切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (03) : 201 -205. doi: 10.3877/cma.j.issn.1647-0793.2013.03.009

所属专题: 经典病例 文献

论著

残胃癌41例临床病理特征及生存分析
李引1, 何裕隆1,(), 蔡世荣1, 崔冀1, 陈剑辉1, 杨东杰1, 卢励锋1   
  1. 1. 510080 广州,中山大学附属第一医院胃肠外科
  • 收稿日期:2012-09-02 出版日期:2013-06-01
  • 通信作者: 何裕隆

Clinical-pathological feature and survival of gastric stump carcinoma: an analysis of 41 cases

Yin LI1, Yu-long HE1,(), Shi-rong CAI1, Ji CUI1, Jian-hui CHEN1, Dong-jie YANG1, Li-feng LU1   

  1. 1. Division of Gastrointestinal & Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2012-09-02 Published:2013-06-01
  • Corresponding author: Yu-long HE
  • About author:
    Corresponding author: HE Yu-long, Email:
引用本文:

李引, 何裕隆, 蔡世荣, 崔冀, 陈剑辉, 杨东杰, 卢励锋. 残胃癌41例临床病理特征及生存分析[J/OL]. 中华普通外科学文献(电子版), 2013, 07(03): 201-205.

Yin LI, Yu-long HE, Shi-rong CAI, Ji CUI, Jian-hui CHEN, Dong-jie YANG, Li-feng LU. Clinical-pathological feature and survival of gastric stump carcinoma: an analysis of 41 cases[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 201-205.

目的

探讨残胃癌(GSC)临床病理特征及影响生存预后的因素。

方法

追踪并随访中山大学附属第一医院1998年1月至2010年2月的49例GSC患者,分析其临床病理特征及可能影响生存的因素。

结果

收集有效GSC病例41例(男37例,90.24%),中位发病年龄66岁,初次手术至GSC发生的平均病程为25年,且随年龄的增长有缩短趋势(P = 0.003);患者年龄越小,GSC的病理分期越高(P < 0.01),组织分化程度越低;多数GSC伴淋巴结的转移(60.98%),5年生存率37.00%。Cox比例风险模型生存分析显示,临床病理分期对生存预后的影响有统计学意义(P = 0.004)。

结论

残胃癌是病理类型相对特殊的一类胃癌,手术根治是提高残胃癌生存预后的关键。

Objective

To study the clinical feature and prognosis of gastric stump carcinoma (GSC).

Methods

A retrospective study was performed by following GSC cases diagnosed at the First Affiliated Hospital of Sun Yat-sen University between January, 1998 and February, 2010. The clinical feature and potential prognostic factors were analyzed.

Results

Forty-one GSC cases (male 37, 90.24%) were collected, with a 66-year median age, and an average 25-year interval between primary operation and GSC occurrence, which was negatively correlated with aging (P = 0.003). The younger of GSC patients, the higher of pathological stages and the lower of the differentiation degrees (P = 0.004). Most GSC was complicated with lymph nodes metastasis (60.98%). The 5-year survival rate was 37.00%. Cox proportional hazards model for survival analysis indicated that the clinical-pathological stage significantly affected survival and prognosis.

Conclusion

Regular gastroscopy is important to improve the quality of life in patients accepted subtotal gastrectomy.

