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中华普通外科学文献(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 467 -470. doi: 10.3877/cma.j.issn.1674-0793.2020.06.018

所属专题: 文献

综述

促甲状腺激素受体与甲状腺乳头状癌的关系研究进展
杨传鑫1, 笪东祝1, 张琨茹1, 刘俊1,()   
  1. 1. 201620 上海交通大学附属第一人民医院乳腺甲状腺血管外科
  • 收稿日期:2020-03-06 出版日期:2020-12-01
  • 通信作者: 刘俊
  • 基金资助:
    上海市松江区科技攻关项目(19SJKJGG17)

Advances in the relationship between thyroid stimulating hormone receptor and papillary thyroid carcinoma

Chuanxin Yang1, Dongzhu Da1, Kunru Zhang1, Jun Liu1,()   

  1. 1. Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai 201620, China
  • Received:2020-03-06 Published:2020-12-01
  • Corresponding author: Jun Liu
  • About author:
    Corresponding author: Liu Jun, Email:
引用本文:

杨传鑫, 笪东祝, 张琨茹, 刘俊. 促甲状腺激素受体与甲状腺乳头状癌的关系研究进展[J/OL]. 中华普通外科学文献(电子版), 2020, 14(06): 467-470.

Chuanxin Yang, Dongzhu Da, Kunru Zhang, Jun Liu. Advances in the relationship between thyroid stimulating hormone receptor and papillary thyroid carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2020, 14(06): 467-470.

甲状腺乳头状癌(PTC)是最常见的甲状腺癌,研究发现,PTC的发生、发展与促甲状腺激素受体(TSHR)有着密切关联。TSHR突变在PTC中并不少见,且与PTC淋巴结转移相关,还可诱发PTC。PTC存在高TSHR启动子甲基化风险,这可能有助于PTC的病理诊断与分期。PTC的外周血TSHR转录水平在术前和复发转移时明显上升,在术后显著下降,其有助于PTC的术前诊断和术后随访,还与PTC淋巴结转移相关。TSHR蛋白在PTC中有异常的表达水平及分布,可能与PTC的远处转移有关。此外,其他基因如BRAF V600E突变、lncRNA-PVT1、miRNA-106a等,对PTC中TSHR的表达可能具有调节作用。

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. It has been found that the development of PTC is closely related to thyroid stimulating hormone receptor (TSHR). TSHR mutation is not uncommon in PTC, which is related to lymph node metastasis, and it can also induce PTC. PTC has a high risk of TSHR promoter methylation, which may contribute to the pathological diagnosis and stage of PTC. The level of TSHR transcription in peripheral blood of PTC increases significantly before operation, recurrence and metastasis, while it decreases significantly after operation, which is helpful for preoperative diagnosis and postoperative follow-up of PTC, and it also related to PTC lymph node metastasis. TSHR protein has abnormal expression level and distribution in PTC, which may also be related to the distant metastasis of PTC. In addition, other genes such as BRAF V600E mutation, lncRNA-PVT1 and miRNA-106a may regulate the expression of TSHR in PTC.

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