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中华普通外科学文献(电子版) ›› 2014, Vol. 08 ›› Issue (02) : 143 -147. doi: 10.3877/cma.j.issn.1674-0793.2014.02.015

所属专题: 文献

综述

MicroRNA在乙型肝炎病毒相关肝细胞癌侵袭转移中的研究进展
陈国栋1, 余子建2, 黄宗海3,()   
  1. 1. 421001 衡阳,南华大学附属第一医院普通外科;南方医科大学附属珠江医院普通外科
    2. 421001 衡阳,南华大学附属第一医院普通外科
    3. 南方医科大学附属珠江医院普通外科
  • 收稿日期:2014-01-12 出版日期:2014-04-01
  • 通信作者: 黄宗海

Research progress of microRNA in invasion and metastasis of hepatitis B virus-related hepatocellular carcinoma

Guodong Chen1, Zijian Yu2, Zonghai Huang3,()   

  1. 1. Department of General Surgery, the First Affiliated Hospital of University of South China, Hengyang 421001, China
  • Received:2014-01-12 Published:2014-04-01
  • Corresponding author: Zonghai Huang
  • About author:
    Correponding author: Huang Zonghai, Email:
引用本文:

陈国栋, 余子建, 黄宗海. MicroRNA在乙型肝炎病毒相关肝细胞癌侵袭转移中的研究进展[J]. 中华普通外科学文献(电子版), 2014, 08(02): 143-147.

Guodong Chen, Zijian Yu, Zonghai Huang. Research progress of microRNA in invasion and metastasis of hepatitis B virus-related hepatocellular carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(02): 143-147.

MicroRNA(miRNA)是一种内源性非编码小分子单链RNA,其异常表达与包括肝细胞癌(HCC)在内的多种疾病密切相关。术后复发转移是HCC死亡的主要原因,而乙型肝炎病毒(HBV)感染是HCC发生发展最关键的危险因素。研究证实miRNA在HBV相关HCC中的异常表达与其侵袭转移密切相关,作为重要标志物对于HBV相关HCC预后判断及治疗具有较好的应用前景。

MicroRNA (miRNA) is a kind of single stranded small endogenous non-coding RNA. Growing evidence indicates that its abnormal expression may play an important role in many diseases, including hepatocellular carcinoma (HCC). Postoperative recurrence and metastasis are the main causes of death, and the infection of hepatitis B virus (HBV) is the most key risk factor for the development and progression of HCC. Numerous reports have demonstrated that the dysfunction of miRNA is associated with invasion and metastasis in HBV related HCC, which as a newer marker will have a bright prospect for prognosis and treatment for the disease.

