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中华普通外科学文献(电子版) ›› 2023, Vol. 17 ›› Issue (04) : 311 -315. doi: 10.3877/cma.j.issn.1674-0793.2023.04.017

综述

肥胖合并甲状腺癌相关机制的研究进展
李永浩, 高雪菲, 郭田田, 张进, 张彩针, 刘静()   
  1. 030000 太原,山西医科大学第一临床医学院
    030000 太原,山西医科大学第一医院甲状腺外科
  • 收稿日期:2022-12-21 出版日期:2023-08-01
  • 通信作者: 刘静
  • 基金资助:
    "四个一批"山西省医学科技创新团队建设项目(甲状腺癌临床诊治和基础研究创新团队)(2020TD16)

Advances in the research of mechanisms related to obesity combined with thyroid carcinoma

Yonghao Li, Xuefei Gao, Tiantian Guo, Jin Zhang, Caizhen Zhang, Jing Liu()   

  1. The First Clinical School of Shanxi Medical University, Taiyuan 030000, China
    Department of Thyroid Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030000, China
  • Received:2022-12-21 Published:2023-08-01
  • Corresponding author: Jing Liu
引用本文:

李永浩, 高雪菲, 郭田田, 张进, 张彩针, 刘静. 肥胖合并甲状腺癌相关机制的研究进展[J/OL]. 中华普通外科学文献(电子版), 2023, 17(04): 311-315.

Yonghao Li, Xuefei Gao, Tiantian Guo, Jin Zhang, Caizhen Zhang, Jing Liu. Advances in the research of mechanisms related to obesity combined with thyroid carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(04): 311-315.

近年来甲状腺癌的发病率逐年上升,而全球肥胖群体的数量也在同步增长。研究认为肥胖是甲状腺癌可能的风险因素,其中白细胞介素6、肿瘤坏死因子α、瘦素、脂联素、雌激素和促甲状腺激素均与甲状腺癌的发生发展有关,同时胰岛素抵抗和肠道菌群异常等代谢失调也以直接或间接作用促进甲状腺癌进展。尽管如此,肥胖合并甲状腺癌的相关致病机制尚不清楚。本综述通过阐述肥胖合并甲状腺癌的发生机制,以便为今后的基础和临床研究提供参考。

In recent years, the incidence of thyroid carcinoma has been increasing year by year, and the number of obese people worldwide is also increasing in parallel. Studies have identified obesity as a possible risk factor for thyroid cancer, in which interleukin 6, tumor necrosis factor alpha, leptin, adiponectin, estrogen and thyroid stimulating hormone are all associated with the development of thyroid carcinoma, while metabolic dysregulation such as insulin resistance and dysbiosis of intestinal flora also promote the development of thyroid carcinoma by indirect or direct effects. The progression of thyroid carcinoma is also facilitated by metabolic disorders such as insulin resistance and intestinal flora. Nevertheless, the pathogenic mechanisms associated with obesity combined with thyroid carcinoma are still unclear. In this review, we have searched the relevant literature in the past 5 years to describe the mechanisms of thyroid cancer in combination with obesity, in order to provide reference for future basic and clinical research.

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