系统评价日间手术腹腔镜胆囊切除术（OPLC）的有效性及安全性。

计算机检索Clinical Trials、EMbase、Web of Science、PubMed、The Cochrane Library（2018年2期）、中国知网（CNKI）、中国生物医学文献（CBM）、万方和维普数据库等，搜集国内外公开发表的有关OPLC的相关研究，检索时限均从建库至2018年2月。文献筛选、提取资料并评价纳入研究的偏倚风险由2名研究者独立进行，采用RevMan 5.3软件进行Meta分析。

共纳入12篇文献共5 232例LC患者。OPLC组在住院费用[SMD= -2.28，95% CI（-3.33，-1.23），P<0.000 1]、并发症[OR=0.64，95% CI（0.44，0.93），P=0.02]、中转开腹率[OR=0.31，95% CI（0.15，0.67），P=0.003]、术前等待时间[SMD=-2.50，95% CI（-4.15，-0.86），P=0.003]方面均优于住院腹腔镜胆囊切除（IPLC）组，而健康教育满意度[OR=0.27，95% CI（0.12，0.65），P=0.003]存在劣势，两组总体满意度[OR=1.20，95% CI（0.84，1.71），P=0.33]、再入院率 [OR=0.54，95% CI（0.20，1.50），P=0.24]、手术时间[SMD=-0.22，95% CI（-0.52，0.08），P=0.16]比较，差异无统计学意义。

与常规住院手术比较，OPLC可显著缩短患者术前等待时间，降低患者住院费用，减少术后并发症及中转开腹的发生率，且并不增加患者的再入院率及手术时间，但可能会影响患者的健康教育满意度。本分析因原始资料所限可能存在偏倚，需要开展更多高质量的研究予以验证。

To systematically evaluate the safety and efficacy of ambulatory surgery outpatient laparoscopic cholecystectomy (OPLC).

Databases such as Clinical Trails, EMbase, Web of Science, PubMed, the Cochrane Library (Issue 2, 2018), Chinese National Knowledge Infrastructure, Chinese Biological Medical Database, Wanfang Database and VIP Chinese Science & Technology Journal Database from inception to February 2018 were searched to find out domestic and abroad published literature of OPLC. Two reviewers independently selected literatures, extracted data and assessed quality of the included studies. Meta-analysis was performed by using RevMan 5.3 software.

A total of twelve articles involving 5 232 patients with LC were included. Meta-analysis indicated that the OPLC group was more efficient than the inpatient laparoscopic cholecystectomy (IPLC) group in hospitalization expenses [SMD=-2.28, 95% CI (-3.33, -1.23), P<0.000 1], postoperative complications [OR=0.64, 95% CI (0.44, 0.93, P=0.02], the conversion to laparotomy rate [OR=0.31, 95% CI (0.15, 0.67), P=0.003], preoperative waiting time [SMD=-2.50, 95% CI (-4.15, -0.86), P=0.003], while with less advantage in health education satisfaction [OR=0.27, 95% CI (0.12, 0.65), P=0.003]. There were no statistically significant differences in overall satisfaction [OR=1.20, 95% CI (0.84, 1.71), P=0.33], readmission rate [OR=0.54, 95% CI (0.20, 1.50), P=0.24] or operation time [SMD= -0.22, 95% CI (-0.52, 0.08), P=0.16] between the two groups.

Compared with conventional surgery, OPLC can significantly shorten the preoperative waiting time, lower the hospitalization expenses, reduce the incidence of postoperative complications and the conversion rate to laparotomy, and does not increase the rate of readmission and surgical time, and drop the patient's health education satisfaction levels. Due to original data's limitation, our conclusion may have bias, and needs more high quality researches to verify.