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中华普通外科学文献(电子版) ›› 2014, Vol. 08 ›› Issue (04) : 280 -282. doi: 10.3877/cma.j.issn.1674-0793.2014.04.006

所属专题: 文献

论著

腹壁隆突性皮肤纤维肉瘤诊治策略及复发相关因素分析
刘祥厦1, 唐庆1, 许澍洽1, 黄洁新2, 许扬滨1,()   
  1. 1. 510080 广州,中山大学附属第一医院整形外科
    2. 广东省中医院影像科
  • 收稿日期:2013-01-14 出版日期:2014-08-01
  • 通信作者: 许扬滨

Dermatofibrosarcoma protuberans of the abdominal wall: the diagnosis, treatment strategy and prognosis

Xiangxia Liu1, Qing Tang1, Shuqia Xu1, Jiexin Huang2, Yangbin Xu1,()   

  1. 1. Division of Plastic and Reconstructive Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
  • Received:2013-01-14 Published:2014-08-01
  • Corresponding author: Yangbin Xu
  • About author:
    Corresponding author: Xu Yangbin, Email:
引用本文:

刘祥厦, 唐庆, 许澍洽, 黄洁新, 许扬滨. 腹壁隆突性皮肤纤维肉瘤诊治策略及复发相关因素分析[J/OL]. 中华普通外科学文献(电子版), 2014, 08(04): 280-282.

Xiangxia Liu, Qing Tang, Shuqia Xu, Jiexin Huang, Yangbin Xu. Dermatofibrosarcoma protuberans of the abdominal wall: the diagnosis, treatment strategy and prognosis[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(04): 280-282.

目的

探讨腹壁隆突性纤维肉瘤的诊断与治疗方法,分析复发相关因素。

方法

对51例腹壁隆突性皮肤纤维肉瘤患者的临床资料进行回顾性分析,根据是否放疗、切缘距离及肿瘤大小进行分组,比较组间术后复发率的差异。

结果

患者肿物切除术后创面缺损面积4 cm×6cm至20cm×26cm,均I期予植皮、局部皮瓣或游离皮瓣修复,术后随访1~30.4年,总体复发率为23.1%,1例复发7次的患者发生肺转移。非放疗组与放疗组的复发率差异无统计学意义;切缘≤2cm组的复发率明显高于切缘>2cm组(37.5% vs 19.4%,χ2=12.49,P﹤0.01);肿瘤≤5cm组患者复发率为16.7%,肿瘤>5cm组患者的复发率为25.9%,两组间差异有显著统计学意义(χ2=3.91,P﹤0.05)。

结论

腹壁隆突性纤维肉瘤单纯局部切除复发率高,手术需行广泛切除,结合术后放疗并不能降低局部复发率。复发可能与肿瘤的大小、切缘距离等因素有关;多次复发可引起远处转移。

Objective

To investigate the diagnosis and treatment of dermatofibrosarcoma protuberans(DFSP) in abdominal wall and to analyze the correlative factors of recurrence.

Methods

Fifty-one cases of DFSP in abdominal wall were collected, the treatment and the correlative factors of recurrence subgrouping by the cutting edge and tumor size were analyzed retrospectively.

Results

The defect area was between 4 cm×6 cm to 20 cm×26 cm and patients received stage I repair. The total recurrent rate was 23.1% (9/39) with a regular follow up of 1-30.4 years, and there was one case with lung metastasis after 7 times of recurrence. The recurrence rate in non-radiotherapy group and radiotherapy group was 22.7% (5/22) and 23.5% (4/17) respectively, which showed no statistically significant difference. Comparing to 19.4% (6/31) in the group whose cutting edge was more than 2 cm from the tumor, the recurrence rate in the group less than 2 cm was 37.5%(3/8). There was significant difference between these two groups (χ2=12.49, P﹤0.01). Less recurrence was observed in group with tumor size less than 5 cm(2/12), comparing to the group with tumor size larger than 5 cm (7/27)(χ2=3.91, P﹤0.05).

Conclusions

DFSP in abdominal wall which tends to recur easily needs radically surgical intervention and repairs with skin-grafting or/and flaps. Radiotherapy after surgical resection may not contribute to better prognosis. Local recurrence is correlated to tumor size or/and cutting edge. Repeated recurrence may cause distant metastasis.

[1]
Cai H,Wang Y,Wu J, et al. Dermatofibrosarcoma protuberans: clinical diagnoses and treatment results of 260 cases in China[J]. J Surg Oncol, 2012, 105(2): 142-148.
[2]
Kim M,Huh CH,Cho KH, et al. A study on the prognostic value of clinical and surgical features of dermatofibrosarcoma protuberans in Korean patients[J]. J Eur Acad Dermatol Venereol, 2012, 26(8): 964-971.
[3]
Iqbal CW,St Peter S,Ishitani MB. Pediatric dermatofibrosarcoma protuberans: multi-institutional outcomes[J]. J Surg Res, 2011, 170(1): 69-72.
[4]
Kurlander DE,Martires KJ,Chen Y, et al. Risk of subsequent primary malignancies after dermatofibrosarcoma protuberans diagnosis: A national study[J]. J Am Acad Dermatol, 2013, 68(5): 790-796.
[5]
Wunder JS,Nielsen TO,Maki RG, et al. Opportunities for improving the therapeutic ratio for patients with sarcoma[J]. Lancet Oncol, 2007, 8(6): 513-524.
[6]
郑明章,陈志坚,林志雄, 等. 放射治疗在隆突性皮肤纤维肉瘤中的地位[J]. 中华放射肿瘤学杂志, 2000, 9(4): 241-242.
[7]
Huber GF,Matthews TW,Dort JC. Radiation-induced soft tissue sarcomas of the head and neck[J]. J Otolaryngol, 2007, 36(2): 93-97.
[8]
Maki RG,Awan RA,Dixon RH, et al. Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans[J]. Int J Cancer, 2002, 100(6): 623-626.
[9]
Johnson-Jahangir H,Ratner D. Advances in management of dermatofibrosarcoma protuberans[J]. Dermatol Clin, 2011, 29(2): 191-200.
[10]
Malhotra B,Schuetze SM. Dermatofibrosarcoma protruberans treatment with platelet-derived growth factor receptor inhibitor: a review of clinical trial results[J]. Curr Opin Oncol, 2012, 24(4): 419-24.
[11]
王春萌,罗志国,陈勇, 等. 伊马替尼治疗隆突性皮肤纤维肉瘤肺转移附2例报道[J]. 中国癌症杂志, 2012, 22(9): 711-713.
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