切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 58 -61. doi: 10.3877/cma.j.issn.1674-0793.2024.01.011

综述

肿瘤相关中性粒细胞在胃癌发生发展和治疗中的研究进展
尚峰进, 陈陆尧, 刘亚星, 张浩然, 连长红()   
  1. 046000 长治医学院附属和平医院胃肠外科;046000 长治医学院第一临床学院
    046000 长治医学院附属和平医院胃肠外科
  • 收稿日期:2023-06-16 出版日期:2024-02-01
  • 通信作者: 连长红
  • 基金资助:
    山西省研究生实践创新项目(2023SJ304)

Research progress on tumor associated neutrophils in the occurrence, development, and treatment of gastric cancer

Fengjin Shang, Luyao Chen, Yaxing Liu, Haoran Zhang, Changhong Lian()   

  1. Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China; The First Clinical College of Changzhi Medical College, Changzhi 046000, China
    Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
  • Received:2023-06-16 Published:2024-02-01
  • Corresponding author: Changhong Lian
引用本文:

尚峰进, 陈陆尧, 刘亚星, 张浩然, 连长红. 肿瘤相关中性粒细胞在胃癌发生发展和治疗中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(01): 58-61.

Fengjin Shang, Luyao Chen, Yaxing Liu, Haoran Zhang, Changhong Lian. Research progress on tumor associated neutrophils in the occurrence, development, and treatment of gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(01): 58-61.

迄今为止,胃癌的发病机制尚未完全明了。研究表明,肿瘤微环境(TME)对于肿瘤的发生和发展至关重要。TME中的肿瘤相关中性粒细胞(TANs)参与肿瘤进展的所有阶段,包括肿瘤起始、转移和免疫抑制,其复杂的作用机制增加了治疗胃癌的困难。随着对TME的深入研究,特异的治疗措施有望成为胃癌治疗的新希望。本文通过近年来文献回顾,研究和总结TANs在胃癌发生和转移中所起的作用,并阐述未来免疫治疗的发展方向,以期为临床和科研提供参考。

So far, the pathogenesis of gastric cancer (GC) has not been fully understood. Research shows that tumor microenvironment (TME) is essential for the occurrence and development of tumors. Tumor associated neutrophils (TANs) in TME are involved in all stages of tumor progression, including tumor initiation, metastasis, and immunosuppression. Due to the complex mechanism of TANs, the treatment of GC faces great challenges. With in-depth research on TME, specific treatment measures are expected for clinical treatment of GC. This article intends to review the literature in recent years, study and summarize the role of TANs in the occurrence and metastasis of GC, and briefly describe the development direction of targeted therapy in the future, trying to provide reference for clinical and scientific research.

