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中华普通外科学文献(电子版) ›› 2021, Vol. 15 ›› Issue (04) : 304 -308. doi: 10.3877/cma.j.issn.1674-0793.2021.04.015

综述

程序性死亡受体1及其配体PD-L1、细胞毒性T淋巴细胞相关抗原4抑制剂在晚期肝癌治疗中的进展
王俊旗1, 徐锋1,()   
  1. 1. 110004 沈阳,中国医科大学附属盛京医院普通外科
  • 收稿日期:2021-04-15 出版日期:2021-08-03
  • 通信作者: 徐锋
  • 基金资助:
    辽宁省自然科学基金项目(20180551193,2020-MS-181); 盛京医院345人才工程计划项目(40B)

Progress of inhibitors programmed death receptor-1, PD-L1 and CTLA-4 in the treatment of advanced liver cancer

Junqi Wang1, Feng Xu1,()   

  1. 1. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2021-04-15 Published:2021-08-03
  • Corresponding author: Feng Xu
引用本文:

王俊旗, 徐锋. 程序性死亡受体1及其配体PD-L1、细胞毒性T淋巴细胞相关抗原4抑制剂在晚期肝癌治疗中的进展[J/OL]. 中华普通外科学文献(电子版), 2021, 15(04): 304-308.

Junqi Wang, Feng Xu. Progress of inhibitors programmed death receptor-1, PD-L1 and CTLA-4 in the treatment of advanced liver cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(04): 304-308.

肝细胞癌(HCC)是最常见的原发性肝癌,尽管已有相对成熟且系统的治疗方案,但总体治疗效果尚不令人满意。针对晚期HCC患者的治疗,除了酪氨酸激酶抑制剂外,免疫检查点抑制剂(ICIs)的使用日益广泛,并且取得了不错的效果。本文通过总结细胞毒性T淋巴细胞相关抗原4(CTLA-4)、程序性死亡受体1(PD-1)及其配体PD-L1抑制剂在晚期HCC治疗中的最新进展,以指导临床治疗和研究。

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Although there are relatively mature and systematic treatment regimens, the overall therapeutic effect of HCC is still unsatisfactory. In addition to tyrosine kinase inhibitors, immune checkpoint inhibitors (ICIs) have been widely used for advanced HCC patients and achieved good results. In this review, we summarize the latest progress of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed death receptor-1 (PD-1) and programmed death receptor-1 ligand (PD-L1) inhibitors in the treatment of advanced HCC, aiming to guide the clinical treatment and research.

表1 正在进行中的CTLA-4抑制剂联合其他药物治疗晚期HCC相关研究
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