1
Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma[J]. Nat Rev Cancer, 2013, 13(2): 123-135.
2
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2): 281-297.
3
Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact[J]. J Clin Oncol, 2009, 27(34): 5848-5856.
4
Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. J CA Cancer J Clin, 2011, 61(2): 69-90.
5
Chen JG, Zhang SW. Liver cancer epidemic in China: past, present and future[J]. Semin Cancer Biol, 2011, 21(1): 59-69.
6
Yao M, Yao DF, Bian YZ, et al. Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma[J]. Hepatobiliary Pancreat Dis Int, 2013, 12(2): 171-179.
7
Lin S, Hoffmann K, Schemmer P. Treatment of hepatocellular carcinoma: a systematic review[J]. Liver Cancer, 2012, 1(3-4): 144-158.
8
Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma[J]. Oncogene, 2010, 29(36): 4989-5005.
9
Jin WB, Wu FL, Kong D, et al. HBV-encoded microRNA candidate and its target[J]. Comput Biol Chem, 2007, 31(2): 124-126.
10
Sullivan CS, Grundhoff AT, Tevethia S, et al. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells[J]. Nature, 2005, 435(7042): 682-686.
11
Liu Y, Zhao JJ, Wang CM, et al. Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line[J]. Chin Med J(Engl), 2009, 122(1): 10-14.
12
Zhang GL, Li YX, Zheng SQ, et al. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210[J]. Antiviral Res, 2010, 88(2): 169-175.
13
Wu FL, Jin WB, Li JH, et al. Targets for human encoded microRNAs in HBV genes[J]. Virus Genes, 2011, 42(2): 157-161.
14
Qiu L, Fan H, Jin W, et al. miR-122-induced downregulation of HO-1 negatively affects miR-122-mediated suppression of HBV[J]. Biochem Biophys Res Commun, 2010, 398(4): 771-777.
15
Liu WH, Yeh SH, Chen PJ. Role of microRNAs in hepatitis B virus replication and pathogenesis[J]. Biochim Biophys Acta, 2011, 1809(11-12): 678-685.
16
Wolf K, Friedl P. Molecular mechanisms of cancer cell invasion and plasticity[J]. Br J Dermatol, 2006, 154 (Suppl 1): 11-15.
17
Hurst DR, Welch DR. Metastasis suppressor genes at the interface between the environment and tumor cell growth[J]. Int Rev Cell Mol Biol, 2011, 286: 107-180.
18
Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities[J]. Nat Rev Cancer, 2010, 10(1): 9-22.
19
Roycik MD, Fang X, Sang QX. A fresh prospect of extracellular matrix hydrolytic enzymes and their substrates[J]. Curr Pharm Des, 2009, 15(12): 1295-1308.
20
Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, et al. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis[J]. Int J Mol Sci, 2012, 13(2): 1347-1379.
21
Zender L, Villanueva A, Tovar V, et al. Cancer gene discovery in hepatocellular carcinoma[J]. J Hepatol, 2010, 52(6): 921-929.
22
Zhang ZZ, Liu X, Wang DQ, et al. Hepatitis B virus and hepatocellular carcinoma at the miRNA level[J]. World J Gastroenterol, 2011, 17(28): 3353-3358.
23
Wang W, Zhao LJ, Tan YX, et al. Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma[J]. World J Gastroenterol, 2012, 18(38): 5442-5453.
24
Li J, Shi W, Gao Y, et al. Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma[J]. Clin Lab, 2013, 59(9-10): 1009-1015.
25
Liu AM, Zhang C, Burchard J, et al. Global regulation on microRNA in hepatitis B virus-associated hepatocellular carcinoma[J]. OMICS, 2011, 15(3): 187-191.
26
Fan CG, Wang CM, Tian C, et al. miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3[J]. Oncol Rep, 2011, 26(5): 1281-1286.
27
Li C, Wang Y, Wang S, et al. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion[J]. J Virol, 2013, 87(4): 2193-2205.
28
Fu Y, Wei X, Tang C, et al. Circulating microRNA-101 as a potential biomarker for hepatitis B virus-related hepatocellular carcinoma[J]. Oncol Lett, 2013, 6(6): 1811-1815.
29
Zhu HT, Dong QZ, Sheng YY, et al. MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection[J]. PLoS One, 2012, 7(12): e52393.
30
Zhang X, Liu S, Hu T, et al. Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression[J]. Hepatology, 2009, 50(2): 490-499.
31
Huang J, Wang Y, Guo Y, et al. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1[J]. Hepatology, 2010, 52(1): 60-70.
32
Wang Y, Lu Y, Toh ST, et al. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3[J]. J Hepatol, 2010, 53(1): 57-66.
33
Wu G, Yu F, Xiao Z, et al. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro[J]. Br J Cancer, 2011, 105(1): 146-153.
34
Kong G, Zhang J, Zhang S, et al. Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model[J]. PLoS One, 2011, 6(5): e19518.
35
Wei X, Xiang T, Ren G, et al. miR-101 is down-regulated by the methyltransferase 3A[J]. Cell Signal, 2013, 25(2): 439-446.
36
Xu X, Fan Z, Kang L, et al. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis[J]. J Clin Invest, 2013, 123(2): 630-645.
37
Xu Y, Li L, Xiang X, et al. Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis[J]. Gene, 2013, 527(2): 584-593.
38
Song FJ, Chen KX. Single-nucleotide polymorphisms among microRNA: big effects on cancer[J]. Chin J Cancer, 2011, 30(6): 381-391.
39
Qi P, Dou TH, Geng L, et al. Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection[J]. Hum Immunol, 2010, 71(6): 621-626.
40
Kwak MS, Lee DH, Cho Y, et al. Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients[J]. PLoS One, 2012, 7(7): e41983.
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