切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 135 -138. doi: 10.3877/cma.j.issn.1674-0793.2018.02.017

所属专题: 文献

综述

肝外胆管癌术后辅助放化疗治疗进展
杜奉舟1, 张宁1, 何小东1, 左宇志1, 徐源1, 曲强1,()   
  1. 1. 100730 北京,中国医学科学院 北京协和医学院北京协和医院基本外科
  • 收稿日期:2017-11-29 出版日期:2018-04-01
  • 通信作者: 曲强
  • 基金资助:
    国家临床重点专科建设项目(2017)

Progress in postoperative adjuvant chemoradiotherapy for extrahepatic cholangiocarcinoma

Fengzhou Du1, Ning Zhang1, Xiaodong He1, Yuzhi Zuo1, Yuan Xu1, Qiang Qu1,()   

  1. 1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
  • Received:2017-11-29 Published:2018-04-01
  • Corresponding author: Qiang Qu
  • About author:
    Corresponding author: Qu Qiang, Email:
引用本文:

杜奉舟, 张宁, 何小东, 左宇志, 徐源, 曲强. 肝外胆管癌术后辅助放化疗治疗进展[J/OL]. 中华普通外科学文献(电子版), 2018, 12(02): 135-138.

Fengzhou Du, Ning Zhang, Xiaodong He, Yuzhi Zuo, Yuan Xu, Qiang Qu. Progress in postoperative adjuvant chemoradiotherapy for extrahepatic cholangiocarcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2018, 12(02): 135-138.

肝外胆管癌(ECC)是一种恶性程度较高的肿瘤,即使在病变早期进行根治性切除手术,患者术后仍有较高的复发率,总体生存率低。近几年来,ECC术后辅助治疗的研究逐渐开展,以吉西他滨、氟尿嘧啶等为基础的辅助化疗或联合放、化疗可使ECC患者术后获益,延长患者的总生存期。然而现有的辅助治疗方案各异,缺少ECC术后辅助治疗的标准方案。本文结合最新发表的研究结果,讨论ECC术后辅助治疗的现状和主要措施。

Extrahepatic cholangiocarcinoma (ECC) is highly malignant. Even radical resection is performed in the early stage, ECC patients still have a high recurrence rate, with low overall survival. In recent years, clinical trials of postoperative adjuvant therapy have been carried out gradually. Adjuvant chemotherapy or combined chemoradiotherapy based on gemcitabine and fluorouracil have been shown beneficial for ECC patients after resection, prolonging the total survival of patients. However, the existing adjuvant therapy protocols are different, and there is no standard adjuvant therapy to recommend. This review discusses the status and main measures of postoperative adjuvant therapy for ECC, combined with the latest published findings.

[1]
Jung SJ, Woo SM, Park HK, et al. Patterns of initial disease recurrence after resection of biliary tract cancer[J]. Oncology, 2012, 83(2): 83-90.
[2]
陶连元,何小东,高飞, 等. 肝外胆管癌的临床病理与预后分析[J]. 肝胆外科杂志, 2011, 19(4): 251-253.
[3]
Takada T, Amano H, Yasuda H, et al. Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase Ⅲ multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma[J]. Cancer, 2002, 95(8): 1685-1695.
[4]
Neoptolemos JP, Moore MJ, Cox TF, et al. Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial[J]. JAMA, 2012, 308(2): 147-156.
[5]
Horgan AM, Amir E, Walter T, et al. Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis[J]. J Clin Oncol, 2012, 30(16): 1934-1940.
[6]
Hoehn RS, Wima K, Ertel AE, et al. Adjuvant chemotherapy and radiation therapy is associated with improved survival for patients with extrahepatic cholangiocarcinoma[J]. Ann Surg Oncol, 2015, 22 Suppl 3: S1133-S1139.
[7]
McNamara MG, Walter T, Horgan AM, et al. Outcome of adjuvant therapy in biliary tract cancers[J]. Am J Clin Oncol, 2015, 38(4): 382-387.
[8]
Yang H, Zhou J, Wei X, et al. Survival outcomes and progonostic factors of extrahepatic cholangiocarcinoma patients following surgical resection: adjuvant therapy is a favorable prognostic factor[J]. Mol Clin Oncol, 2014, 2(6): 1069-1075.
[9]
Mizuno T, Ebata T, Yokoyama Y, et al. Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis[J]. Surg Today, 2017, 47(2): 182-192.
[10]
NCCN Clinical Practice Guidelines in Oncology-Hepatobiliary Cancers, Version 1.2017[DB/OL].

