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中华普通外科学文献(电子版) ›› 2023, Vol. 17 ›› Issue (04) : 245 -251. doi: 10.3877/cma.j.issn.1674-0793.2023.04.002

论著

实质离断优先在机器人辅助胰体尾切除术中的应用
李嘉诚, 肖均喜, 王道斌, 薛小峰, 秦磊, 侍阳, 张伟刚()   
  1. 215000 苏州大学附属第一医院普外科
  • 收稿日期:2022-12-14 出版日期:2023-08-01
  • 通信作者: 张伟刚

Application of parenchymal priority secure ligation in robotic distal pancreatectomy

Jiacheng Li, Junxi Xiao, Daobin Wang, Xiaofeng Xue, Lei Qin, Yang Shi, Weigang Zhang()   

  1. Department of General Surgery, the First Affiliated Hospital of Suzhou University, Suzhou 215000, China
  • Received:2022-12-14 Published:2023-08-01
  • Corresponding author: Weigang Zhang
引用本文:

李嘉诚, 肖均喜, 王道斌, 薛小峰, 秦磊, 侍阳, 张伟刚. 实质离断优先在机器人辅助胰体尾切除术中的应用[J/OL]. 中华普通外科学文献(电子版), 2023, 17(04): 245-251.

Jiacheng Li, Junxi Xiao, Daobin Wang, Xiaofeng Xue, Lei Qin, Yang Shi, Weigang Zhang. Application of parenchymal priority secure ligation in robotic distal pancreatectomy[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(04): 245-251.

目的

分析实质离断优先的机器人胰体尾切除术(PPRDP)对比应用直线切割闭合器的腹腔镜胰体尾切除术(S-LDP)在短期疗效上是否具备优势。

方法

回顾性分析2017年1月至2022年12月苏州大学附属第一医院接受微创手术切除的胰体尾部占位患者116例,其中PPRDP组38例,S-LDP组78例。收集并对比两组患者的基本资料、围手术期检验结果及影像学资料、术中情况和术后并发症发生率。

结果

PPRDP组较S-LDP组的手术时间更长[(275±70) min vs(240±66) min,P=0.010]、住院总费用更高(79 009元vs 57 921元,P<0.001),但具有更低的B/C级术后胰瘘发生率(18.4% vs 37.2%,P=0.040)以及更短的术后住院时间(7 d vs 9 d,P=0.001)。特别是在胰尾部肿瘤中,PPRDP体现出更低的术中出血量及更多的胰腺实质保留量(均P<0.05)。

结论

PPRDP安全可行,相较于S-LDP手术具有更低的术后胰瘘发生率和更高的保脾效率。对于肿瘤位于胰腺尾部者,PPRDP在保证可靠切缘的同时保留更多的胰腺实质,为胰腺功能的保护提供组织基础。

Objective

To compare and analyze the short-term efficacy of parenchymal priority robotic distal pancreatectomy (PPRDP) with laparoscopic pancreatectomy using stapler (S-LDP).

Methods

From January 2017 to December 2022, 116 patients with distal pancreatic lesions who underwent surgical resection in the First Affiliated Hospital of Suzhou University were retrospectively analyzed, including 38 patients in the PPRDP group and 78 patients in the S-LDP group. The basic data, perioperative data, intraoperative conditions, and postoperative complications were collected and compared.

Results

Compared with group S-LDP, group PPRDP had longer operation time [(275±70) min vs (240±66) min, P=0.010] and higher total hospitalization costs (79 009 yuan vs 57 921 yuan, P<0.001), but lower incidence of postoperative pancreatic fistula (18.4% vs 37.2%, P=0.040) and shorter postoperative hospital stays (7 d vs 9 d, P=0.001). Especially in pancreatic tail tumors, PPRDP exhibited lower intraoperative blood loss and more pancreatic parenchymal retention (both P<0.05).

