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中华普通外科学文献(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 14 -17. doi: 10.3877/cma.j.issn.1674-0793.2024.01.002

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PIK3CA基因在结直肠癌中的意义
陈劲松(), 陈锦旭, 张凯   
  1. 510120 广州医科大学附属第一医院胃肠外科
  • 收稿日期:2023-04-30 出版日期:2024-02-01
  • 通信作者: 陈劲松
  • 基金资助:
    国家自然科学基金项目(82072620); 广东省基础与应用基础研究基金项目(2021A1515011357); 广州市科技计划项目(202102010158)

Significance of phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha gene in colorectal cancer

Jinsong Chen(), Jinxu Chen, Kai Zhang   

  • Received:2023-04-30 Published:2024-02-01
  • Corresponding author: Jinsong Chen
引用本文:

陈劲松, 陈锦旭, 张凯. PIK3CA基因在结直肠癌中的意义[J]. 中华普通外科学文献(电子版), 2024, 18(01): 14-17.

Jinsong Chen, Jinxu Chen, Kai Zhang. Significance of phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha gene in colorectal cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(01): 14-17.

结直肠癌(colorectal cancer,CRC)是最常见的恶性肿瘤之一。据统计,在全世界范围内,其发病率居第三位,死亡率居第二位[1]。我国CRC发病率和死亡率呈逐年上升趋势,目前已经是第二常见的恶性肿瘤,仅2020年就导致约28.6万人死亡[2]。在CRC发生发展过程中,多种细胞信号转导通路参与其中,主要有磷脂酰肌醇-3-激酶(phosphatidylinositol 3-kinase,PI3K)/AKT信号通路、Wnt/β-连环蛋白(β-catenin)信号通路、转化生长因子β(transforming growth factor-beta,TGF-β)信号通路、Ras/RAF/MAPK信号通路等。其中,PI3K/AKT信号通路的异常激活起着非常重要的作用。而作为该通路中的关键基因,磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基α(phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha gene,PIK3CA)也逐渐被人们所认识并研究。

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