切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2014, Vol. 08 ›› Issue (02) : 143 -147. doi: 10.3877/cma.j.issn.1674-0793.2014.02.015

所属专题: 文献

综述

MicroRNA在乙型肝炎病毒相关肝细胞癌侵袭转移中的研究进展
陈国栋1, 余子建2, 黄宗海3,()   
  1. 1. 421001 衡阳,南华大学附属第一医院普通外科;南方医科大学附属珠江医院普通外科
    2. 421001 衡阳,南华大学附属第一医院普通外科
    3. 南方医科大学附属珠江医院普通外科
  • 收稿日期:2014-01-12 出版日期:2014-04-01
  • 通信作者: 黄宗海

Research progress of microRNA in invasion and metastasis of hepatitis B virus-related hepatocellular carcinoma

Guodong Chen1, Zijian Yu2, Zonghai Huang3,()   

  1. 1. Department of General Surgery, the First Affiliated Hospital of University of South China, Hengyang 421001, China
  • Received:2014-01-12 Published:2014-04-01
  • Corresponding author: Zonghai Huang
  • About author:
    Correponding author: Huang Zonghai, Email:
引用本文:

陈国栋, 余子建, 黄宗海. MicroRNA在乙型肝炎病毒相关肝细胞癌侵袭转移中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2014, 08(02): 143-147.

Guodong Chen, Zijian Yu, Zonghai Huang. Research progress of microRNA in invasion and metastasis of hepatitis B virus-related hepatocellular carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(02): 143-147.

MicroRNA(miRNA)是一种内源性非编码小分子单链RNA,其异常表达与包括肝细胞癌(HCC)在内的多种疾病密切相关。术后复发转移是HCC死亡的主要原因,而乙型肝炎病毒(HBV)感染是HCC发生发展最关键的危险因素。研究证实miRNA在HBV相关HCC中的异常表达与其侵袭转移密切相关,作为重要标志物对于HBV相关HCC预后判断及治疗具有较好的应用前景。

MicroRNA (miRNA) is a kind of single stranded small endogenous non-coding RNA. Growing evidence indicates that its abnormal expression may play an important role in many diseases, including hepatocellular carcinoma (HCC). Postoperative recurrence and metastasis are the main causes of death, and the infection of hepatitis B virus (HBV) is the most key risk factor for the development and progression of HCC. Numerous reports have demonstrated that the dysfunction of miRNA is associated with invasion and metastasis in HBV related HCC, which as a newer marker will have a bright prospect for prognosis and treatment for the disease.

