切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2017, Vol. 11 ›› Issue (01) : 41 -43. doi: 10.3877/cma.j.issn.1674-0793.2017.01.010

所属专题: 文献

论著

预防性右侧喉返神经深层淋巴清扫术在右侧甲状腺乳头状非微小癌术中的必要性探讨
龙淼云1, 梁思华1, 谭浪平1, 朱玥1, 黄明清1, 罗定远1, 黄楷1, 黎洪浩1,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院甲状腺外科
  • 收稿日期:2016-04-01 出版日期:2017-02-01
  • 通信作者: 黎洪浩

Prophylactic dissection of lymph node posterior to right recurrent laryngeal nerve of non-minimal papillary thyroid carcinoma in the right lobe

Miaoyun Long1, Sihua Liang1, Langping Tan1, Yue Zhu1, Mingqing Huang1, Dingyuan Luo1, Kai Huang1, Honghao Li1,()   

  1. 1. Department of Thyroid Surgery, Sun Yat-sen Memorial Hospital, Guangzhou 510120, China
  • Received:2016-04-01 Published:2017-02-01
  • Corresponding author: Honghao Li
  • About author:
    Corresponding author: Li Honghao, Email:
引用本文:

龙淼云, 梁思华, 谭浪平, 朱玥, 黄明清, 罗定远, 黄楷, 黎洪浩. 预防性右侧喉返神经深层淋巴清扫术在右侧甲状腺乳头状非微小癌术中的必要性探讨[J]. 中华普通外科学文献(电子版), 2017, 11(01): 41-43.

Miaoyun Long, Sihua Liang, Langping Tan, Yue Zhu, Mingqing Huang, Dingyuan Luo, Kai Huang, Honghao Li. Prophylactic dissection of lymph node posterior to right recurrent laryngeal nerve of non-minimal papillary thyroid carcinoma in the right lobe[J]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(01): 41-43.

目的

探讨预防性右侧喉返神经深层淋巴(LN-prRLN)清扫术在右侧甲状腺乳头状非微小癌术中的意义。

方法

回顾性分析中山大学孙逸仙纪念医院甲状腺外科2013年1月至2014年12月395例右侧甲状腺乳头状非微小癌行中央区淋巴结(CCLN)清扫术的患者资料,根据术中是否行清扫术分为清扫组和未清扫组,其中清扫组205例,非清扫组190例。统计两组患者CCLN及LN-prRLN的转移情况。

结果

清扫组发生CCLN转移53.17%,非清扫组51.58%,差异无统计学意义(χ2=3.34,P=0.345)。清扫组LN-prRLN转移率为14.15%,低于中央区其他部位淋巴转移率(53.17%),差异有统计学意义(χ2=0.57,P=0.001)。清扫组患者的平均中央区阳性淋巴结为(6.7±1.4)个,而非清扫组为(5.2±1.4)个,差异有统计学意义(t=0.38,P=0.036)。两组患者均未出现永久性声嘶或永久性甲状旁腺功能低下。清扫组和非清扫组各有5例患者出现暂时性声嘶,差异无统计学意义(2.44% vs 2.63%,χ2=0.01,P=0.939);暂时性甲状旁腺功能低下发生率分别为17.07%(35/205)和9.47%(18/190),差异有统计学意义(χ2=0.42,P=0.027)。

结论

LN-prRLN是右侧甲状腺乳头状非微小癌的淋巴转移好发位置之一,预防性行LN-prRLN清扫术增加了CCLN的阳性检出率,并可使分期更为准确。

Objective

To investigate the role of prophylactic dissection of lymph node posterior to right recurrent laryngeal nerve (LN-prRLN) of non-minimal papillary carcinoma in the right lobe of thyroid gland.

Methods

A retrospective analysis of three hundred and ninety-five patients was conducted of non-minimal papillary thyroid carcinoma in the right lobe from January 2013 to December 2014 of Sun Yat-sen Memorial Hospital. The patients were divided into prophylactic dissection group (205 cases) and non-prophylactic dissection group (190 cases). Central compartment lymph node (CCLN) metastasis and LN-prRLN was analyzed in the two groups.

Results

CCLN metastasis was found in 53.17% of prophylactic dissection group, and in 51.58% of non-prophylactic dissection group, with no significant difference (χ2=3.34, P=0.345). In prophylactic dissection group, 14.15% of LN-prRLN was found invasive, which was lower than other parts of central compartment lymph node district (53.17%, χ2=0.57, P=0.001). Averagely, (6.7±1.4) CCLNs were found in prophylactic dissection group, whereas (5.2±1.4) in non-prophylactic dissection group, which was significantly different (t=0.38, P=0.036). Neither permanent hoarse nor hypoparathyroidism was found in the two groups, but each group had 5 cases of transient hoarse with no statistically significant differences. Transient hypoparathyroidism was 17.07% (35/205) and 9.47% (18/190) in prophylactic dissection group and non-prophylactic dissection group, which had significant difference (χ2=0.42, P=0.027).

