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中华普通外科学文献(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 249 -252. doi: 10.3877/cma.j.issn.1674-0793.2019.03.018

所属专题: 文献

综述

eRF3a/GSPT1在常见肿瘤发生发展过程中的作用
习一清1, 杨丽洁1, 王丹雯1, 杨张朔1, 冯茂辉1,(), 谢伟1   
  1. 1. 430071 武汉大学中南医院肿瘤外科
  • 收稿日期:2019-01-21 出版日期:2019-06-01
  • 通信作者: 冯茂辉
  • 基金资助:
    国家自然基金资助项目(81770283)

Mechanism of eRF3a/GSPT1 in tumor initiation and progression

Yiqing Xi1, Lijie Yang1, Danwen Wang1, Zhangshuo Yang1, Maohui Feng1,(), Wei Xie1   

  1. 1. Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  • Received:2019-01-21 Published:2019-06-01
  • Corresponding author: Maohui Feng
  • About author:
    Corresponding author: Feng Maohui, Email:
引用本文:

习一清, 杨丽洁, 王丹雯, 杨张朔, 冯茂辉, 谢伟. eRF3a/GSPT1在常见肿瘤发生发展过程中的作用[J/OL]. 中华普通外科学文献(电子版), 2019, 13(03): 249-252.

Yiqing Xi, Lijie Yang, Danwen Wang, Zhangshuo Yang, Maohui Feng, Wei Xie. Mechanism of eRF3a/GSPT1 in tumor initiation and progression[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(03): 249-252.

真核肽链释放因子3(eRF3a)作为真核肽链释放因子中的一员,在多种生物学过程中起着重要作用,它由调节细胞周期G1到S期的转换1基因(GSPT1)编码。近年来的证据表明,eRF3a及其编码基因GSPT1的表达与多种常见肿瘤的发展密切相关。本文就eRF3a/GSPT1在这些常见恶性肿瘤发生发展过程中所起的作用作一综述。

As a member of the eukaryotic peptide chain release factor family, eRF3a plays an important role in a variety of biological processes. It is encoded by the G1 to S phase transition 1 gene (GSPT1). In recent years, increasing evidence has indicated that eRF3a/GSPT1 is related to initiation and development of the common tumors. This paper is dedicated to depicting the roles of eRF3a/GSPT1 in the tumor development.

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