评价丙氨酰谷氨酰胺注射液（Ala-Gln）强化的胃肠外营养（TPN）对胃肠道肿瘤患者术后营养和免疫状况的影响。

137例胃肠道肿瘤患者术后被随机分为研究组66例和对照组71例，所有患者术后第1~7天给予TPN，等热量（104.5 kJ·kg^-1·d^-1）、等氮（0.2 g·kg^-1·d^-1），研究组另加入Ala-Gln注射液0.4 g·kg^-1·d^-1。分别于术前1 d及术后第4、8天观察血浆白蛋白（Alb）、前白蛋白（PAB）、转铁蛋白（TF），计算氮平衡变化，同时检测外周血IgA、IgG、IgM。

术后两组患者Alb、PAB、TF较术前均有不同程度下降，研究组恢复优于对照组，在术后第8天两组比较差异有统计学意义（P<0.05）。纠正负氮平衡研究组明显优于对照组，差异统计学意义（P<0.05）。研究组术后第8天IgA、IgG、IgM恢复较对照组差异具有统计学意义（P<0.05）。

加入Ala-Gln双肽加TPN可以改善胃肠道肿瘤患者术后营养，提高患者的免疫功能。

To evaluate the impact of total parenteral nutrition supplemented alanyl-glutamine on the postoperative nutrition and immunofunction of patients with gastrointestinal neoplasms.

One hundred and seventeen patients were randomly divided into study group(n=66) and control group(n=71). The patients in two groups receive isoenergetic(104.5 kJ·kg^-1·d^-1) and isonitrogenous (0.2 g·kg^-1·d^-1) TPN from postoperative first day to the seventh. Whereas the study group received additional 0.4g·kg^-1·d^-1 of Ala-Gln. Blood samples were collected on the morning of the first day before the operation and on the morning day 4 and day 8 after the operation and analyzed for immune and nutrition parameters. Nitrogen balance was calculated simultaneously.

Serum albumin, pre-albumin transferrin levels were both decreased in the two groups after surgery. The outcome of study group was better than that of the control group in day 8 after operation (P <0.05). Nitrogen balance in the Study group was better than the control group also(P <0.05). Compared with control group, the level of IgA, IgG, IgM in the Study group had increased in day 8 significantly (P <0.05).

Ala-Gln dipeptide in TPN is beneficial to postoperative patients of gastrointestinal neoplasms, and can improve patient's nutrition, enhance their immune function.