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中华普通外科学文献(电子版) ›› 2021, Vol. 15 ›› Issue (01) : 66 -69. doi: 10.3877/cma.j.issn.1674-0793.2021.01.017

所属专题: 文献

综述

血小板在肝细胞癌发生和转移中的研究进展
刘双池1, 庞青1, 谈燚1,()   
  1. 1. 233000 蚌埠医学院第一附属医院肝胆外科
  • 收稿日期:2020-09-02 出版日期:2021-02-01
  • 通信作者: 谈燚
  • 基金资助:
    安徽省自然科学基金杰出青年项目(2008085J37); 安徽高校自然科学研究重大项目(KJ2018ZD022); 国家自然科学基金资助项目(81600452); 蚌埠医学院研究生科研创新计划资助立项项目(Byycx20085)

Research progress of platelet in the carcinogenesis and metastasis of hepatocellular carcinoma

Shuangchi Liu1, Qing Pang1, Yi Tan1,()   

  1. 1. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Received:2020-09-02 Published:2021-02-01
  • Corresponding author: Yi Tan
引用本文:

刘双池, 庞青, 谈燚. 血小板在肝细胞癌发生和转移中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2021, 15(01): 66-69.

Shuangchi Liu, Qing Pang, Yi Tan. Research progress of platelet in the carcinogenesis and metastasis of hepatocellular carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(01): 66-69.

肝细胞癌(HCC)是临床上最常见的原发性肝癌,其发生、发展通常与慢性炎症和肝损害有关。血小板不仅是肝损伤后再生的基础,而且在促进HCC发生和转移中所起的作用也得到较多关注。血小板既能在HCC肿瘤微环境中直接诱导肿瘤细胞生长和帮助肿瘤细胞躲避免疫杀伤,又能通过分泌的特异性生长因子和血管生成因子诱导肿瘤滋养血管生成促进HCC进展。此外,血小板相关衍生物也对HCC肿瘤细胞的增殖和转移存在重要影响。详细了解血小板在HCC中的作用,对于优化HCC肿瘤治疗方案和探索新的治疗策略很有必要。本综述详细报道血小板在HCC发生和转移中作用的相关机制及最新研究进展。

Hepatocellular carcinoma (HCC) is the most common primary liver cancer in clinic. The occurrence and development of HCC is usually related to chronic inflammation and liver damage. Platelets play a key role in the regeneration after liver injury. In recent years, more and more attentions have been paid to the role of platelets in promoting the occurrence and metastasis of HCC. Several specific growth factors and angiogenic factors secreted by platelets promote the progression of HCC by inducing tumor nourishing angiogenesis. In addition, platelet related derivatives can directly affect the proliferation and metastasis of HCC tumor cells. A detailed understanding of the role of platelets in HCC is necessary to optimize the treatment of tumors and explore new treatment strategies. This review will report the potential mechanisms and recent progress of the role of platelets in occurrence and metastasis of HCC in detail.

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