表1 GSC组织病理分期及手术方式
图1 初次手术年龄与残胃癌的累积概率关系
图2 GSC发病年龄分布
图3 初次手术年龄与GSC病程的关系
表2 GSC组织病理分期及手术方式
图4 GSC术后Kaplan-Meier生存曲线
1
陈峻青. 残胃癌早期诊断与现代外科治疗. 中国实用外科杂志, 2004, 24(7): 394-395.
2
Kodera Y, Yamamura Y, Torii A, et al. Gastric remnant carcinoma after partial gastrectomy for benign and malignant gastric lesions.J Am Coil Surg, 1996, 182(1): 1-6.
3
Sinning C, Schaefer N, Standop J, et al. Gastric stump carcinoma - epidemiology and current concepts in pathogenesis and treatment. Eur J Surg Oncol,2007, 33(2): 133-139.
4
Nishidoi H, Koga S, Kaibara N. Possible role of duodenogastric reflux on the development of remnant gastric carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. J Nat Cancer Inst, 1984, 72(6): 1431-1435.
5
K Fukuhara K, Osugi H, Takada N, et al. Reconstructive procedure after distal gastrectomy for gastric cancer that best prevents duodenogastroesophageal reflux. World J Surg, 2002, 26(12): 1452-1457.
6
Lee HJ, Yang HK, Ahn YO. Gastric cancer in Korea. Gastric Cancer, 2002, 5(3): 177-182.
7
Onoda N, Katsuragi K, Sawada T, et al. Efficacy of Helicobacter pylori eradication on the chronic mucosal inflammation of the remnant stomach after distal gastrectomy for early gastric cancer. J Exp Clin Cancer Res, 2005, 24(4): 515-521.
8
江一鸣,黄开红,李楚强, 等. 残胃癌的临床特征及预后分析. 现代消化及介入诊疗, 2007, 12(2): 82-84.
9
Wonshik Han, So Young Kang. Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer. Breast Cancer Res Treat, 2010, 119(1): 193-200.
10
Chai X, Wang C, Li Y. The early diagnosis and surgical treatment of the gastric stump carcinoma. J Tongji Med Univ, 2000, 20(4): 315-317.
11
周军,江志鹏,杨斌, 等. 残胃复发癌30例的外科治疗及其预后分析[J/CD]. 中华普通外科学文献:电子版, 2010, 4(3): 228-231.
12
杜义安,郭剑民,张云利, 等. 残胃复发癌60例的外科治疗及其生存分析. 中华胃肠外科杂志, 2005, 7(8): 313-315.
13
Yonemura Y, Ninomiya I, Tsugawa K, et al. Lymph node metastases from carcinoma of the gastric stump. Hepatogastroenterology, 1994, 41(3): 248-252.
14
Han SL, Hua YW, Wang CH, et al. Metastatic pattern of lymph node and surgery for gastric stump cancer. Surg Oncol, 2003, 82(4): 241-246.
15
Kunisaki C, Shimada H, Nomura M, et al. Lymph node dissection insurgical treatment for remnant stomach cancer. Hepatogastroenterology, 2002, 49(44): 580-584.
[1] 吴令杰, 陈瑞烈, 肖湘明, 郭耿龙, 林钟滨, 张海生, 周敏, 陈妙华. 2005至2021年广东省汕头市某综合医院人类免疫缺陷病毒感染/获得性免疫缺陷综合征患者流行病学特征及高效抗逆转录病毒治疗后生存状况影响因素[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 207-214.
[2] 李雪, 韩萌萌, 冯雪园, 马宁. 人表皮生长因子受体2低表达乳腺癌的研究进展及挑战[J/OL]. 中华普通外科学文献(电子版), 2024, 18(04): 308-312.
[3] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[4] 黄福, 王黔, 金相任, 唐云川. VEGFR2、miR-27a-5p在胃癌组织中的表达与临床病理参数及预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 558-561.
[5] 孙建娜, 孔令军, 任崇禧, 穆坤, 王晓蕊. 266例首诊Ⅳ期乳腺癌手术患者预后分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 502-505.
[6] 蔡大明, 陆晓峰, 王行舟, 王萌, 刘颂, 夏雪峰, 沈晓菲, 杜峻峰, 管文贤. 三级淋巴结构在胃神经内分泌瘤中的预后价值及预后预测模型构建[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 401-405.
[7] 乌吉斯古楞, 哈斯高娃. mir-98-5p、ALKBH1在肝门部胆管癌组织中表达及与临床病理特征的关系[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 184-187.
[8] 公宇, 廖媛, 尚梅. 肝细胞癌TACE术后复发影响因素及预测模型建立[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 818-824.
[9] 王凯飞, 牟怡平, 李晓辉, 王瑞涛, 侯惠莲, 张月浪. 原发性肝平滑肌肉瘤临床病理特征及疗效分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(03): 357-362.
[10] 王礼光, 严庆, 廖珊, 符荣党, 陈焕伟. 微血管侵犯及手术切缘对肝细胞癌患者术后生存预后的影响[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(02): 151-157.
[11] 朱军, 宋家伟, 乔一桓, 郭雅婕, 刘帅, 姜玉, 李纪鹏. M2型巨噬细胞特征基因与结肠癌免疫微环境研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 303-311.
[12] 程璞, 郑朝旭. 伴有错配修复缺陷的病理Ⅱ期结直肠癌临床病理特征分析及生存分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(03): 236-241.
[13] 孙鼎, 王滨, 陈香美, 陈意志. 热应激肾病的研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(03): 170-176.
[14] 丁富贵, 吴泽涛, 董卫国. 家族性腺瘤性息肉病临床特征及生物信息学分析[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 512-518.
[15] 董宁宁, 孟凡冬, 岳冰, 侯俊珍. 消化道幽门腺腺瘤的临床、内镜及病理特征分析[J/OL]. 中华胃肠内镜电子杂志, 2024, 11(03): 159-165.
阅读次数
全文


摘要