目的

评价腹腔镜Nissen胃底折叠术（LNF）治疗胃食管反流病（GERD）的安全性。

方法

计算机检索MEDLINE、EMBASE、PubMed、CBM、CNKI及Cochrane图书馆；手工检索有关中文杂志。纳入LNF与传统开腹Nissen胃底折叠术（ONF）治疗GERD的前瞻性随机对照试验（RCT），用RevMan 4.2.2软件进行统计分析。

结果

共纳入6个RCT，包括442例患者，无一例术后死亡病例，Meta分析结果显示，LNF与ONF相比手术并发症发生率低，差异有统计学意义（P＜0.05）。

结论

与ONF相比LNF治疗GERD有更高的手术安全性，尚有待进一步开展大样本高质量的RCT予以证实。

Objective

To evaluate the safety of laparoscopic Nissen fundoplication (LNF)for gastroesophageal reflux disease(GERD).

Methods

The electronic databases(MEDLINE,EMBASE,PubMed,Cochrane Library, CBM, CNKI) were searched, and relevant chinese articles were also sought manually. The randomised controlled trails (RCTs)on LNF vs open nissen fundoplication (ONF)were identified.RevMan 4.2.2 software was used for statistical analysis.

Results

Six RCTs(which comprised 442 patients)on LNF vs ONF were included.No death was observed after the procedures in both groups.The result of Meta-analysis showed that there was statistical significant difference in incidence of complications between LNF and ONF (P＜0.05).

Conclusion

LNF is more safe than the open procedure for GERD.RCTs with large series and high quality are required to confirm this argument.