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中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (03) : 197 -200. doi: 10.3877/cma.j.issn.1647-0793.2013.03.008

所属专题: 文献

论著

乌司他丁对胃癌患者术后炎症反应的影响
冯春在1, 苏永辉2, 侯冰宗2,(), 李继延1, 王尧1, 陈宏1   
  1. 1. 528400 中山市人民医院胃肠外科
    2. 中山大学附属第五医院
  • 收稿日期:2013-01-26 出版日期:2013-06-01
  • 通信作者: 侯冰宗

Effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer

Chun-zai FENG1, Yong-hui SU2, Bing-zong HOU2,(), Ji-yan LI1, Yao WANG1, Hong CHEN1   

  1. 1. Gastrointestinal Surgery, the People's Hospital of Zhongshan, Zhongshan 528400, China
  • Received:2013-01-26 Published:2013-06-01
  • Corresponding author: Bing-zong HOU
  • About author:
    Corresponding author: HOU Bing-zong, Email:
引用本文:

冯春在, 苏永辉, 侯冰宗, 李继延, 王尧, 陈宏. 乌司他丁对胃癌患者术后炎症反应的影响[J/OL]. 中华普通外科学文献(电子版), 2013, 07(03): 197-200.

Chun-zai FENG, Yong-hui SU, Bing-zong HOU, Ji-yan LI, Yao WANG, Hong CHEN. Effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 197-200.

目的

观察乌司他丁对胃癌术后机体炎症反应的影响。

方法

选择2011年6月至2012年6月因胃癌行胃癌根治术患者52例,随机双盲分为试验组(28例)和对照组(24例)。试验组在手术当天至术后第3天,每天给予乌司他丁(UTI)1×105 U静脉滴注,每天2次;对照组则以等量生理盐水静脉注射。所有患者在术前1 d及术后1,2,3,6 d空腹抽血检测白介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平和血白细胞(WBC)计数,并进行全身炎症反应综合征(SIRS)评分。

结果

两组患者术后IL-6、TNF-α、血白细胞水平及SIRS评分在术后1,2,3 d均较术前明显升高(P < 0.05),试验组与对照组术后在WBC计数及SIRS评分差异无统计学意义。试验组在术后1,2,3 d血清IL-6、TNF-α水平明显低于对照组(P < 0.05)。

结论

胃癌患者术后存在炎症反应,乌司他丁可降低胃癌患者术后血清IL-6、TNF-α的浓度。

Objective

To study the effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer.

Methods

From June 2011 to June 2012, 52 patients underwent radical gastrectomy for gastric cancer were randomized to two groups in double-blind manner: trial group(28 cases) and control group(24 cases). Patients in the trial groups were subjected to intravenous infusion of 100 000 U of Ulinastatin (UTI) twice a day on the postoperative day 0-3, and those in the control group were injected the same volume of saline. The level of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) counts in blood samples were measured before surgery and the 1st, 2nd, 3rd, 6th day after surgery. The systemic inflammatory response syndrome (SIRS) score was also commented.

Results

Postoperative IL-6, TNF-α, WBC counts and SIRS score were significantly higher on the 1st, 2nd and 3rd day after surgery compared with the day before surgery (P < 0.05). There was no significant difference after srygery between the trial group and the control group in WBC counts and SIRS score. While the serum IL-6 and TNF-α level was significantly lower on the 1st, 2nd and 3rd day after surgery in experimental group compared with the control group (P < 0.05).

Conclusions

Inflammatory response occurs after suygery in Gastric cancer patients. Ulinastatin could inhibit the postoperative serum IL-6, TNF-α concentration.

表1 两组患者术前1 d与术后1, 2, 3, 6 d血清IL-6水平(pg/ml,±s
表2 两组患者术前1 d与术后1, 2, 3, 6 d血清TNF-α水平(pg/ml,±s
表3 两组患者术前1 d与术后1, 2, 3, 6 d WBC计数(×109/L,±s
表4 两组患者术前1 d与术后1, 2, 3, 6 d SIRS评分
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