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中华普通外科学文献(电子版) ›› 2023, Vol. 17 ›› Issue (02) : 148 -150. doi: 10.3877/cma.j.issn.1674-0793.2023.02.015

综述

长链非编码RNA HOTAIR在肝细胞癌中的研究进展
薛见进1, 周嘉嘉1,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院小儿外科
  • 收稿日期:2022-08-12 出版日期:2023-04-01
  • 通信作者: 周嘉嘉
  • 基金资助:
    国家自然科学基金项目(82073062); 广东省自然科学基金项目(2018A030313624)

Advances of lncRNA HOTAIR in hepatocellular carcinoma progression

Jianjin Xue1, Jiajia Zhou1,()   

  1. 1. Department of Pediatric Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Received:2022-08-12 Published:2023-04-01
  • Corresponding author: Jiajia Zhou
引用本文:

薛见进, 周嘉嘉. 长链非编码RNA HOTAIR在肝细胞癌中的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(02): 148-150.

Jianjin Xue, Jiajia Zhou. Advances of lncRNA HOTAIR in hepatocellular carcinoma progression[J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(02): 148-150.

肝细胞癌是一种常见的肝脏恶性肿瘤,具拥有较高的死亡率。HOX转录反义RNA(HOTAIR)作为被发现的第一个具有反式作用的lncRNA,已被证实在肝癌等多种肿瘤发生、发展中发挥关键调控作用。本文在对HOTAIR概述的基础上,重点对HOTAIR在肝细胞癌中的表达以及对疾病发生、增殖、转移、耐药性和糖代谢等方面的调控作用进行综述。

Hepatocellular carcinoma (HCC) is a common liver malignant tumor with high mortality. HOX transcriptional antisense RNA (HOTAIR), the first identified long non-coding RNA (lncRNA) with a trans role, has been shown to play a key regulatory role in the development and progression of various tumors, including HCC. Based on the overview of HOTAIR, this article focuses on the expression of HOTAIR in HCC and its regulatory role in the carcinogenesis, proliferation, metastasis, drug resistance and glucose metabolism of HCC.

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