切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 141 -145. doi: 10.3877/cma.j.issn.1674-0793.2022.02.012

综述

肝细胞癌肺转移的治疗现状
卢潼辉1, 徐锋1,()   
  1. 1. 110004 沈阳,中国医科大学附属盛京医院普通外科
  • 收稿日期:2022-02-19 出版日期:2022-04-01
  • 通信作者: 徐锋
  • 基金资助:
    辽宁省自然科学基金项目(20180551193,2020-MS-181); 盛京医院345人才工程计划资助项目(40B)

Current status of the treatment of hepatocellular carcinoma with pulmonary metastasis

Tonghui Lu1, Feng Xu1,()   

  1. 1. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2022-02-19 Published:2022-04-01
  • Corresponding author: Feng Xu
引用本文:

卢潼辉, 徐锋. 肝细胞癌肺转移的治疗现状[J/OL]. 中华普通外科学文献(电子版), 2022, 16(02): 141-145.

Tonghui Lu, Feng Xu. Current status of the treatment of hepatocellular carcinoma with pulmonary metastasis[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2022, 16(02): 141-145.

肝细胞癌(简称"肝癌")是我国第2位肿瘤致死病因,肝外转移是其预后不良的重要原因。随着影像学技术的不断进步,肝癌合并肝外转移的发现率逐年上升,其中肺是最常见的肝外转移器官。肝癌肺转移患者情况复杂,处理起来十分棘手,治疗方式尚无定论,各类指南仅建议行系统治疗,但收效甚微。本文归纳总结了肝癌肺转移的各种治疗手段和研究现状,以期为患者提供最佳个体化的综合治疗策略,从而提高其生存获益。

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death in China, and extrahepatic metastasis is an important reason for its poor prognosis. With the continuous progress of imaging technology, the detection rate of HCC with extrahepatic metastasis is increasing year by year, among which the lung is the most common extrahepatic metastatic organ. The situation of HCC patients with lung metastasis is complex, which is very difficult to deal with and the treatment mode is still inconclusive. All kinds of guidelines only recommend systematic treatment, but with little effect. In this paper, various treatments for lung metastasis of HCC are summarized in order to provide the best individualized comprehensive treatment strategy for patients, so as to improve their survival benefits.

