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中华普通外科学文献(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 28 -31. doi: 10.3877/cma.j.issn.1674-0793.2018.01.007

所属专题: 文献

论著

乳腺癌淋巴管侵犯与淋巴结转移率的相关性研究
姚家炳1, 贾琳娇1, 司丕蕾1, 黄毅2, 方斌1, 陈海军1, 李文涛1,()   
  1. 1. 450003 郑州大学人民医院(河南省人民医院)乳腺外科
    2. 401220 重庆市长寿区人民医院普外科
  • 收稿日期:2017-08-01 出版日期:2018-02-01
  • 通信作者: 李文涛
  • 基金资助:
    河南省医学科技攻关计划省部共建项目(201601013)

Study on the correlation between lymphovascular invasion and lymph node ratio in patients withbreast cancer

Jiabing Yao1, Linjiao Jia1, Pilei Si1, Yi Huang2, Bin Fang1, Haijun Chen1, Wentao Li1,()   

  1. 1. Department of Breast Surgery, Henan Provincial People’s Hospital, Peopie’s Hospital of Zhengzhou University, Zhengzhou 450003, China
    2. Department of General Surgery, Changshou District of Chongqing People's Hospital, Chongqing 401220, China
  • Received:2017-08-01 Published:2018-02-01
  • Corresponding author: Wentao Li
  • About author:
    Corresponding author: Li Wentao, Email:
引用本文:

姚家炳, 贾琳娇, 司丕蕾, 黄毅, 方斌, 陈海军, 李文涛. 乳腺癌淋巴管侵犯与淋巴结转移率的相关性研究[J/OL]. 中华普通外科学文献(电子版), 2018, 12(01): 28-31.

Jiabing Yao, Linjiao Jia, Pilei Si, Yi Huang, Bin Fang, Haijun Chen, Wentao Li. Study on the correlation between lymphovascular invasion and lymph node ratio in patients withbreast cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2018, 12(01): 28-31.

目的

探讨乳腺癌组织中淋巴管侵犯(LVI)与淋巴结转移率(LNR)的关系。

方法

采用免疫组织化学法,用单克隆抗体D2-40及CK pan检测118例乳腺癌患者蜡块组织标本的LVI阳性率。

结果

118例乳腺癌组织的LVI阳性率为37.3%(42/118);LVI阳性率与LNR、淋巴结转移数目、组织学分级呈正相关(χ2= 9.186、6.996、18.340,P=0.010、0.030、0.000)。

结论

LVI可作为判断乳腺癌发生腋窝淋巴结转移的重要参考指标,且LNR越高,LVI发生率越高。

Objective

To investigate the relationship between lymphovascular invasion (LVI) and lymph node ratio (LNR) in breast cancer.

Methods

The positive rate of LVI in one hundred and eighteen breast cancer patients was detected by immunohistochemical staining with monoclonal antibody D2-40 grade CK pan immunohistochemical staining to analyze the relationship between LVI and LNR.

Results

The positive rate of LVI was 37.3% (42/118), significantly related to lymph node ration, the number of lymphatic metastasis and histological grade ( χ2=9.186, 6.996, 18.340, P=0.010, 0.030, 0.000).

Conclusion

Lymphovascular invasion can be used as an important reference index for the diagnosis of axillary lymph node metastasis of breast cancer, and the higher the lymph node ratio, the higher the incidence of lymphatic invasion.

表1 118例乳腺癌患者的临床病理资料与LVI的关系
图1 免疫组织化学染色观察乳腺癌组织周围淋巴管的形态变化及LVI(光学显微镜下,×100)红色箭头为癌组织周围淋巴管的形态,蓝色为癌栓
图2 免疫组织化学染色观察乳腺癌组织中淋巴管的形态变化(光学显微镜下,×100)
图3 免疫组织化学染色观察乳腺癌组织中LVI(光学显微镜下,×100)
[3]
Tausch C, Taucher S, Dubsky P, et al. Prognostic value of number of removed lymph nodes, number of involved lymph nodes, and lymph node ratio in 7 502 breast cancer patients enrolled onto trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)[J]. Ann Surg Oncol, 2012, 19(6): 1808-1817.
[4]
Duraker N, Bati B, ZCÇ, et al. Lymph node ratio may be supplementary to TNM nodal classification in node-positive breast carcinoma based on the results of 2 151 patients[J]. World J Surg, 2013, 37(6): 1241-1248.
[5]
Vinh-Hung V, Nguyen NP, Cserni G, et al. Prognostic value of nodal ratios in node-positive breast cancer: a compiled update[J]. Future Oncol, 2009, 5(10): 1585-1603.
[6]
Yang YS, Wang WP, Chen LQ. The effect of interaction between lymphovascular invasion and lymph node metastasis[J]. Surgery, 2017, 161(5): 1466-1467.
[7]
Zhang S, Zhang D, Yi S, et al. The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis[J]. Oncotarget, 2017, 8(2): 2863-2873.
[8]
Van der Auwera I, Cao Y, Tille JC, et al. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours[J]. Br J Cancer, 2006, 95(12): 1611-1625.
[9]
Rose AE, Christos PJ, Dan L, et al. Clinical relevance of detection of lymphovascular invasion in primary melanoma using endothelial markers D2-40 and CD34[J]. Am J Surg Pathol, 2012, 35(10): 1441-1449.
[10]
Zhou ZY, Sun RC, Yang GY, et al. Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma?[J]. Int J Surg Pathol, 2010, 18(5): 363-368.
[11]
杨翠翠,刘芳芳,李帅, 等. 淋巴结转移数和淋巴结转移率与乳腺癌预后关系的分析比较[J]. 中国肿瘤临床, 2012, 39(10): 692-697.
[12]
Karlsson P, Cole BF, Price KN, et al. The role of the number of uninvolved lymph nodes in predicting locoregional recurrence in breast cancer[J]. J Clin Oncol, 2007, 25(15): 2019-2026.
[13]
杨宏伟,田茂新,罗启志, 等. 乳腺癌癌周淋巴管密度对腋淋巴结转移状态的影响[J/CD]. 中华普通外科学文献(电子版), 2011, 5(3): 203-205.
[14]
Dadras SS, Lange-Asschenfeldt B, Velasco P, et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes[J]. Mod Pathol, 2005, 18(9): 1232-1242.
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宋宛芝,高晋南,杨海波. 乳腺癌的流行状况及发病特征[J]. 中国药物与临床, 2017, 17(2): 228-229.
[2]
Dings PJ, Elferink MA, Strobbe LJ, et al. The prognostic value of lymph node ratio in node-positive breast cancer: a Dutch nationwide population-based study[J]. Ann Surg Oncol, 2013, 20(8): 2607-2614.
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