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中华普通外科学文献(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 386 -390. doi: 10.3877/cma.j.issn.1674-0793.2021.05.017

综述

进展期胃癌新辅助化疗争议的研究进展
翟育豪1, 郑智1, 邓薇1, 白志刚1, 尹杰1, 张军1,()   
  1. 1. 100035 北京,首都医科大学附属北京友谊医院普外科
  • 收稿日期:2021-01-07 出版日期:2021-09-28
  • 通信作者: 张军
  • 基金资助:
    北京市科委重大项目资金资助(D171100006517003); 北京市医院管理局培育计划项目(PX2020001); 北京友谊医院院启动课题项目(Y2018-3); 首都医科大学2021年教育教学改革研究课题项目(2021JYY106)

Advances in the controversies of neoadjuvant chemotherapy for advanced gastric cancer

Yuhao Zhai1, Zhi Zheng1, Wei Deng1, Zhigang Bai1, Jie Yin1, Jun Zhang1,()   

  1. 1. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100035, China
  • Received:2021-01-07 Published:2021-09-28
  • Corresponding author: Jun Zhang
引用本文:

翟育豪, 郑智, 邓薇, 白志刚, 尹杰, 张军. 进展期胃癌新辅助化疗争议的研究进展[J/OL]. 中华普通外科学文献(电子版), 2021, 15(05): 386-390.

Yuhao Zhai, Zhi Zheng, Wei Deng, Zhigang Bai, Jie Yin, Jun Zhang. Advances in the controversies of neoadjuvant chemotherapy for advanced gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(05): 386-390.

进展期胃癌的新辅助化疗一直以来都是临床工作和研究中的热点问题,其研究的焦点主要集中在方案选择与预测因子的选定上。对于一期无法达到根治性切除的胃癌患者行新辅助化疗可能在一定程度上改善患者预后,但哪种病理分型的胃癌更适合新辅助化疗,哪一类的新辅助化疗方案能使患者更大获益目前仍存在争议。本文旨在总结近年来进展期胃癌的国内外相关文献,对新辅助化疗适应证、化疗方案、化疗的预测与评价以及新辅助化疗对手术的影响等方面进行综述,从而体现新辅助化疗对进展期胃癌患者的帮助。

Neoadjuvant chemotherapy for advanced gastric cancer has been becoming the hot-spot issue in clinic. The focus of the research is mainly on the selection of schemes and predictive factors. Neoadjuvant chemotherapy may improve the prognosis of gastric cancer patients whose tumor can not be radically resected at the first stage. However, there are still controversies about which pathological type of gastric cancer is suitable for neoadjuvant chemotherapy and which scheme of neoadjuvant chemotherapy will bring greater help to the patients. The purpose of this article is to summarize the relevant literatures on advanced gastric cancer in recent years and make the conclusion about the indication, prediction and evaluation of the chemotherapy regimen and the impact of neoadjuvant chemotherapy on surgery, so as to provide help of neoadjuvant chemotherapy for patients with advanced gastric cancer.

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