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中华普通外科学文献(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 425 -428. doi: 10.3877/cma.j.issn.1674-0793.2020.06.006

所属专题: 文献

论著

长链非编码RNA-CECR7在胃癌中的表达及预后价值
彭敏1, 任雁1, 严凤1, 伍映鑫,2   
  1. 1. 610500 成都医学院第一附属医院胃肠外科
    2. 610031 成都,西南交通大学附属医院 成都市第三人民医院胃肠外科
  • 收稿日期:2019-08-23 出版日期:2020-12-01
  • 通信作者: 伍映鑫

Expression of long-chain non-coding RNA-CECR7 and prognosis in gastric cancer

Min Peng1, Yan Ren1, Feng Yan1, Yingxin Wu,2   

  1. 1. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China
    2. Department of Gastrointestinal Surgery, Affiliated Hospital of Southwest Jiaotong University, the Third People’s Hospital of Chengdu, Chengdu 610031, China
  • Received:2019-08-23 Published:2020-12-01
  • Corresponding author: Yingxin Wu
  • About author:
    Corresponding author: Wu Yingxin, Email:
引用本文:

彭敏, 任雁, 严凤, 伍映鑫. 长链非编码RNA-CECR7在胃癌中的表达及预后价值[J/OL]. 中华普通外科学文献(电子版), 2020, 14(06): 425-428.

Min Peng, Yan Ren, Feng Yan, Yingxin Wu. Expression of long-chain non-coding RNA-CECR7 and prognosis in gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2020, 14(06): 425-428.

目的

探究长链非编码RNA(lncRNA)-CECR7在胃癌不同组织中的表达情况及其预后价值。

方法

以2015年5月至2016年5月成都医学院第一附属医院收治的78例胃癌患者为研究对象,采用实时荧光定量PCR(RT-PCR)方法检测胃癌组织、癌旁组织中lncRNA-CECR7相对表达情况。分析lncRNA-CECR7表达与患者临床病理特征的关系,绘制Kaplan-Meier曲线进行生存分析,Cox回归分析影响患者3年生存率的因素。

结果

胃癌组织中的lncRNA-CECR7相对表达量为1.87±0.25,显著高于癌旁组织的1.05±0.13,差异有统计学意义(t=25.701,P<0.001)。lncRNA-CECR7表达与肿瘤大小、Borrmann分型、TNM分期、分化类型、淋巴结转移有关(P<0.05)。患者3年生存率为62.82%(49/78),lncRNA-CECR7低表达组生存率显著高于高表达组(77.14% vs 51.16%,χ2=5.576,P=0.018)。肿瘤大小、TNM分期、淋巴结转移、lncRNA-CECR7表达水平是影响胃癌患者预后的独立因素(P<0.05)。

结论

lncRNA-CECR7在胃癌组织中的高表达与肿瘤大小、Borrmann分型、TNM分期有关,是影响胃癌患者3年生存的危险因素。

Objective

To investigate the expression of long non-coding RNA-CECR7 (lncRNA-CECR7) in gastric cancer and its relationship with prognosis.

Methods

Seventy-eight patients with gastric cancer admitted to the First Affiliated Hospital of Chengdu Medical College from May 2015 to May 2016 were studied. The relative expression of lncRNA-CECR7 in gastric cancer tissues and adjacent tissues was detected by quantitative real-time PCR (RT-PCR). The relationship between the expression of lncRNA-CECR7 and the clinicopathological parameters of patients were analyzed. Kaplan-Meier curve survival analysis and Cox regression analysis were used to analyze the factors affecting the 3-year survival rate.

Results

The expression level of lncRNA-CECR7 in gastric cancer tissues was higher than that in adjacent tissues (1.87±0.25 vs 1.05±0.13, t=25.701, P<0.001). The expression of lncRNA-CECR7 was correlated with tumor size, Borrmann typing, TNM stage, differentiation type and lymph node metastasis (P<0.05). The 3-year survival rate was 62.82%. Tumor size, TNM stage, lymph node metastasis and expression of lncRNA-CECR7 were independent factors affecting the prognosis of gastric cancer patients (P<0.05). The survival rate of low expression group of lncRNA-CECR7 was significantly higher than that of high expression group of lncRNA-CECR7 (77.14% vs 51.16%, χ2=5.576, P=0.018).

Conclusion

lncRNA-CECR7 is highly expressed in gastric cancer tissues, which is related to tumor size, Borrmann typing and TNM stage, and is a risk factor for 3-year survival of gastric patients.

表1 lncRNA-CECR7表达与78例胃癌患者临床病理特征的关系(例)
图1 lncRNA-CECR7低表达和高表达的胃癌患者生存曲线分析
表2 影响胃癌患者3年生存状态的临床单因素分析(例)
表3 78例胃癌患者预后影响因素的Cox回归分析
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