切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2024, Vol. 18 ›› Issue (04) : 308 -312. doi: 10.3877/cma.j.issn.1674-0793.2024.04.015

综述

人表皮生长因子受体2低表达乳腺癌的研究进展及挑战
李雪1, 韩萌萌1, 冯雪园1, 马宁1,()   
  1. 1. 071000 河北省保定市第一中心医院乳腺外科
  • 收稿日期:2023-09-24 出版日期:2024-08-01
  • 通信作者: 马宁

Progress and challenges of human epidermal growth factor receptor 2-low expressing breast cancer

Xue Li1, Mengmeng Han1, Xueyuan Feng1, Ning Ma1,()   

  1. 1. Department of Breast Surgery, Baoding No.1 Central Hospital, Hebei Medical University, Baoding 071000, China
  • Received:2023-09-24 Published:2024-08-01
  • Corresponding author: Ning Ma
引用本文:

李雪, 韩萌萌, 冯雪园, 马宁. 人表皮生长因子受体2低表达乳腺癌的研究进展及挑战[J]. 中华普通外科学文献(电子版), 2024, 18(04): 308-312.

Xue Li, Mengmeng Han, Xueyuan Feng, Ning Ma. Progress and challenges of human epidermal growth factor receptor 2-low expressing breast cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(04): 308-312.

乳腺癌是女性最常见的恶性肿瘤,极大威胁女性身体健康。人表皮生长因子受体2(HER-2)是乳腺癌治疗的重要靶点,针对HER-2阳性乳腺癌靶向治疗的研究已经非常广泛,而HER-2低表达以往被归为阴性乳腺癌,较少能从传统的抗HER-2治疗中获益。但随着抗体偶联药物在HER-2低表达乳腺癌中疗效的确立,使得HER-2低表达成为新的乳腺癌治疗亚型。本文将对HER-2低表达乳腺癌的定义、临床病理特征和预后意义、治疗进展等方面进行总结阐述。

Breast cancer is the most frequently diagnosed cancer in women, which poses a great threat to women’s health. Human epidermal growth factor receptor 2 (HER-2) is an important target for the treatment of breast cancer, and targeted therapy for HER-2-positive breast cancer has been widely studied. HER-2 low expression was previously classified as negative breast cancer and rarely or could not benefit from traditional anti-HER-2 therapy. However, with the established efficacy of antibody-drug conjugates, HER-2-low expressing breast cancer has become a new subtype for treatment. This article will summarize the definition, clinicopathological features, prognosis and treatment progress of HER-2-low expressing breast cancer.

