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中华普通外科学文献(电子版) ›› 2016, Vol. 10 ›› Issue (02) : 158 -162. doi: 10.3877/cma.j.issn.1674-0793.2016.02.018

所属专题: 文献

综述

吉西他滨为基础的一线联合疗法治疗胰腺癌研究进展
崔啸晨1, 马志亮1, 王志茹1,()   
  1. 1. 030000 太原,山西医科大学第二医院普外科
  • 收稿日期:2015-07-01 出版日期:2016-04-01
  • 通信作者: 王志茹
  • 基金资助:
    山西省留学人员重点科研资助项目(2010-099)

Development of the gemcitabine-based first-line therapies for pancreatic cancer

Xiaochen Cui1, Zhiliang Ma1, Zhiru Wang1,()   

  1. 1. Department of General Surgery, the Second Hospital of Shanxi Medical Universi-ty, Taiyuan 030001, China
  • Received:2015-07-01 Published:2016-04-01
  • Corresponding author: Zhiru Wang
  • About author:
    Corresponding author: Wang Zhiru, Email:
引用本文:

崔啸晨, 马志亮, 王志茹. 吉西他滨为基础的一线联合疗法治疗胰腺癌研究进展[J]. 中华普通外科学文献(电子版), 2016, 10(02): 158-162.

Xiaochen Cui, Zhiliang Ma, Zhiru Wang. Development of the gemcitabine-based first-line therapies for pancreatic cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(02): 158-162.

胰腺癌早期临床症状不明显,晚期易于发生肝脏等其他组织器官的远处转移,所以预后极差,5年生存率徘徊在4%~6%。手术切除是目前唯一有可能治愈的方式,但大多数患者直到疾病晚期才被发现,已失去了手术机会,手术切除率不足20%。术后并发症及肿瘤的复发使患者的生存状况无显著改观。目前,吉西他滨作为治疗胰腺癌的最佳基础用药,是美国食品药品管理局FDA批准的治疗胰腺癌的一线化疗药物,可以显著延长患者的生存时间。吉西他滨联合其他抗肿瘤药物不仅使其抑癌作用增强,还减少了某些不良反应及耐药性的发生。最新NCCN指南也推荐吉西他滨+白蛋白结合的紫杉醇、吉西他滨+厄洛替尼、吉西他滨+卡培他滨等为治疗胰腺癌一线联合治疗方案。该文通过复习相关文献报道,对以吉西他滨为基础的几种一线联合化疗方案的最新临床研究进展作一综述,以期开阔思路,寻找更好的治疗、研究方案。

Pancreatic cancer is characterized by its insidious onset, which is easy to be present with liver metastasis or other distant organ metastasis at advanced stage, so the prognosis is extremely poor with 5-year survival rate being 4%-6%. Radical resection may be the only curative treatment. How-ever, most patients have lost the chance for surgical resection because of late diagnosis, and the resection rate is less than 20%. What's more, postoperative complications and recurrence make influence on pa-tients' quality of life without significant improvement. For now gemcitabine acting as the gold standard chemotherapy for the treatment of pancreatic cancer, approved by FDA as the first-line chemotherapy drug, can significantly prolong patients' lifetime. Gemcitabine combined with other drugs not only increase the anti-tumor effect, but also decrease the frequency of adverse events and drug resistance. Combination therapy such as gemcitabine+nab-paclitaxel, gemcitabine+erlotinib, gemcitabine+capecitabine have be recommended as the first-line therapy for the treatment of pancreatic cancer by the latest NCCN Guide-lines. This article reviews the most current articles, looking for developments about the gemcitabine-based first-line therapies in order to find better treatment and research strategy of pancreatic cancer.

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