探讨新型纳米仿生补片在腹壁疝修补治疗中应用的可行性。

选择新西兰大白兔25只，通过建立兔腹壁肌肉缺损区的疝模型，术后1周观察动物腹壁突出情况。采用一期修补的方式，使用新型纳米仿生补片无张力修补腹壁疝，观察术后切口感染、疝复发等并发症。取出包括网片在内的腹壁全层，做组织学观察和免疫组化研究。

未发现手术及麻醉并发症，也未发现补片感染的案例，所有修补模型未发现复发。新型纳米补片几乎不引起腹腔粘连，术后6个月内新型纳米仿生补片变性吸收，胶原纤维增生，被结缔组织所替代，逐渐形成一致密结缔组织层。

我们可以通过切除腹壁2 cm×3 cm全层腹壁组织结构获得稳定的动物疝模型，此新型纳米仿生补片可能是一种较为理想的腹外疝修补材料。

To determine whether the host tissue responses in the abdominal hernia rabbit model and explore the feasibility of repairing the hernia with biotic mesh.

To establish the model of incisional hernia, full structure of abdominal wall (muscle and peritoneum) of rabbits was cut by size of 2 cm×3 cm. Protruding abdominal mass of rabbits was observed one week later. The incisional hernias were repaired with nanometer bionic mesh in the one-stage operation. The complications, including infection of incisional wound and recurrence of hernia, were observed. Full-thickness sections of abdominal wall were evaluated by histological and immunohistochemical analysis.

No intraoperative or anesthesia-related complications or mesh infection were recorded. We were able to establish the model of incisional hernia one week postoperatively and typically. No recurrent hernia was found in one stage repair. There were few intraperitoneal adhesions induced by the nanometer bionic mesh. The nanometer bionic mesh became changed and absorbed subsequently with collagen proliferation and turned to be dense connective tissue at 6 months after operation.

Removal of abdominal tissues by size of 2 cm×3 cm can build a stable model of incisional hernia. The nanometer bionic mesh may be an ideal mesh for repairing abdominal external hernia.