目的

评价曲马多及氟比洛芬脂用于肠道手术后患者自控镇痛（PCA）的安全性及有效性。

方法

50例在全麻下行肠道肿瘤切除术的患者，随机分为曲马多组（T组）和氟比洛芬脂组（F组），每组各25例。将所配制药液注入PCA泵，设定PCA泵给药速率为2 ml/h，术毕半小时前F组静注氟比洛芬脂50 mg以及T组静注曲马多100 mg作为镇痛首量，术毕时启动PCA泵进行镇痛，镇痛完毕后由患者对镇痛治疗总体印象评分，并记录发生的副作用。

结果

在患者镇痛总体印象评分中，F组镇痛满意的比例略高于T组，但无统计学差异。F组患者头晕的发生率为0，明显低于曲马多组（32%）；T组恶心与呕吐的发生率占44%，明显高于F组（4%）（P＜0.05）。

结论

氟比洛芬脂用于肠道肿瘤切除术后PCA的效果与曲马多接近，但副作用少，更适用于急性疼痛的治疗。

Objective

To assess the analgesic efficacy and safety of patient-controlled analgesia with tramadol or flurbiprofen axetil in patients undergoing intestinectomy.

Methods

50 patients scheduled for intestinectomy under general anesthesia were randomly allocated to flurbiprofen axetil(Group F)and tramadol(Group T)for postoperative patient-controlled analgesia(PCA). Efficacy was assessed by a 5-point verbal rating scores of pain intensity. Possible adverse events were also recorded.

Results

Statistical analysis revealed no significant difference in a 5-point verbal rating scores of pain intensity between flurbiprofen axetil and tramadol.Flurbiprofen axetil caused fewer side effects such as dizziness，nausea and vomiting than tramadol.

Conclusion

Flurbiprofen axetil offered a useful alternative to tramadol with less side effects for the patient-controlled analgesia of postoperative pain.