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中华普通外科学文献(电子版) ›› 2024, Vol. 18 ›› Issue (04) : 305 -308. doi: 10.3877/cma.j.issn.1674-0793.2024.04.014

综述

中晚期肝细胞癌介入治疗的进展及前景
汤宏涛1, 何坤1,()   
  1. 1. 528400 广东医科大学附属中山市人民医院肝胆外科
  • 收稿日期:2023-11-17 出版日期:2024-08-01
  • 通信作者: 何坤
  • 基金资助:
    广东省科技攻关计划(2017B1044)

Progress and prospects of interventional therapy for advanced hepatocellular carcinoma

Hongtao Tang1, Kun He1,()   

  1. 1. Department of Hepatobiliary Surgery, Zhongshan City People’s Hospital Affiliated to Guangdong Medical University, Zhongshan 528400, China
  • Received:2023-11-17 Published:2024-08-01
  • Corresponding author: Kun He
引用本文:

汤宏涛, 何坤. 中晚期肝细胞癌介入治疗的进展及前景[J]. 中华普通外科学文献(电子版), 2024, 18(04): 305-308.

Hongtao Tang, Kun He. Progress and prospects of interventional therapy for advanced hepatocellular carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(04): 305-308.

肝细胞癌(HCC)是国内常见恶性肿瘤之一,严重威胁人民身体健康。外科手术切除病灶是HCC患者获得长期生存的主要手段之一,但有部分患者在初诊时已处于中晚期而不可行手术治疗。近年来介入治疗不断发展,在HCC领域取得诸多优异成绩,合理应用可有效延长患者生存时间。本文就血管介入治疗在中晚期HCC治疗领域中的临床应用研究进展和前景进行论述。

Hepatocellular carcinoma (HCC) is one of the common malignant tumors in China, which seriously threatens the health. Surgical resection of HCC lesions is one of the main means to achieve long-term survival, but some patients are already at the middle or late stage since the time of initial diagnosis and surgical resection is not feasible. In recent years, interventional therapy has continuously developed and achieved excellent achievements in the field of HCC, and reasonable application can effectively prolong the survival time of patients. This article discusses the clinical research progress and prospects of vascular interventional therapy in the treatment of advanced HCC.

[1]
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2]
Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2019, 394(10204): 1145-1158.
[3]
中国抗癌协会肝癌专业委员会转化治疗协作组. 肝癌转化治疗中国专家共识(2021版) [J]. 中华消化外科杂志, 2021, 20(6): 600-616.
[4]
Fu Z, Li X, Zhong J, et al. Lenvatinib in combination with transarterial chemoembolization for treatment of unresectable hepatocellular carcinoma (uHCC): A retrospective controlled study[J]. Hepatol Int, 2021, 15(3): 663-675.
[5]
Lai Z, He M, Bu X, et al. Lenvatinib, Toripalimab plus hepatic arterial infusion chemotherapy in patients with high-risk advanced hepatocellular carcinoma: A biomolecular exploratory, phase Ⅱ trial[J]. Eur J Cancer, 2022, 174: 68-77.
[6]
He M, Ming S, Lai Z, Li Q. A phase Ⅱ trial of Lenvatinib plus Toripalimab and hepatic arterial infusion chemotherapy as a first-line treatment for advanced hepatocellular carcinoma (LTHAIC study)[J]. J Clin Oncol, 2021, 39 (suppl 15): 4083.
[7]
He MK, Le Y, Li QJ, et al. Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: A prospective non-randomized study[J]. Chin J Cancer, 2017, 36(1): 83.
[8]
Li QJ, He MK, Chen HW, et al. Hepatic arterial infusion of Oxaliplatin, Fluorouracil, and Leucovorin versus transarterial chemoembolization for large hepatocellular carcinoma: A randomized phase Ⅲ trial[J]. J Clin Oncol, 2022, 40(2): 150-160.
[9]
Hu Z, Yang Z, Wang J, et al. Survival benefit of neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy for hepatocellular carcinoma with portal vein tumor thrombus[J]. Front Pharmacol, 2023, 14: 1223632.
[10]
Finn RS, Ryoo BY, Hsu CH, et al. Results from the MORPHEUS-liver study: phase Ⅰb/Ⅱ randomized evaluation of Tiragolumab (tira) in combination with Atezolizumab (atezo) and Bevacizumab (bev) in patients with unresectable, locally advanced or metastatic hepatocellular carcinoma (uHCC)[J]. J Clin Oncol, 2023, suppl 16: abstr 4010.
[11]
Dawson L, Winter K, Knox J, et al. NRG/RTOG 1112: randomized phase Ⅲ study of Sorafenib vs. Stereotactic body radiation therapy (SBRT) followed by Sorafenib in hepatocellular carcinoma (HCC) (NCT01730937)[J]. Int J Radiat Oncol Biol Phys, 2022, 114(5): 1057.
[12]
Qin SK. First-line Lenvatinib plus Pembrolizumab for advanced heptocellular carcinoma: LEAP-002 Asian subgroup analysis[G]. JSMO, 2023.
[13]
Sun T, Ren Y, Sun B, et al. The feasibility of TACE combined with TKIs plus PD-1 antibody for advanced HCC[J]. J Hepatocell Carcinoma, 2023, 10: 447-457.
[14]
Yu B, Zhang N, Feng Y, et al. Tyrosine kinase inhibitors plus Anti-PD-1 antibodies with hepatic arterial infusion chemotherapy or transarterial chemoembolization for unresectable hepatocellular carcinoma[J]. J Hepatocell Carcinoma, 2023, 10: 1735-1748.
[15]
Brozzetti S, D’Alterio C, Bini S, et al. Surgical resection is superior to TACE in the treatment of HCC in a well selected cohort of BCLC-B elderly patients-a retrospective observational study[J]. Cancers (Basel), 2022, 14(18): 4422.
[16]
Liu J, Yan S, Zhang G, et al. A retrospective study of transarterial chemoembolization (TACE) combined with Lenvatinib compared with TACE monotherapy for BCLC B2 stage hepatocellular carcinoma[J]. Oncol Lett, 2023, 26(6): 507.
[17]
Lin LW, Ke K, Yan LY, et al. Efficacy and safety of hepatic artery infusion chemotherapy combined with tyrosine kinase inhibitors plus programmed death-1 inhibitors for hepatocellular carcinoma refractory to transarterial chemoembolization[J]. Front Oncol, 2023, 13: 1178428.
[18]
Xu J, Shen J, Gu S, et al. Camrelizumab in combination with Apatinib in patients with advanced hepatocellular carcinoma (RESCUE): A nonrandomized, open-label, phase Ⅱ trial[J]. Clin Cancer Res, 2021, 27(4): 1003-1011.
[19]
Ren Z, Xu J, Bai Y, et al. Sintilimab plus a Bevacizumab biosimilar (IBI305) versus Sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): A randomised, open-label, phase 2-3 study[J]. Lancet Oncol, 2021, 22(7): 977-990.
[20]
Finn RS, Ikeda M, Zhu AX, et al. PhaseⅠ b study of Lenvatinib plus Pembrolizumab in patients with unresectable hepatocellular carcinoma[J]. J Clin Oncol, 2020, 38(26): 2960-2970.
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