[1]
Liu S, Deng Z, Zhu J, et al. Gastric immune homeostasis imbalance: An important factor in the development of gastric mucosal diseases[J]. Biomed Pharmacother, 2023, 161: 114338.
[2]
de Visser KE, Joyce JA. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth[J]. Cancer Cell, 2023, 41(3): 374-403.
[3]
Siwicki M, Pittet MJ. Versatile neutrophil functions in cancer[J]. Semin Immunol, 2021, 57: 101538.
[4]
Li S, Cong X, Gao H, et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells[J]. J Exp Clin Cancer Res, 2019, 38(1): 177.
[5]
Wu L, Saxena S, Awaji M, et al. Tumor-associated neutrophils in cancer: going pro[J]. Cancers (Basel), 2019, 11(4): 564.
[6]
Coffelt SB, Wellenstein MD, de Visser KE. Neutrophils in cancer: neutral no more[J]. Nat Rev Cancer, 2016, 16(7): 431-446.
[7]
Sağlam , Civan HA. Impact of chronic Helicobacter pylori infection on inflammatory markers and hematological parameters[J]. Eur Rev Med Pharmacol Sci, 2023, 27(3): 969-979.
[8]
Cani PD, Jordan BF. Gut microbiota-mediated inflammation in obesity: A link with gastrointestinal cancer[J]. Nat Rev Gastroenterol Hepatol, 2018, 15(11): 671-682.
[9]
Que H, Fu Q, Lan T, et al. Tumor-associated neutrophils and neutrophil-targeted cancer therapies[J]. Biochim Biophys Acta Rev Cancer, 2022, 1877(5): 188762.
[10]
牛世伟, 龚红霞, 付晓燕, 等. IL-17及其介导的信号通路在胃癌中的研究进展[J]. 医学研究生学报, 2022, 35(6): 660-663.
[11]
Mei H, Wang D, Zhang Y. The tumor-associated neutrophils secrete LOX and MMP to promote tumor angiogenesis in gastric cancer bearing mice model[C]//第十七届国际免疫学大会, 北京, 2019[2023-06-16].
[12]
Mao Z, Zhang J, Shi Y, et al. CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils [J]. Oncogenesis, 2020, 9(7): 63.
[13]
Zhang W, Gu J, Chen J, et al. Interaction with neutrophils promotes gastric cancer cell migration and invasion by inducing epithelial-mesenchymal transition[J]. Oncol Rep, 2017, 38(5): 2959-2966.
[14]
Zhang X, Shi H, Yuan X, et al. Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration[J]. Mol Cancer, 2018, 17(1): 146.
[15]
Wang Y, Li X, Zhang T, et al. Neutrophils promote tumor invasion via FAM3C-mediated epithelial-to-mesenchymal transition in gastric cancer[J]. Int J Biol Sci, 2023, 19(5): 1352-1368.
[16]
Shan ZG, Chen J, Liu JS, et al. Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-α-B7-H2-dependent pathway in human gastric cancer[J]. Clin Transl Med, 2021, 11(6): e484.
[17]
Wang TT, Zhao YL, Peng LS, et al. Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway[J]. Gut, 2017, 66(11): 1900-1911.
[18]
Zhao Y, Bai Y, Shen M, et al. Therapeutic strategies for gastric cancer targeting immune cells: future directions [J]. Front Immunol, 2022, 13: 992762.
[19]
Basu A, Ramamoorthi G, Albert G, et al. Differentiation and regulation of T(H) cells: A balancing act for cancer immunotherapy[J]. Front Immunol, 2021, 12: 669474.
[20]
Keeley T, Costanzo-Garvey DL, Cook LM. Unmasking the many faces of tumor-associated neutrophils and macrophages: considerations for targeting innate immune cells in cancer[J]. Trends Cancer, 2019, 5(12): 789-798.
[21]
Powell D, Lou M, Barros Becker F, et al. Cxcr1 mediates recruitment of neutrophils and supports proliferation of tumor-initiating astrocytes in vivo[J]. Sci Rep, 2018, 8(1): 13285.
[22]
Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment[J]. Blood, 2019, 133(20): 2159-2167.
[23]
Liu Q, Yu S, Li A, et al. Targeting interlukin-6 to relieve immunosuppression in tumor microenvironment[J]. Tumour Biol, 2017, 39(6): 1010428317712445.
[24]
Zhang Y, He S, Xu C, et al. An activatable polymeric nanoprobe for fluorescence and photoacoustic imaging of tumor-associated neutrophils in cancer immunotherapy[J]. Angew Chem Int Ed Engl, 2022, 61(27): e202203184.
[1] 李国新, 陈新华. 全腹腔镜下全胃切除术食管空肠吻合的临床研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 1-4.
[2] 陈方鹏, 杨大伟, 金从稳. 腹腔镜近端胃癌切除术联合改良食管胃吻合术重建His角对术后反流性食管炎的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 15-18.
[3] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[4] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[5] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[6] 任佳, 马胜辉, 王馨, 石秀霞, 蔡淑云. 腹腔镜全胃切除、间置空肠代胃术的临床观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 31-34.
[7] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[8] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[9] 贺斌, 马晋峰. 胃癌脾门淋巴结转移危险因素[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 694-699.
[10] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[11] 刘海旺, 施海, 尚利峰. 不同吻合器在腹腔镜远端胃癌根治术Roux-en-Y式吻合中的应用对比[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 643-646.
[12] 许杰, 李亚俊, 冯义文. SOX新辅助化疗后腹腔镜胃癌D2根治术与常规根治术治疗进展期胃癌的近期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 647-650.
[13] 林逸, 钟文龙, 李锴文, 何旺, 林天歆. 广东省医学会泌尿外科疑难病例多学科会诊(第15期)——转移性膀胱癌的综合治疗[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 648-652.
[14] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[15] 王昌前, 林婷婷, 宁雨露, 王颖杰, 谭文勇. 光免疫治疗在肿瘤领域的临床应用新进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 575-583.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?