Conclusions

PPRDP has more reliable sealing effect on pancreatic stumps and can reduce the incidence of postoperative pancreatic fistula than S-LDP. For patients with tumors located in the tail of the pancreas, PPRDP can ensure a negative surgical margin while retaining more pancreatic parenchyma, which may reduce the damage to pancreatic function in patients.

表1 两组胰体尾部占位患者的基本资料比较
图1 PPRDP操作孔布局示意图 1、2、4对应机器人的1、2、4号机械臂;A为助手孔;C为观察孔,由3号机械臂负责
图3 实质离断优先的机器人胰体尾切除术(Kimura) 胰腺下缘分离(A),胰腺实质离断(B),胰腺断面背侧分离显露脾动静脉(C),沿脾血管分离远端胰腺(D),5-0 prolene缝闭主胰管(E),单纯间断缝合关闭胰腺残端(F)
图4 实质离断优先的机器人胰体尾癌根治术 胰腺上缘7、8、9组廓清(A),胰腺下缘分离(B),实质离断及主胰管显露(C),后腹膜廓清(D),5-0 prolene U型缝闭主胰管(E),单纯间断缝合关闭胰腺残端(F)
图2 根据患者术后影像学复查标定切线,测量术前影像切线投影处胰腺厚度(箭头所示) A、B为胰腺尾部良性占位手术前后对照;C、D为胰腺体部恶性占位手术前后对照
表2 两组患者手术相关指标比较
项目 倾向性评分匹配前 倾向性评分匹配后
PPRDP组 S-LDP组 P PPRDP组 S-LDP组 P
例数 38 78   33 33  
手术时间(min)a 275±70 240±66 0.010 276±73 234±77 0.032
术中出血量(ml) b 100(50~208) 150(100~200) 0.668 100(50~215) 150(50~200) 0.770
中转开腹[例(%)] 3(7.9) 5(6.4) 0.716 3(9.1) 3(9.1) 1.000
合并脏器切除[例(%)] 3(7.9) 3(3.8) 0.392 3(9.1) 1(3.0) 1.000
预计保脾[例(%)] 14(36.8) 46(59.0) 0.030 13(39.4) 16(48.5) 0.457
保脾成功率[例(%)] 11(78.6) 26(56.5) 0.065 11(84.6) 6(37.5) 0.022
R0切除[例(%)] 37(97.4) 78(100.0) 0.328 32(97.0) 33(100.0) 1.000
肿瘤位置(体部/尾部,例) 28/10 20/58 <0.001 25/8 12/21 0.003
主胰管缝扎[例(%)] 27(71.1) 0(0) <0.001 24(72.7) 0(0) <0.001
胰腺断端厚度(mm) b 18(12~22) 15(11~18) 0.106 18(13~22) 15(12~18) 0.130
残余胰腺长度(mm)b 53(39~69) 50(32~71) 0.377 52(39~70) 52(32~67) 0.401
术后并发症[例(%)]            
Ⅱ~Ⅲa 3(7.9) 5(6.4) 0.716 2(6.1) 1(3.0) 1.000
≥Ⅲb 4(10.5) 3(3.8) 0.214 4(12.1) 3(9.1) 1.000
围手术期死亡[例(%)] 0(0) 1(1.3) 1.000 0(0) 1(3.0) 1.000
术后住院时间(d) b 7(6.0~9.0) 9(8.0~12.0) 0.001 7(6.0~9.0) 10(8.0~11.0) 0.004
30 d再住院[例(%)] 3(7.9) 6(7.7) 1.000 2(6.1) 2(6.1) 1.000
术后胰瘘B/C级[例(%)] 7(18.4) 29(37.2) 0.040 4(12.1) 12(36.4) 0.042
内分泌功能受损[例(%)] 4(10.5) 10(12.8) 0.774 4(12.1) 9(27.3) 0.215
住院总费用(元) b 79 009(71 527~88 322) 57 921(49 479~69 056) <0.001 78 601(71 259~89 207) 63 007(50 523~73 020) <0.001
表3 胰体和胰尾切除的手术相关指标比较
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