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中华普通外科学文献(电子版) ›› 2016, Vol. 10 ›› Issue (02) : 112 -115. doi: 10.3877/cma.j.issn.1674-0793.2016.02.006

所属专题: 文献

论著

胃癌横结肠系膜前叶及胰腺被膜转移规律的临床研究
龚龙波1,(), 吕孝鹏1, 孟良1, 谢志远1, 张才华1, 张文涛1   
  1. 1. 221009 东南大学医学院附属徐州医院胃肠外科
  • 收稿日期:2015-07-15 出版日期:2016-04-01
  • 通信作者: 龚龙波

Clinical research of metastasis rule in the pancreatic capsule and anterior layer of transverse me-socolon in gastric cancer

Longbo Gong1,(), Xiaopeng Lyu1, Liang Meng1, Zhiyuan Xie1, Caihua Zhang1, Wentao Zhang1   

  1. 1. Department of Gastrointestinal Surgery, Xuzhou Hospital, Medical College of Southeast Uni-versity, Xuzhou 221009, China
  • Received:2015-07-15 Published:2016-04-01
  • Corresponding author: Longbo Gong
  • About author:
    Corresponding author: Gong Longbo, Email:
引用本文:

龚龙波, 吕孝鹏, 孟良, 谢志远, 张才华, 张文涛. 胃癌横结肠系膜前叶及胰腺被膜转移规律的临床研究[J/OL]. 中华普通外科学文献(电子版), 2016, 10(02): 112-115.

Longbo Gong, Xiaopeng Lyu, Liang Meng, Zhiyuan Xie, Caihua Zhang, Wentao Zhang. Clinical research of metastasis rule in the pancreatic capsule and anterior layer of transverse me-socolon in gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(02): 112-115.

目的

探讨胃癌患者横结肠系膜前叶及胰腺被膜的转移规律及其对临床的指导意义。

方法

收集2012年6月至2014年1月东南大学医学院附属徐州医院胃肠外科收治的80例胃癌患者手术标本,免疫组织化学染色及病理学检查判断横结肠系膜前叶及胰腺被膜是否存在癌转移,分析其与胃癌临床病理特征的关系。

结果

17例患者横结肠系膜前叶和(或)胰腺被膜免疫组织化学染色检测示癌转移,其中5例同时经病理检查也提示癌转移。胃癌横结肠系膜前叶及胰腺被膜癌转移与肿瘤浸润深度、肿瘤部位、淋巴结转移及TNM分期有关(P<0.05),而与患者的年龄、性别、肿瘤组织分化程度无关。

结论

胃癌根治术中应选择性地切除横结肠系膜前叶及胰腺被膜,对肿瘤侵及浆膜层及TNM分期为Ⅲ期的胃癌患者应彻底切除横结肠系膜前叶及胰腺被膜,对肿瘤未侵及浆膜层及TNM分期为Ⅰ、Ⅱ期的胃癌患者可不切除横结肠系膜前叶及胰腺被膜。

Objective

To investigate the metastasis rule and its clinical significance in the pan-creatic capsule and anterior layer of transverse mesocolon in gastric cancer.

Methods

A total of eighty specimens in gastric cancer were collected from June 2012 to January 2014 in the Department of Gastroin-testinal Surgery, Xuzhou Hospital, Medical College of Southeast University. The pancreatic capsule and anterior layer of transverse mesocolon were histologically and immunohistochemically analyzed for metas-tasis, and to analyze its relationship with clinicopathologic characteristics in gastric cancer.

Results

Metastasis to anterior layer of transverse mesocolon and/or pancreatic capsule happened in 17 patients by immunohistochemistry and 5 patients were detected histologically in the same time. The metastases to the anterior layer of transverse mesocolon and/or pancreatic capsule were found to be associated with tumor in-vasion depth, tumor location, lymph node metastasis extent and clinical TNM staging (P<0.05), but not with age, gender and pathological classification.

Conclusions

The anterior layer of transverse mesocolon and pancreatic capsule should be selectively dissected in the surgery of distal gastric cancer. If the depth of tumor invasion extends beyond the serosa and in TNM staging Ⅲ, it is necessary to remove the anterior layer of transverse mesocolon and pancreatic capsule, otherwise there is no necessity.

图1 免疫组化分析CK19蛋白在胃癌患者横结肠系膜前叶及(或)胰腺被膜中的表达(SP×400)
表1 胃癌横结肠系膜前叶及(或)胰腺被膜转移与其临床病理特征的关系
1
Saika K,Sobue T. Cancer statistics in the world[J]. Gan To Kaqa-ku Ryoho, 2013, 40(13): 2475-2480.
2
Shen L,Shan YS,Hu HM, et al. Management of gastric cancer in Asia: resource-stratified guidelines[J]. Lancet Oncoll, 2013, 14(12): e535-547.
3
Viudez-Berral A,Miranda-Murua C,Arias-de-la-Vega F, et al. Current management of gastric cancer[J]. Rev Esp Enferm Dig, 2012, 104(3): 134-141.
4
Allum WH. Optimal surgery for gastric cancer: is more always better?[J]. Recent Results Cancer Res, 2012, 196: 215-227.
5
Skoropad VIu,Berdov BA. The influence of lymphadenectomy on the results of the gastric cancer treatment[J]. Khirurgiia (Mosk), 2013, 32(1): 25-33.
6
Isozaki H,Okajima K,Fujii K. Histological evaluation of lymph node metastasis on serial sectioning in gastric cancer with radical lymphadenectomy[J]. Hepatogastroenterology, 1997, 44(16): 1133-1136.
7
季加孚,陕飞.胃癌根治术规范化[J/CD].中华普外科手术学杂志:电子版, 2010, 4(2): 114-118.
8
Saka M,Morita S,Fukagawa T, et al. Present and future status of gastric cancer surgery[J]. Jpn J Clin Oncol, 2011, 41(3): 307-313.
9
Imamura H,Kurokawa Y,Kawada J, et al. Influence of bursecto-my on operative morbidity and mortality after radical gastrectomy for gastric cancer: results of a randomized controlled trial[J]. World J Surg, 2011, 35(3): 625-630.
10
Fujita J,Kurokawa Y,Sugimoto T, et al. Survival benefit of bur-sectomy in patients with resectable gastric cancer: interim analy-sis results of a randomized controlled trial[J]. Gastric Cancer, 2012, 15(1): 42-48.
11
日本胃癌学会.胃癌治疗ガイドライン(第3版)[M].金原出版株式会社, 2010.
12
马沛.比较腹腔镜下胃癌根治术与开腹胃癌根治术治疗早期胃癌患者的预后与生存率[J/CD].中华临床医师杂志:电子版, 2014, 8(2): 350-352.
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