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中华普通外科学文献(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 127 -132. doi: 10.3877/cma.j.issn.1674-0793.2026.02.010

综述

免疫检查点抑制剂新辅助治疗在肝细胞癌肝移植中的应用
刘建勇, 江艺()   
  1. 350025 福州,中国人民解放军联勤保障部队第九〇〇医院肝胆外科
  • 收稿日期:2025-09-22 出版日期:2026-04-01
  • 通信作者: 江艺
  • 基金资助:
    器官移植重点学科支撑专项项目(2023XKYZ02)

Application of immune checkpoint inhibitors neoadjuvant therapy in liver transplantation for hepatocellular carcinoma

Jianyong Liu, Yi Jiang()   

  1. Department of Hepatobiliary Surgery, the 900th Hospital of PLA Joint Logistics Force, Fuzhou 350025, China
  • Received:2025-09-22 Published:2026-04-01
  • Corresponding author: Yi Jiang
引用本文:

刘建勇, 江艺. 免疫检查点抑制剂新辅助治疗在肝细胞癌肝移植中的应用[J/OL]. 中华普通外科学文献(电子版), 2026, 20(02): 127-132.

Jianyong Liu, Yi Jiang. Application of immune checkpoint inhibitors neoadjuvant therapy in liver transplantation for hepatocellular carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2026, 20(02): 127-132.

免疫检查点抑制剂(ICIs)作为肿瘤免疫治疗的重要突破,在肝细胞癌(HCC)系统治疗中展现出显著疗效。近年来,ICIs新辅助治疗在HCC肝移植中的应用也成为热点话题,旨在通过术前免疫激活降低肿瘤负荷、改善移植预后。然而,ICIs可能加剧移植后免疫排斥反应,其安全性和有效性仍需谨慎评估。本文基于国内外最新研究进展,对ICIs新辅助治疗在HCC肝移植中的应用现状及热点问题进行综述。

Immune checkpoint inhibitors (ICIs), as a major breakthrough in cancer immunotherapy, have demonstrated significant efficacy in the systemic treatment of hepatocellular carcinoma (HCC). In recent years, the application of neoadjuvant therapy with ICIs in liver transplantation for HCC has become a hot topic, aiming to reduce tumor burden and improve transplant outcomes through pre-operative immune activation. However, ICIs may exacerbate post-transplant immune rejection, and their safety and efficacy still require careful evaluation. Based on the latest domestic and international research progress, this article reviews the current status and key issues regarding the application of neoadjuvant therapy with ICIs in liver transplantation for HCC.

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