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中华普通外科学文献(电子版) ›› 2019, Vol. 13 ›› Issue (01) : 21 -24. doi: 10.3877/cma.j.issn.1674-0793.2019.01.003

所属专题: 文献

论著

Luminal B型乳腺癌骨转移患者的临床特点和预后分析
陈涛1, 司丕蕾1, 贾琳娇1, 韩智培1, 汪操1, 鲁鹤臻1, 蜜雪芳1, 李文涛1,()   
  1. 1. 450003 郑州大学人民医院(河南省人民医院)乳腺外科
  • 收稿日期:2018-04-22 出版日期:2019-02-01
  • 通信作者: 李文涛
  • 基金资助:
    河南省医学科技攻关计划项目省部共建项目(201601013)

Clinical characteristics and prognosis of luminal B subtype breast cancer patients with bone metastasis

Tao Chen1, Pilei Si1, Linjiao Jia1, Zhipei Han1, Cao Wang1, Hezhen Lu1, Xuefang Mi1, Wentao Li1,()   

  1. 1. Department ofBreast Surgery, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
  • Received:2018-04-22 Published:2019-02-01
  • Corresponding author: Wentao Li
  • About author:
    Corresponding author: Li Wentao, Email:
引用本文:

陈涛, 司丕蕾, 贾琳娇, 韩智培, 汪操, 鲁鹤臻, 蜜雪芳, 李文涛. Luminal B型乳腺癌骨转移患者的临床特点和预后分析[J/OL]. 中华普通外科学文献(电子版), 2019, 13(01): 21-24.

Tao Chen, Pilei Si, Linjiao Jia, Zhipei Han, Cao Wang, Hezhen Lu, Xuefang Mi, Wentao Li. Clinical characteristics and prognosis of luminal B subtype breast cancer patients with bone metastasis[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(01): 21-24.

目的

探讨luminal B型乳腺癌骨转移患者的临床特点和预后情况。

方法

收集2004年1月至2012年1月郑州大学人民医院诊治的luminal B型乳腺癌骨转移患者128例,其中75例人表皮生长因子受体(HER)-2阴性,53例HER-2阳性,回顾性分析其临床特点和预后。

结果

两组患者在骨转移确诊年龄、原发肿瘤大小、腋窝淋巴结转移数目和术后骨转移发生的时间方面的差异有统计学意义(χ2=4.477、6.927、12.209、11.222,P=0.034、0.023、0.002、0.004)。Luminal B型HER-2阴性乳腺癌患者发生骨转移后的中位生存时间为29.8个月,5年生存率22.7%,HER-2阳性乳腺癌患者分别为27.1个月和20.7%,两组患者骨转移后的生存时间差异无统计学意义(χ2=0.398,P=0.528)。

结论

Luminal B型HER-2阳性比luminal B型HER-2阴性乳腺癌骨转移患者更具有发病年龄大、原发肿瘤直径大、腋窝淋巴结转移数目多、术后发生骨转移时间早等特点,但两种类型患者的预后无显著差异。

Objective

To investigate the clinical characteristics and prognosis of luminal B subtype breast cancer patients with bone metastases.

Methods

The data of one hundred and twenty-eight cases of luminal B subtype breast cancer with bone metastases were collected from January 2004 to January 2012, 75 of whom were HER-2 negative and 53 were HER-2 positive. The clinical characteristics and prognosis were analyzed retrospectively.

Results

There were statistically significant differences in the confirmed age of bone metastases, the size of the primary tumor, the number of axillary lymph node metastases, and the time of postoperative bone metastasis between the two groups (χ2=4.477, 6.927, 12.209, 11.222, P=0.034, 0.023, 0.002, 0.004). The median survival time and 5-year survival rate of luminal B HER-2 negative type breast cancer patients after bone metastases were 29.8 months and 22.7%, and 27.1 months and 20.7% respectively for luminal B HER-2 positive type breast cancer patients. There was no significant difference in survival time after bone metastasis between the two groups (χ2=0.398, P=0.528).

Conclusion

Luminal B HER-2 positive type is more common than luminal B HER-2 negative breast cancer patients with bone metastasis in older age, larger diameter of primary tumor, more axillary lymph node metastasis, and earlier bone metastasis after surgery. There is no significant difference in the prognosis of two type patients.

表1 128例luminal B型乳腺癌骨转移患者的病理特点[例(%)]
表2 128例luminal B型乳腺癌骨转移临床特点[例(%)]
图1 HER-2阴性和HER-2阳性乳腺癌骨转移患者的生存曲线
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