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中华普通外科学文献(电子版) ›› 2008, Vol. 02 ›› Issue (02) : 117 -120. doi: 10.3877/cma.j.issn.1674-0793.2008.02.008

论著

乳腺癌ER、PR、p53、Her-2表达与新辅助化疗有效率的关系
刘瑞磊1,(), 吕伟明2, 卫洪波1, 王佳妮2, 黄勇1, 李杰2, 廖艺2   
  1. 1.510000 广州,中山大学附属第三医院乳腺甲状腺外科
    2.中山大学附属第一医院乳腺外科
  • 收稿日期:2008-02-02 出版日期:2008-04-01
  • 通信作者: 刘瑞磊

Relationship between expression of ER,PR,p53,Her-2 and the effective rate of neoadjuvant chemotherapy in breast cancer

Rui-lei LIU1,(), Wei-ming LV1, Hong-bo WEI1, Jia-ni WANG1, Yong HUANG1, Jie LI1, Yi LIAO1   

  1. 1.the Third Affiliated Hospital of Sun Yat-sen university,Guangzhou 510000,China
  • Received:2008-02-02 Published:2008-04-01
  • Corresponding author: Rui-lei LIU
引用本文:

刘瑞磊, 吕伟明, 卫洪波, 王佳妮, 黄勇, 李杰, 廖艺. 乳腺癌ER、PR、p53、Her-2表达与新辅助化疗有效率的关系[J/OL]. 中华普通外科学文献(电子版), 2008, 02(02): 117-120.

Rui-lei LIU, Wei-ming LV, Hong-bo WEI, Jia-ni WANG, Yong HUANG, Jie LI, Yi LIAO. Relationship between expression of ER,PR,p53,Her-2 and the effective rate of neoadjuvant chemotherapy in breast cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(02): 117-120.

目的

探讨乳腺癌患者ER、PR、p53、Her-2 的表达及其与新辅助化疗有效率的关系。

方法

采用免疫组化的方法检测178例乳腺癌新辅助化疗患者化疗前ER、PR、p53、Her-2的表达情况,观察新辅助化疗的效果。

结果

178例乳腺癌新辅助化疗病例中,ER、PR、p53阴性率、Her-2过度表达率分别为33.15、23.60%、60.67%、35.39%。ER(+)组与ER(-)组、PR(+)组与PR(-)组、p53(+)组与p53(-)组化疗有效率差异均有统计学意义(P<0.05),Her-2过度表达组与非过度表达组化疗有效率差异无统计学意义(P>0.05)。

结论

ER、PR、p53阴性的乳腺癌病人对化疗更敏感,化疗后获益更多, ER、PR、p53可作为乳腺癌新辅助化疗(TE或CET方案)敏感性的预测指标。

Objective

To investigate the relationship between the expressions of ER,PR,p53 and Her-2 with the effective rate of neoadjuvant chemotherapy for breast cancer.

Methods

Expression of ER, PR, p53 and Her-2 in breast cancer of 178 patients received neoadjuvant chemotherapy were detected by immunohistochemical method before chemotherapy.

Results

Among the 178 cases of neoadjvant chemotherapy , the percentage of negative for ER, PR, p53 and over expression for Her-2 were 33.15%, 23.60%, 60.67%,35.39%respectively.In the differences of chemotherapeutic effective rate between ER negative and ER positive,PR negative and PR positive, p53 negative and p53 positive, there were statistical significance (P<0.05). But between Her-2 overexpressed group and Her-2 non-overexpressed group, there were not statistical significance(P>0.05).

Conclusion

In the patients with breast cancer, ER,PR or p53 negative are more sensitive to chemotherapy. These patients may get more benefits from chemotherapy. ER, PR and p53 can be considered as predictive markers of the effective rate of neoadjuvant chemotherapy.

表1 化疗前ER、PR、P53、Her-2表达与化疗疗效的关系(例)
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