation, 2003, 75(7): 1061-1066.
26
Xu X,Xing B,Hu M, et al. Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy. Cytotherapy, 2009, ahead of print.
27
Chiba T,Miyagi S,Saraya A, et al. The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res, 2008, 68(19): 7742-7749.
[1] 卫杨文祥, 黄浩然, 刘予豪, 陈镇秋, 王海彬, 周驰. 股骨头坏死细胞治疗的前景和挑战[J]. 中华关节外科杂志(电子版), 2023, 17(05): 694-700.
[2] 韩李念, 王君. 放射性皮肤损伤治疗的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 533-537.
[3] 全勇, 冉新泽, 胡梦佳, 陈芳, 陈乃成, 廖伟年, 陈默, 申明强, 陈石磊, 王崧, 王军平. 低氧习服在小鼠造血干细胞急性放射损伤修复中的作用观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 293-298.
[4] 贾蔓箐, 卞婧, 周业平. 对小剂量胰岛素局部注射促进脂肪干细胞移植成活及改善糖尿病创面愈合临床观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 312-316.
[5] 贺林凤, 曹雨, 张宁, 冉新泽, 王锋超. 肠干细胞调控与肠道放射损伤修复的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 358-363.
[6] 高雷, 李芳, 巴雅力嘎, 李全, 巴特. 干细胞源性外泌体在创伤修复中免疫作用的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 364-367.
[7] 杨倩, 李翠芳, 张婉秋. 原发性肝癌自发性破裂出血急诊TACE术后的近远期预后及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 33-36.
[8] 孔欣, 宋宝全, 刘吟, 张剑, 仇惠英, 吴德沛. 异基因造血干细胞移植并发难治性呃逆一例[J]. 中华移植杂志(电子版), 2023, 17(04): 253-255.
[9] 唐英俊, 李华娟, 王赛妮, 徐旺, 刘峰, 李羲, 郝新宝, 黄华萍. 人脐带间充质干细胞治疗COPD小鼠及机制分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 476-480.
[10] 张文华, 陶焠, 胡添松. 不同部位外生型肝癌临床病理特点及其对术后肝内复发和预后影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 651-655.
[11] 张海涛, 贾哲, 马超, 张其坤, 武聚山, 郭庆良, 曾道炳, 栗光明, 王孟龙. 手术切除与射频消融治疗血管周围型单发小肝癌临床疗效分析[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 523-527.
[12] 李翠平, 陈晓燕, 钱师宇, 林惠珠, 曾彩辉, 阳莉, 卢建溪. 不同抗凝剂保存液对脐血培养的NK细胞增殖及杀伤效应的影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 572-576.
[13] 韩冰, 顾劲扬. 深度学习神经网络在肝癌诊疗中的研究及应用前景[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 480-485.
[14] 杨蕴钊, 周诚, 石美涵, 赵静, 白雪源. 人羊水间充质干细胞对膜性肾病大鼠的治疗作用[J]. 中华肾病研究电子杂志, 2023, 12(04): 181-186.
[15] 梁宇同, 丁旭, 马国慧, 黄艳红. 间充质干细胞在宫腔粘连治疗中的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(05): 596-599.
阅读次数
全文


摘要