URL    
[11]
国际肝胆胰学会中国分会,中华医学会外科学分会肝脏外科学组. 胆管癌诊断与治疗——外科专家共识[J]. 临床肝胆病杂志, 2015, 31(1): 12-16.
[12]
Valle J, Wasan H, Palmer DH, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer[J]. N Engl J Med, 2010, 362(14): 1273-1281.
[13]
Kobayashi S, Nagano H, Sakai D, et al. Phase Ⅰ study of adjuvant gemcitabine or S-1 in patients with biliary tract cancers undergoing major hepatectomy: KHBO1003 study[J]. Cancer Chemother Pharmacol, 2014, 74(4): 699-709.
[14]
Kainuma O, Miura F, Furukawa D, et al. Feasibility and efficacy of gemcitabine plus cisplatin combination therapy after curative resection for biliary tract cancer[J]. J Hepatobiliary Pancreat Sci, 2015, 22(11): 789-794.
[15]
Yamanaka K, Hatano E, Kanai M, et al. A single-center analysis of the survival benefits of adjuvant gemcitabine chemotherapy for biliary tract cancer[J]. Int J Clin Oncol, 2014, 19(3): 485-489.
[16]
Stein A, Arnold D, Bridgewater J, et al. Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase Ⅲ trial[J]. BMC Cancer, 2015, 15: 564.
[17]
Eckel F, Schmid RM. Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials[J]. Br J Cancer, 2007, 96(6): 896-902.
[18]
Primrose JN, Fox R, Palmer DH, et al. Adjuvant capecitabine for biliary tract cancer: The BILCAP randomized study[J]. J Clin Oncol, 2017, 35(15_suppl): 4006.
[19]
Wirasorn K, Ngamprasertchai T, Khuntikeo N, et al. Adjuvant chemotherapy in resectable cholangiocarcinoma patients[J]. J Gastroenterol Hepatol, 2013, 28(12): 1885-1891.
[20]
Gwak HK, Kim WC, Kim HJ, et al. Extrahepatic bile duct cancers: surgery alone versus surgery plus postoperative radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2010, 78(1): 194-198.
[21]
Kim S, Kim SW, Bang YJ, et al. Role of postoperative radiotherapy in the management of extrahepatic bile duct cancer[J]. Int J Radiat Oncol Biol Phys, 2002, 54(2): 414-419.
[22]
Nelson JW, Ghafoori AP, Willett CG, et al. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma[J]. Int J Radiat Oncol Biol Phys, 2009, 73(1): 148-153.
[23]
Hughes MA, Frassica DA, Yeo CJ, et al. Adjuvant concurrent chemoradiation for adenocarcinoma of the distal common bile duct[J]. Int J Radiat Oncol Biol Phys, 2007, 68(1): 178-182.
[24]
Dover LL, Oster RA, McDonald AM, et al. Impact of adjuvant chemoradiation on survival in patients with resectable cholan-giocarcinoma[J]. HPB (Oxford), 2016, 18(10): 843-850.
[25]
Ben-Josef E, Guthrie KA, El-Khoueiry AB, et al. SWOG S0809: A Phase Ⅱ intergroup trial of adjuvant capecitabine and gemcitabine followed by radiotherapy and concurrent capecitabine in extrahepatic cholangiocarcinoma and gallbladder carcinoma[J]. J Clin Oncol, 2015, 33(24): 2617-2622.
[1] 马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.
[2] 徐楠, 杨云川, 周迟, 马翔, 鲁正, 崔培元. 脾动脉结扎在肝门胆管癌行大范围肝切除中的临床作用研究[J/OL]. 中华普通外科学文献(电子版), 2024, 18(04): 271-274.
[3] 乌吉斯古楞, 哈斯高娃. mir-98-5p、ALKBH1在肝门部胆管癌组织中表达及与临床病理特征的关系[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(02): 184-187.
[4] 黎熊, 曹永宽. 不同远切缘距离的ISR在局部进展期直肠癌新辅助治疗后的临床研究[J/OL]. 中华普外科手术学杂志(电子版), 2023, 17(04): 443-446.
[5] 范伟强, 林师佈, 孙传伟, 宋奇锋, 李望, 符誉, 陈艾. 不同切除范围的Bismuth-Corlette Ⅲ、Ⅳ型腹腔镜肝门部胆管癌手术临床对比分析[J/OL]. 中华普外科手术学杂志(电子版), 2023, 17(04): 423-426.
[6] 宋小飞, 巫嘉文, 孙阳. 输尿管开口周围膀胱黏膜预离断联合早期膀胱灌注化疗在上尿路尿路上皮癌根治术中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 479-484.
[7] 刘康, 洪礼虎, 刘根, 彭力, 李祥攀. 复方红豆杉胶囊联合GP化疗对晚期NSCLC疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(02): 284-287.
[8] 张润锦, 阳盼, 林燕斯, 刘尊龙, 刘建平, 金小岩. EB病毒相关胆管癌伴多发转移一例及国内文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 865-869.
[9] 陈明政, 栗玉龙, 唐流康, 谢峰. IDH1突变应用于肝内胆管癌治疗的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(01): 103-108.
[10] 聂云贵, 肖广发. 胆管内乳头状黏液瘤三例诊治及文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(01): 72-77.
[11] 潘冰, 吕少诚, 赵昕, 李立新, 郎韧, 贺强. 淋巴结清扫数目对远端胆管癌胰十二指肠切除手术疗效的影响[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 608-612.
[12] 田驹, 孙伯洋, 杨荣华, 赵向前. 术中意外发现肝外胆管绒毛管状腺瘤的外科处理经验:附两例报道并文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 567-571.
[13] 李斌奎. 不可切除肝内胆管细胞癌的转化治疗[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 511-516.
[14] 陈雪岩, 孟兴凯. 肝门空肠吻合术在肝门部胆管癌根治术中的应用价值[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(04): 440-443.
[15] 崔精, 鲍一帆, 沈晓明, 杨增辉, 高森, 鲍传庆. 结直肠癌中circMFSD12对肿瘤细胞功能及5-FU敏感性的调控[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 294-302.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?