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中华普通外科学文献(电子版) ›› 2016, Vol. 10 ›› Issue (03) : 227 -230. doi: 10.3877/cma.j.issn.1674-0793.2016.03.017

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综述

分子靶向药物索拉非尼在甲状腺癌的应用进展
孙海清1, 姜立新1, 李宝元1, 郑海涛1,()   
  1. 1. 264000 烟台毓璜顶医院胃肠外一、甲状腺外科
  • 收稿日期:2015-08-15 出版日期:2016-06-01
  • 通信作者: 郑海涛

Application development of the molecular targeted therapy sorafenib for thyroid carcinoma

Haiqing Sun1, Lixin Jiang1, Baoyuan Li1, Haitao Zheng1,()   

  1. 1. Department of Gastrointestinal and Thyroid Surgery, Yantai Yuhuangding Hospital, Yantai 264000, China
  • Received:2015-08-15 Published:2016-06-01
  • Corresponding author: Haitao Zheng
  • About author:
    Corresponding author: Zheng Haitao, Email:
引用本文:

孙海清, 姜立新, 李宝元, 郑海涛. 分子靶向药物索拉非尼在甲状腺癌的应用进展[J/OL]. 中华普通外科学文献(电子版), 2016, 10(03): 227-230.

Haiqing Sun, Lixin Jiang, Baoyuan Li, Haitao Zheng. Application development of the molecular targeted therapy sorafenib for thyroid carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(03): 227-230.

部分难治性甲状腺癌和特殊病理类型的甲状腺癌缺少有效的治疗方法,预后较差。国内外多个医疗中心已进行过索拉非尼治疗甲状腺癌的临床研究,多数已进入2、3期临床试验,包括晚期分化型甲状腺癌、髓样癌、未分化癌等,临床试验证实索拉非尼可有效提高甲状腺癌患者无进展生存期(PFS)、客观缓解率(OR),但对总生存期(OS)的影响尚无定论。本文将围绕索拉非尼的作用机制、治疗效果及不良反应,讨论索拉非尼用于治疗甲状腺癌的进展。

Part of radioactive iodine-refractory and special pathological types of thyroid cancer lacks effective treatment, leading to poor outcomes. Clinical studies of sorafenib treatment for thyroid cancer have been subjected to many domestic and international medical centers, most of which have entered the phase 2 and 3 clinical trials, including advanced differentiated thyroid cancer, medullary carcinoma, and anaplastic carcinoma. In some clinical trials, sorafenib has improved median progression-free survival (PFS), objective response (OR) rate, but the impact on overall survival (OS) is inconclusive. This article will focus on the mechanisms of sorafenib, treatment and adverse reactions, to discuss the progression of sorafenib for the treatment of thyroid cancer.

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