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中华普通外科学文献(电子版) ›› 2017, Vol. 11 ›› Issue (02) : 89 -92. doi: 10.3877/cma.j.issn.1674-0793.2017.02.005

所属专题: 文献

论著

支链氨基酸转氨酶1高表达预测结直肠癌预后不佳的研究
郭雄图1, 陈显国1, 胡玉萍1, 李天翔1, 袁南贵1, 陈元岩1,()   
  1. 1. 510800 广州市中西医结合医院外儿科
  • 收稿日期:2016-06-30 出版日期:2017-04-01
  • 通信作者: 陈元岩

Prognosis prediction of colorectal cancer by high expression of branched chain amino acid aminotransferase 1

Xiongtu Guo1, Xianguo Chen1, Yuping Hu1, Tianxiang Li1, Nangui Yuan1, Yuanyan Chen1,()   

  1. 1. Department of General Surgery, Guangzhou Hospital of Integrated Chinese and Western Medicine, Guangzhou 510800, China
  • Received:2016-06-30 Published:2017-04-01
  • Corresponding author: Yuanyan Chen
  • About author:
    Corresponding author: Chen Yuanyan, Email:
引用本文:

郭雄图, 陈显国, 胡玉萍, 李天翔, 袁南贵, 陈元岩. 支链氨基酸转氨酶1高表达预测结直肠癌预后不佳的研究[J/OL]. 中华普通外科学文献(电子版), 2017, 11(02): 89-92.

Xiongtu Guo, Xianguo Chen, Yuping Hu, Tianxiang Li, Nangui Yuan, Yuanyan Chen. Prognosis prediction of colorectal cancer by high expression of branched chain amino acid aminotransferase 1[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(02): 89-92.

目的

探讨支链氨基酸转氨酶1(BCAT1)蛋白高表达与结直肠癌临床病理特征和生存预后的关系。

方法

回顾性分析2007年1月至2013年5月收治72例结直肠癌患者的临床病理资料,采用免疫组织化学的方法分析比较20例癌旁正常结肠黏膜组织和72例结直肠癌组织中BCAT1蛋白的表达水平,进一步分析结直肠癌组织中BCAT1高表达与患者临床病理特征及总体生存预后的关系。

结果

结直肠癌组织中BCAT1蛋白表达阳性率为65.3%(47/72),显著高于癌旁正常结肠组织(30.0%),差异具有统计学意义(χ2=7.976,P=0.005)。位于直肠、T分期、淋巴结转移、TNM Ⅲ+Ⅳ分期的组织中有较高的BCAT1蛋白阳性表达率(分别χ2=5.296、4.541、11.387、5.091,均P<0.05)。生存分析结果显示BCAT1阴性的结直肠癌患者术后总体预后明显优于BCAT1阳性者,5年生存率分别为52.8%和15.1%(χ2=9.242,P=0.002)。

结论

BCAT1蛋白表达检测阳性提示结直肠癌患者的临床病理特点不佳,预示总体生存预后不良,是结直肠癌诊断和预后标记物方面的潜在生物学靶点。

Objective

To study the relationship between the high expression of branched chain amino-acid transaminase 1 (BCAT1) and clinicopatholotical features as well as survival outcome for colorectal cancer.

Methods

A retrospective analysis of seventy two eligible patients diagnosed as coloretal cancer between January 2007 and May 2013 was performed. The incidence of positive BCAT1 staining in adjacent normal tissues (n=20) and colorecal cancer tissues (n=72) were analyzed by immunohistochemical method. The relationship between the high expression of BCAT1 in colorectal carcinoma and the clinicopathological characteristics and the prognosis was further conducted.

Results

The positive expression rate of BCAT1 protein in colorectal cancer tissues was 65.3% (47/72), significantly higher than that in adjacent normal colonic tissues (30.0%); the difference was statistically significant (χ2=7.976, P=0.005). The positive expression of BCAT1 protein was higher in tissues with rectum, T staging, lymph node metastasis, and TNM III+IV stage (χ2=5.296, 4.541, 11.387, 5.091, respectively, all P<0.05). Prognosis analysis showed that the overall survival of colorectal cancer patients with negative expression of BCAT1 was significantly better than those with positive expression of BCAT1, and 5-year survival rate was 52.8% and 15.1%, respectively (χ2=9.242, P=0.002).

Conclusions

Positive expression of BCAT1 protein prompts to poor pathological characteristics and prognosis for colorectal cancer patients. BCAT1 is a potential biological target for diagnosis and prognosis judgement of colorectal cancer.

图1 免疫组织化学染色检测BCAT1在癌旁正常组织及结直肠癌组织中的表达(SP法×200) A为癌旁正常组织BCAT1阴性;B为癌旁正常组织BCAT1阳性;C为结肠癌组织BCAT1阴性;D为结肠癌组织BCAT1阳性
表1 BCAT1蛋白表达与结直肠癌临床病理特征之间的关系
图2 结直肠癌组织中BCAT1不同表达的生存曲线比较
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