[1]
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2]
中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2021年版)[J]. 中国癌症杂志, 2021, 31(10): 954-1040.
[3]
《乳腺癌HER2检测指南(2019版)》编写组. 乳腺癌HER2检测指南(2019版)[J]. 中华病理学杂志, 2019, 48(3): 169-175.
[4]
Modi S, Jacot W, Yamashita T, et al. Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer[J]. N Engl J Med, 2022, 387(1): 9-20.
[5]
中国抗癌协会国际医疗与交流分会, 中国医师协会肿瘤医师分会乳腺癌学组. 人表皮生长因子受体2低表达乳腺癌临床诊疗共识(2022版)[J]. 中华肿瘤杂志, 2022, 44(12): 1288-1295.
[6]
Guo Y, Xie X, Tang W, et al. Noninvasive identification of HER2-low-positive status by MRI-based deep learning radiomics predicts the disease-free survival of patients with breast cancer[J]. Eur Radiol, 2024, 34(2): 899-913.
[7]
Ramtohul T, Djerroudi L, Lissavalid E, et al. Multiparametric MRI and radiomics for the prediction of HER2-zero, -low, and -positive breast cancers[J]. Radiology, 2023, 308(2): e222646.
[8]
Tarantino P, Hamilton E, Tolaney SM, et al. HER2-low breast cancer: pathological and clinical landscape[J]. J Clin Oncol, 2020, 38(17): 1951-1962.
[9]
Schettini F, Chic N, Brasó-Maristany F, et al. Author correction: clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer[J]. NPJ Breast Cancer, 2023, 9(1): 32.
[10]
Zhang G, Ren C, Li C, et al. Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status[J]. BMC Med, 2022, 20(1): 142.
[11]
Xu H, Han Y, Wu Y, et al. Clinicopathological characteristics and prognosis of HER2-low early-stage breast cancer: A single-institution experience[J]. Front Oncol, 2022, 12: 906011.
[12]
Won HS, Ahn J, Kim Y, et al. Clinical significance of HER2-low expression in early breast cancer: A nationwide study from the Korean Breast Cancer Society[J]. Breast Cancer Res, 2022, 24(1): 22.
[13]
Li Y, Abudureheiyimu N, Mo H, et al. In real life, low-level HER2 expression may be associated with better outcome in HER2-negative breast cancer: A study of the national cancer center, China[J]. Front Oncol, 2022, 11: 774577.
[14]
Denkert C, Seither F, Schneeweiss A, et al. Clinical and molecular characteristics of HER2-low-positive breast cancer: pooled analysis of individual patient data from four prospective, neoadjuvant clinical trials[J]. Lancet Oncol, 2021, 22(8): 1151-1161.
[15]
de Moura Leite L, Cesca MG, Tavares MC, et al. HER2-low status and response to neoadjuvant chemotherapy in HER2 negative early breast cancer[J]. Breast Cancer Res Treat, 2021, 190(1): 155-163.
[16]
Gianni L, Lladó A, Bianchi G, et al. Open-label, phase Ⅱ, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer[J]. J Clin Oncol, 2010, 28(7): 1131-1137.
[17]
Press MF, Finn RS, Cameron D, et al. HER-2 gene amplification, HER-2 and epidermal growth factor receptor mRNA and protein expression, and Lapatinib efficacy in women with metastatic breast cancer[J]. Clin Cancer Res, 2008, 14(23): 7861-7870.
[18]
Burris HA 3rd, Rugo HS, Vukelja SJ, et al. Phase Ⅱ study of the antibody drug conjugate Trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER-2)-positive breast cancer after prior HER2-directed therapy[J]. J Clin Oncol, 2011, 29(4): 398-405.
[19]
Krop IE, LoRusso P, Miller KD, et al. A phase Ⅱ study of Trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with Trastuzumab, Lapatinib, an anthracycline, a taxane, and capecitabine[J]. J Clin Oncol, 2012, 30(26): 3234-3241.
[20]
Banerji U, van Herpen CML, Saura C, et al. Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: A phase 1 dose-escalation and dose-expansion study[J]. Lancet Oncol, 2019, 20(8): 1124-1135.
[21]
Wang J, Liu Y, Zhang Q, et al. RC48-ADC, a HER2-targeting antibody-drug conjugate, in patients with HER2-positive and HER2-low expressing advanced or metastatic breast cancer:A pooled analysis of two studies[J]. J Clin Oncol, 2021, 39(15): 1022.
[22]
Schmid P, Cortés J, Marmé F, et al. Sacituzumab govitecan efficacy in hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer by HER2 immunohistochemistry status in the phase Ⅲ TROPiCS-02 study[J]. Ann Oncol, 2022, 33 (suppl 7): S88–S121.
[23]
Mittendorf EA, Ardavanis A, Symanowski J, et al. Primary analysis of a prospective, randomized, single-blinded phase Ⅱ trial evaluating the HER2 peptide AE37 vaccine in breast cancer patients to prevent recurrence[J]. Ann Oncol, 2016, 27(7): 1241-1248.
[24]
Clifton GT, Hale D, Vreeland TJ, et al. Results of a randomized phase Ⅱb trial of Nelipepimut-S + Trastuzumab versus Trastuzumab to prevent recurrences in patients with high-risk HER2 low-expressing breast cancer[J]. Clin Cancer Res, 2020, 26(11): 2515-2523.
[25]
Yi M, Wu Y, Niu M, et al. Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer[J]. J Immunother Cancer, 2022, 10(12): e005543.
[26]
Wu Y, Zhong R, Ma F. HER2-low breast cancer: novel detections and treatment advances[J]. Crit Rev Oncol Hematol, 2023, 181: 103883.
[27]
Fernandez AI, Liu M, Bellizzi A, et al. Examination of low ERBB2 protein expression in breast cancer tissue[J]. JAMA Oncol, 2022, 8(4): 1-4.
[28]
Lambein K, Van Bockstal M, Vandemaele L, et al. Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance[J]. Am J Clin Pathol, 2013, 140(4): 561-566.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 国际机器人乳腺外科手术专家协作组(专家委员会). 机器人乳腺癌手术专家共识[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 129-139.
[3] 刘炎东, 李恒宇. 新辅助化疗后乳腺癌局部区域的分期评估和治疗的降阶梯策略[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 146-151.
[4] 伍梦妮, 徐志华, 陈彦. DTNBP1基因在三阴性乳腺癌中的作用及其预后价值[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 158-168.
[5] 管枫, 罗斌, 柯晓康, 袁静萍. 少见部位转移性乳腺浸润性小叶癌临床病理特征分析[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 169-174.
[6] 刘世佳, 陶新楠, 史晋宇, 吕文豪, 张亚芬. 乳酸脱氢酶A在乳腺癌中的作用[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 175-179.
[7] 黄海, 周学鲁. 乳腺癌孤立性腹股沟淋巴结转移的诊治现状[J]. 中华乳腺病杂志(电子版), 2024, 18(03): 180-183.
[8] 伍先权, 张立果, 周璇, 梁建深. 乳腺包裹性乳头状癌的临床病理与手术策略联系[J]. 中华普通外科学文献(电子版), 2024, 18(04): 294-297.
[9] 孙建娜, 孔令军, 任崇禧, 穆坤, 王晓蕊. 266例首诊Ⅳ期乳腺癌手术患者预后分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(05): 502-505.
[10] 蔡大明, 陆晓峰, 王行舟, 王萌, 刘颂, 夏雪峰, 沈晓菲, 杜峻峰, 管文贤. 三级淋巴结构在胃神经内分泌瘤中的预后价值及预后预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(04): 401-405.
[11] 刘虹, 王品, 王彬, 任杰超, 张文杰, 吴剑, 刘莹. 经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+Ⅰ期胸肌前假体乳房重建术[J]. 中华普外科手术学杂志(电子版), 2024, 18(04): 419-422.
[12] 康乐平, 张琳, 万舟, 苟勇. 腔镜皮下腺体切除及腋窝淋巴结清扫加假体植入术治疗乳腺癌疗效及并发症分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(04): 427-429.
[13] 张茴, 李一, 代美玲. 植入物在乳房重建中的应用进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(03): 349-352.
[14] 王凯飞, 牟怡平, 李晓辉, 王瑞涛, 侯惠莲, 张月浪. 原发性肝平滑肌肉瘤临床病理特征及疗效分析[J]. 中华肝脏外科手术学电子杂志, 2024, 13(03): 357-362.
[15] 孙鼎, 王滨, 陈香美, 陈意志. 热应激肾病的研究进展[J]. 中华肾病研究电子杂志, 2024, 13(03): 170-176.
阅读次数
全文


摘要