1
Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma[J]. Nat Rev Cancer, 2013, 13(2): 123-135.
2
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2): 281-297.
3
Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact[J]. J Clin Oncol, 2009, 27(34): 5848-5856.
4
Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. J CA Cancer J Clin, 2011, 61(2): 69-90.
5
Chen JG, Zhang SW. Liver cancer epidemic in China: past, present and future[J]. Semin Cancer Biol, 2011, 21(1): 59-69.
6
Yao M, Yao DF, Bian YZ, et al. Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma[J]. Hepatobiliary Pancreat Dis Int, 2013, 12(2): 171-179.
7
Lin S, Hoffmann K, Schemmer P. Treatment of hepatocellular carcinoma: a systematic review[J]. Liver Cancer, 2012, 1(3-4): 144-158.
8
Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma[J]. Oncogene, 2010, 29(36): 4989-5005.
9
Jin WB, Wu FL, Kong D, et al. HBV-encoded microRNA candidate and its target[J]. Comput Biol Chem, 2007, 31(2): 124-126.
10
Sullivan CS, Grundhoff AT, Tevethia S, et al. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells[J]. Nature, 2005, 435(7042): 682-686.
11
Liu Y, Zhao JJ, Wang CM, et al. Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line[J]. Chin Med J(Engl), 2009, 122(1): 10-14.
12
Zhang GL, Li YX, Zheng SQ, et al. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210[J]. Antiviral Res, 2010, 88(2): 169-175.
13
Wu FL, Jin WB, Li JH, et al. Targets for human encoded microRNAs in HBV genes[J]. Virus Genes, 2011, 42(2): 157-161.
14
Qiu L, Fan H, Jin W, et al. miR-122-induced downregulation of HO-1 negatively affects miR-122-mediated suppression of HBV[J]. Biochem Biophys Res Commun, 2010, 398(4): 771-777.
15
Liu WH, Yeh SH, Chen PJ. Role of microRNAs in hepatitis B virus replication and pathogenesis[J]. Biochim Biophys Acta, 2011, 1809(11-12): 678-685.
16
Wolf K, Friedl P. Molecular mechanisms of cancer cell invasion and plasticity[J]. Br J Dermatol, 2006, 154 (Suppl 1): 11-15.
17
Hurst DR, Welch DR. Metastasis suppressor genes at the interface between the environment and tumor cell growth[J]. Int Rev Cell Mol Biol, 2011, 286: 107-180.
18
Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities[J]. Nat Rev Cancer, 2010, 10(1): 9-22.
19
Roycik MD, Fang X, Sang QX. A fresh prospect of extracellular matrix hydrolytic enzymes and their substrates[J]. Curr Pharm Des, 2009, 15(12): 1295-1308.
20
Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, et al. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis[J]. Int J Mol Sci, 2012, 13(2): 1347-1379.
21
Zender L, Villanueva A, Tovar V, et al. Cancer gene discovery in hepatocellular carcinoma[J]. J Hepatol, 2010, 52(6): 921-929.
22
Zhang ZZ, Liu X, Wang DQ, et al. Hepatitis B virus and hepatocellular carcinoma at the miRNA level[J]. World J Gastroenterol, 2011, 17(28): 3353-3358.
23
Wang W, Zhao LJ, Tan YX, et al. Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma[J]. World J Gastroenterol, 2012, 18(38): 5442-5453.
24
Li J, Shi W, Gao Y, et al. Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma[J]. Clin Lab, 2013, 59(9-10): 1009-1015.
25
Liu AM, Zhang C, Burchard J, et al. Global regulation on microRNA in hepatitis B virus-associated hepatocellular carcinoma[J]. OMICS, 2011, 15(3): 187-191.
26
Fan CG, Wang CM, Tian C, et al. miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3[J]. Oncol Rep, 2011, 26(5): 1281-1286.
27
Li C, Wang Y, Wang S, et al. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion[J]. J Virol, 2013, 87(4): 2193-2205.
28
Fu Y, Wei X, Tang C, et al. Circulating microRNA-101 as a potential biomarker for hepatitis B virus-related hepatocellular carcinoma[J]. Oncol Lett, 2013, 6(6): 1811-1815.
29
Zhu HT, Dong QZ, Sheng YY, et al. MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection[J]. PLoS One, 2012, 7(12): e52393.
30
Zhang X, Liu S, Hu T, et al. Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression[J]. Hepatology, 2009, 50(2): 490-499.
31
Huang J, Wang Y, Guo Y, et al. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1[J]. Hepatology, 2010, 52(1): 60-70.
32
Wang Y, Lu Y, Toh ST, et al. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3[J]. J Hepatol, 2010, 53(1): 57-66.
33
Wu G, Yu F, Xiao Z, et al. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro[J]. Br J Cancer, 2011, 105(1): 146-153.
34
Kong G, Zhang J, Zhang S, et al. Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model[J]. PLoS One, 2011, 6(5): e19518.
35
Wei X, Xiang T, Ren G, et al. miR-101 is down-regulated by the methyltransferase 3A[J]. Cell Signal, 2013, 25(2): 439-446.
36
Xu X, Fan Z, Kang L, et al. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis[J]. J Clin Invest, 2013, 123(2): 630-645.
37
Xu Y, Li L, Xiang X, et al. Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis[J]. Gene, 2013, 527(2): 584-593.
38
Song FJ, Chen KX. Single-nucleotide polymorphisms among microRNA: big effects on cancer[J]. Chin J Cancer, 2011, 30(6): 381-391.
39
Qi P, Dou TH, Geng L, et al. Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection[J]. Hum Immunol, 2010, 71(6): 621-626.
40
Kwak MS, Lee DH, Cho Y, et al. Association of polymorphism in pri-microRNAs-371-372-373 with the occurrence of hepatocellular carcinoma in hepatitis B virus infected patients[J]. PLoS One, 2012, 7(7): e41983.
[1] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[2] 马旦杰, 黄品同, 徐琛, 周芳芳, 潘敏强. 超声造影LI-RADS系统联合甲胎蛋白对有无高危因素背景人群肝细胞癌的诊断价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(03): 288-296.
[3] 李敏, 杨世英, 高晓琴, 周丹, 唐筱, 张立婷. 维生素A与慢性肝病相关性研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(02): 65-70.
[4] 胡森焱, 徐冬, 方健, 谢冬冬, 王财庆. ICG荧光显影Laennec膜入路腹腔镜解剖性肝切除的临床研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 513-516.
[5] 陈政, 叶庆旺, 赵东波, 石鑫, 吴建强, 余德才. 定位针引导下腹腔镜精准局部肝切除应用探索[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(02): 125-128.
[6] 刘敏思, 李荣, 李媚. 基于GGT与Plt比值的模型在HBV相关肝细胞癌诊断中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 831-835.
[7] 张蔚林, 王哲学, 白峻阁, 黄忠诚, 肖志刚. 利用TCGA数据库构建基于miRNA的结直肠癌列线图预后模型[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 381-388.
[8] 李京, 牛博, 刘晓蓓, 魏新雪, 黄荣. circ-SESN2 沉默靶向调控miRNA-23a-5p/ULK1 在神经细胞氧化应激损伤中的作用机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 263-272.
[9] 董佳, 王坤, 张莉. 预后营养指数结合免疫球蛋白、血糖及甲胎蛋白对HBV 相关慢加急性肝衰竭患者治疗后预后不良的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 555-559.
[10] 胡静, 杨秀锦, 侯志云. HBV感染患者外周血ISGs表达水平变化及其与干扰素治疗疗效的关系[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 343-347.
[11] 莫鹏, 郭杏春, 梁秀娟, 王耀明. 超声引导与CT引导射频消融治疗肝细胞癌患者疗效及预后比较[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(02): 151-154.
[12] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[13] 陆知非, 华永飞, 姜哲康, 高过, 江寅, 王高卿. 初始不可切除肝癌转化治疗的影响因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(03): 268-274.
[14] 倪管崟, 缪小赟, 丁家安, 田鹏程, 倪才方. 锥形束计算机断层扫描在肝癌介入诊疗中的应用进展[J/OL]. 中华介入放射学电子杂志, 2024, 12(03): 256-260.
[15] 刘春林, 刘畅, 赵东岩, 李端萍, 刘建梅, 罗秋林. 利用室内质控与能力验证数据评定HBV DNA和HCV RNA测量不确定度[J/OL]. 中华临床实验室管理电子杂志, 2024, 12(02): 91-96.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?