探讨术前血清血管内皮生长因子C（sVEGF-C）水平联合多排螺旋CT（MDCT）扫描能否作为判断结直肠癌淋巴结转移的理想方法。

ELISA方法测定110例结直肠癌患者（结直肠癌组）及40例健康者（对照组）的sVEGF-C浓度，MDCT平扫及三期强化动态扫描判断淋巴结有无转移。

结直肠癌组sVEGF-C浓度为（889.2±264.0）μg/L，对照组为（373.2±97.3）μg/L（P=0.000）；病理诊断伴有淋巴结转移的70例结直肠癌患者sVEGF-C明显升高[（996.2±247.1）μg/L vs（701.6±173.6）μg/L，P=0.000]；取临界点为996.2 μg/L时，sVEGF-C诊断淋巴结转移的敏感度为57.1%，特异度为85.0%，准确度为67.3%，阳性预测值为87.0%，阴性预测值为53.0%。MDCT诊断淋巴结转移的敏感度为51.4%，特异度为70.0%，准确度为58.2%，阳性预测值为75.0%，阴性预测值为45.2%。sVEGF-C联合MDCT诊断淋巴结转移的敏感度为75.7%，特异度为92.5%，准确度81.8%，阳性预测值94.6%，阴性预测值68.5%。

单独应用sVEGF-C或MDCT判断结直肠癌淋巴结转移效果均不理想，两者联合应用可进一步提高准确度，可作为术前判断淋巴结转移的有用指标。

To investigate whether serum vascular endothelial growth factor-C(sVEGF-C) and multidetector CT(MDCT) have relationships with lymph node metastasis(LNM) in colorectal cancer.

The sVEGF-C level of 110 patients and 40 donors were examined by ELISA.Both plain and enhanced MDCT scan of abdomen were performed.Detailed pathologic findings were recorded.

The level of sVEGF-C was higher in colorectal cancer group than in control group [(889.2±264.0)μg/L vs (373.2±97.3)μg/L]. As a cutoff value being 996.2μg/L, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of sVEGF-C for predicating LNM were 57.1%, 85.0%, 67.3%, 87.0%, 53.0%, respectively. MDCT were used to detect the LNM, the sensitivity, specificity, accuracy, positive, negative predictive value were 51.4%, 70.0%, 58.2%, 75.0%, 45.2%, respectively. When sVEGF-C associated with spiral CT were employed to diagnosis the LNM in colorectal cancer, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value was 75.7%, 92.5%, 81.8%, 94.6%, 68.5%, respectively.

sVEGF-C associated with MDCT can be used as a preoperative methode for diagnosis of LNM in colorectal cancer.