Conclusion

LN-prRLN metastasis of non-minimal papillary carcinoma is not uncommon, while prophylactic dissection of LN-prRLN can increase detected positive metastatic rate of CCLN.

[1]
White ML,Gauger PG,Doherty GM. Central lymph node dissectionin differentiated thyroid cancer[J]. World J Surg, 2007, 31(5): 895-904.
[2]
吴干勋,胡俊兰,赵瑞力, 等. 纳米碳在甲状腺癌行甲状腺全切加双侧中央区清扫中的作用[J]. 中华医学杂志, 2015, 95(12): 912-917.
[3]
Cooper DS,Doherty GM,Haugen BR, et a1. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J]. Thyroid,2009, 19(11): 1167-1214.
[4]
Roy B,Terry T,Carrie A. Cancer of the thyroid gland[M]∥Louis B,Waun KH.Head and neck cancer: a multidisciplinary approach.Philadelphia: Lippincott Raven, 1998: 807-808.
[5]
Bae SY,Yang JH,Choi MY, et al. Right paraesophageal lymphnode dissection in papillary thyroid carcinoma[J]. Ann Surg Oncol, 2012, 19(3): 996-1000.
[6]
Montero PH,Ibrahimpasic T,Nixon IJ, et al. Thyroid metastasectomy[J]. J Surg Oncol, 2014, 109(1): 36-41.
[7]
Kim YS,Park WC. Clinical predictors of right upper paraesophageal lymph node metastasis from papillary thyroid carcinoma[J]. World J Surg Oncol,2012,10: 164.
[8]
Zhang L,Wei WJ,Ji QH, et al. Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma:a study of 1 066 patients[J]. J Clin Endocrinol Metab,2012,97(4): 1250-1257.
[9]
黄辉,徐震纲,王晓蕾, 等. 淋巴结临床阴性甲状腺乳头状癌中央区淋巴结清扫后颈部复发模式分析[J]. 中华肿瘤杂志, 2015, 37(10): 771-775.
[1] 邵华, 那子悦, 荆慧, 李博, 王秋程, 程文. 术前经皮超声造影对乳腺癌腋窝前哨淋巴结转移及负荷的诊断价值[J]. 中华医学超声杂志(电子版), 2023, 20(08): 849-853.
[2] 孙帼, 谢迎东, 徐超丽, 杨斌. 超声联合临床特征的列线图模型预测甲状腺乳头状癌淋巴结转移的价值[J]. 中华医学超声杂志(电子版), 2023, 20(07): 734-742.
[3] 李雄雄, 周灿, 徐婷, 任予, 尚进. 初诊导管原位癌伴微浸润腋窝淋巴结转移率的Meta分析[J]. 中华普通外科学文献(电子版), 2023, 17(06): 466-474.
[4] 燕速, 霍博文, 徐惠宁. 4K荧光腹腔镜扩大右半结肠CME+D3根治术及No.206、No.204组淋巴结清扫术[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 14-14.
[5] 杜晓辉, 崔建新. 腹腔镜右半结肠癌D3根治术淋巴结清扫范围与策略[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 5-8.
[6] 杨体飞, 杨传虎, 陆振如. 改良无充气经腋窝入路全腔镜下甲状腺手术对喉返神经功能的影响研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 74-77.
[7] 黄崇植, 肖映胜, 杨熙鸿, 林炘. 甲状腺下动脉的上行分支在甲状腺术中定位喉返神经的应用研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 607-610.
[8] 袁育韬, 邢金琳, 谢克飞, 殷凯. CT征象及BRAFV600E基因突变与甲状腺乳头状癌中央区淋巴结转移的相关性[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 611-614.
[9] 崔占斌, 乔军利, 张丽丽, 韩明强. 尿碘水平与甲状腺乳头状癌患者术后复发危险度分层的相关性[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 615-618.
[10] 陈垚, 徐伯群, 高志慧. 改良式中间上入路根治术治疗甲状腺癌的有效性安全性研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 619-622.
[11] 江振剑, 蒋明, 黄大莉. TK1、Ki67蛋白在分化型甲状腺癌组织中的表达及预后价值研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 623-626.
[12] 黄汇, 朱信强. 131I治疗45岁以下分化型甲状腺癌的疗效及影响因素[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 627-630.
[13] 樊丽超, 郭瑾瑛, 陈鑫. 野生型RET与RET/PTC融合基因检测对甲状腺乳头状癌中央区淋巴结清扫的指导意义[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 631-635.
[14] 徐成, 王璐璐, 王少华. 洗脱液甲状腺球蛋白在甲状腺乳头状癌转移淋巴结中的应用[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 701-704.
[15] 潘冰, 吕少诚, 赵昕, 李立新, 郎韧, 贺强. 淋巴结清扫数目对远端胆管癌胰十二指肠切除手术疗效的影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 608-612.
阅读次数
全文


摘要