[1]
Zheng R, Zhang S, Zeng H, et al. Cancer incidence and mortality in China, 2016[J]. JNCC, 2022, 2(1): 1-9.
[2]
Wu W, He X, Andayani D, et al. Pattern of distant extrahepatic metastases in primary liver cancer: A SEER based study[J]. J Cancer, 2017, 8(12): 2312-2318.
[3]
Wu C, Ren X, Zhang Q. Incidence, risk factors, and prognosis in patients with primary hepatocellular carcinoma and lung metastasis: A population-based study[J]. Cancer Manag Res, 2019, 11: 2759-2768.
[4]
Hu Z, Li W, Huang P, et al. Therapeutic significance and indications of pulmonary metastasectomy for hepatocellular carcinoma following liver resection[J]. Int J Surg, 2017, 48: 23-31.
[5]
Lee HP, Yun JK, Jung HS, et al. Surgical outcomes of pulmonary metastasectomy in hepatocellular carcinoma patients according to approach method: thoracoscopic versus open approach[J]. World J Surg Oncol, 2021, 19(1): 33.
[6]
Mizuguchi S, Nishiyama N, Izumi N, et al. Clinical significance of multiple pulmonary metastasectomy for hepatocellular carcinoma[J]. World J Surg, 2016, 40(2): 380-387.
[7]
Kuo TM, Chang KM, Cheng TI, et al. Clinical factors predicting better survival outcome for pulmonary metastasectomy of hepatocellular carcinoma[J]. Liver Cancer, 2017, 6(4): 297-306.
[8]
叶欣,范卫君,王徽, 等. 热消融治疗原发性和转移性肺部肿瘤专家共识(2017年版)[J]. 中国肺癌杂志, 2017, 20(7): 433-445.
[9]
葛夕洪,刘祥,蔡金贞, 等. 肝癌肝移植术后肺寡转移瘤的微波消融治疗效果分析[J/CD]. 实用器官移植电子杂志, 2020, 8(5): 349-352.
[10]
Yuan Z, Liu B, Hu C, et al. Clinical outcomes of percutaneous thermal ablation for pulmonary metastases from hepatocellular carcinoma: A retrospective study[J]. Int J Hyperthermia, 2020, 37(1): 651-659.
[11]
Zuo T, Lin W, Liu F, et al. Artificial pneumothorax improves radiofrequency ablation of pulmonary metastases of hepatocellular carcinoma close to mediastinum[J]. BMC Cancer, 2021, 21(1): 505.
[12]
Hori A, Ohira R, Nakamura T, et al. Transarterial chemoembolization for pulmonary or mediastinal metastases from hepatocellular carcinoma[J]. Br J Radiol, 2020, 93(1110): 20190407.
[13]
李科,孔轶. 进口碘化油TACE联合洛铂治疗晚期肝癌肺转移的临床疗效观察[J]. 实用癌症杂志, 2018, 33(2): 244-246.
[14]
Wang Z, Kong QT, Li J, et al. Clinical outcomes of cyberknife stereotactic radiosurgery for lung metastases[J]. J Thorac Dis, 2015, 7(3): 407-412.
[15]
Zhang F, Wang J, Guo J, et al. Chinese Expert Consensus Workshop Report: Guideline for permanent iodine-125 seed implantation of primary and metastatic lung tumors[J]. Thorac Cancer, 2019, 10(2): 388-394.
[16]
Zhang L, Chen LH, Wang J, et al. CT-guided radioactive 125I seed implantation treatment of multiple pulmonary metastases of hepatocellular carcinoma[J]. Clin Radiol, 2014, 69(6): 624-629.
[17]
Soliman H, Ringash J, Jiang H, et al. Phase Ⅱ trial of palliative radiotherapy for hepatocellular carcinoma and liver metastases[J]. J Clin Oncol, 2013, 31(31): 3980-3986.
[18]
Pelizzaro F, Sammarco A, Dadduzio V, et al. Capecitabine in advanced hepatocellular carcinoma: A multicenter experience[J]. Dig Liver Dis, 2019, 51(12): 1713-1719.
[19]
Qin S, Bai Y, Lim HY, et al. Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia[J]. J Clin Oncol, 2013, 31(28): 3501-3508.
[20]
Hasegawa H, Kawakubo E, Kitagawa D, et al. Combined modality therapy for giant hepatocellular carcinoma and multiple lung metastases-a case study[J]. Gan To Kagaku Ryoho, 2020, 47(13): 2251-2253.
[21]
Shi J, Sun J, Liu C, et al. All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial[J]. Trials, 2019, 20(1): 245.
[22]
Mao X, Tey SK, Yeung C, et al. Nidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary fibroblasts to secrete tumor necrosis factor receptor 1[J]. Adv Sci(Weinh), 2020, 7(21): 2002157.
[23]
Yoshida M, Yamashita T, Okada H, et al. Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90[J]. Sci Rep, 2017, 7(1): 11292.
[24]
冯跃,郑家平,邵国良. 索拉非尼治疗肝细胞癌肺转移39例预后分析[J]. 肿瘤学杂志, 2018, 24(10): 987-991.
[25]
Yang T, Lu JH, Lin C, et al. Concomitant lung metastasis in patients with advanced hepatocellular carcinoma[J]. World J Gastroenterol, 2012, 18(20): 2533-2539.
[26]
Chen J, Lu S, Zhang Y, et al. Sorafenib monotherapy versus sorafenib combined with regional therapies for hepatocellular carcinoma patients with pulmonary oligometastases: A propensity score-matched analysis[J]. J Cancer, 2018, 9(10): 1745-1753.
[27]
Li ZJ, Dai HQ, Huang XW, et al. Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma[J]. Acta Pharmacol Sin, 2021, 42(2): 301-310.
[28]
Kudo M, Finn RS, Qin S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial[J]. Lancet, 2018, 391(10126): 1163-1173.
[29]
Lee MJ, Chang SW, Kim JH, et al. Real-world systemic sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: A multicenter retrospective study in Korea[J]. Invest New Drugs, 2021, 39(1): 260-268.
[30]
Du X, Chen D, Lin Z, et al. Efficacy of apatinib in advanced hepatocellular carcinoma with lung metastasis: A retrospective, multicenter study[J]. J BUON, 2019, 24(5): 1956-1963.
[31]
Zhu AX, Kang YK, Yen CJ, et al. Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): A randomised, double-blind, placebo-controlled, phase 3 trial[J]. Lancet Oncol, 2019, 20(2): 282-296.
[32]
El-Khoueiry AB, Sangro B, Yau T, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial[J]. Lancet, 2017, 389(10088): 2492-2502.
[33]
Kudo M, Matilla A, Santoro A, et al. CheckMate 040 cohort 5: A phase Ⅰ/Ⅱ study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis[J]. J Hepatol, 2021, 75(3): 600-609.
[34]
Yau T, Park JW, Finn RS, et al. Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): A randomised, multicentre, open-label, phase 3 trial[J]. Lancet Oncol, 2022, 23(1): 77-90.
[35]
Kim CG, Kim C, Yoon SE, et al. Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma[J]. J Hepatol, 2021, 74(2): 350-359.
[36]
Yau T, Kang YK, Kim TY, et al. Efficacy and safety of nivolumab plus ipilimumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib: the CheckMate 040 randomized clinical trial[J]. JAMA Oncol, 2020, 6(11): e204564.
[37]
Finn RS, Qin S, Ikeda M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma[J]. N Engl J Med, 2020, 382(20): 1894-1905.
[38]
Ren Z, Xu J, Bai Y, et al. Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): A randomised, open-label, phase 2-3 study[J]. Lancet Oncol, 2021, 22(7): 977-990.
[39]
Xu J, Shen J, Gu S, et al. Camrelizumab in combination with apatinib in patients with advanced hepatocellular carcinoma (RESCUE): A nonrandomized, open-label, phase Ⅱ trial[J]. Clin Cancer Res, 2021, 27(4): 1003-1011.
[1] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[2] 曹琮沅, 黄烁金, 何倩婷, 王安训. 平阳霉素复合剂治疗口腔颌面部脉管畸形的有效性和安全性[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 368-374.
[3] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[4] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[5] 刘柏隆, 周祥福. 压力性尿失禁阶梯治疗的项目介绍[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 125-125.
[6] 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126.
[7] 石海波, 赵旭东, 王聪, 曲巍. 气肿性肾盂肾炎、气肿性膀胱炎并脓毒性休克一例报道并文献复习[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 644-647.
[8] 林逸, 钟文龙, 李锴文, 何旺, 林天歆. 广东省医学会泌尿外科疑难病例多学科会诊(第15期)——转移性膀胱癌的综合治疗[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 648-652.
[9] 王秋生. 胆道良性疾病诊疗策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 779-782.
[10] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[11] 中国抗癌协会, 中国抗癌协会大肠癌专业委员会. 中国恶性肿瘤整合诊治指南-肛管癌(2024 版)[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 441-449.
[12] 吴天宇, 刘子璇, 杨浦鑫, 贾思明, 丁凯, 程晓东, 李泳龙, 陈伟, 吕红芝, 张奇. 腰椎间盘突出症保守治疗进展[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(06): 379-384.
[13] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[14] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
[15] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?