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中华普通外科学文献(电子版) ›› 2019, Vol. 13 ›› Issue (01) : 58 -62. doi: 10.3877/cma.j.issn.1674-0793.2019.01.013

所属专题: 文献

综述

雌激素受体β水平预测乳腺癌预后的研究进展
曾益为1, 刘仁斌1,()   
  1. 1. 510630 广州,中山大学附属第三医院甲状腺乳腺外科
  • 收稿日期:2018-06-27 出版日期:2019-02-01
  • 通信作者: 刘仁斌
  • 基金资助:
    国家自然科学基金资助项目(81372815)

Research progress in the prediction of breast cancer prognosis by estrogen receptor beta

Yiwei Zeng1, Renbin Liu1,()   

  1. 1. Department of Breast and Thyroid Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2018-06-27 Published:2019-02-01
  • Corresponding author: Renbin Liu
  • About author:
    Corresponding author: Liu Renbin, Email:
引用本文:

曾益为, 刘仁斌. 雌激素受体β水平预测乳腺癌预后的研究进展[J]. 中华普通外科学文献(电子版), 2019, 13(01): 58-62.

Yiwei Zeng, Renbin Liu. Research progress in the prediction of breast cancer prognosis by estrogen receptor beta[J]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(01): 58-62.

乳腺癌是一种激素依赖性肿瘤,雌激素在其发生、发展中起重要作用,而雌激素须通过雌激素受体(ER)介导发挥生物学作用。ER是由其基因编码的一种核转录因子,包括α和β两个亚型。相关研究表明ERα表达缺失或突变与乳腺癌预后不良有关,而ERβ表达与乳腺癌预后的相关性,体外实验与临床研究的结果不尽相同。本文就ERβ及其亚型在乳腺癌发生、发展和内分泌治疗中的作用以及对乳腺癌预后的预测价值做一综述。

Breast cancer is a hormone-dependent tumor and estrogen plays an important role in its occurrence and development, while estrogen mediates through estrogen receptor (ER). ER is a nuclear transcriptional factor encoded by its genes, which includes two subtypes. Studies have shown that the absence or mutation of ERα expression is associated with poor prognosis of breast cancer, while the correlation between ERβ expression and breast cancer prognosis is different in vitro experiments and clinical studies. This article reviews the role of ERβ encapsulation, its subtype in the occurrence and development of breast cancer, its role in endocrine therapy and predictive value for breast cancer prognosis.

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