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中华普通外科学文献(电子版) ›› 2025, Vol. 19 ›› Issue (01) : 34 -41. doi: 10.3877/cma.j.issn.1674-0793.2025.01.006

论著

胃癌前哨淋巴结研究的文献计量学与可视化分析
王子萌1, 郑智1, 闫笑生1, 翟育豪1, 张海翘1, 徐瑞2, 陈光勇2, 刘小野1, 尹杰1, 张军1,()   
  1. 1.100050 北京,首都医科大学附属北京友谊医院普通外科
    2.100050 北京,首都医科大学附属北京友谊医院病理科
  • 收稿日期:2024-08-20 出版日期:2025-02-01
  • 通信作者: 张军
  • 基金资助:
    国家自然科学基金资助项目(82300646)北京市自然科学基金资助项目(7232334)北京市属医院科研培育项目(PX20240103、PX2020001)首都卫生发展科研专项项目(2024-2-2028)北京市科委AI+健康协同创新培育项目(Z241100007724004)北京市卫健委研究型病房卓越临床研究计划

Bibliometric and visualized analysis of researches on sentinel lymph node in gastric cancer

Zimeng Wang1, Zhi Zheng1, Xiaosheng Yan1, Yuhao Zhai1, Haiqiao Zhang1, Rui Xu2, Guangyong Chen2, Xiaoye Liu1, Jie Yin1, Jun Zhang1,()   

  1. 1.Department of General Surgery,Beijing Friendship Hospital,Capital Medical University, Beijing 100050, China
    2.Department of Pathology, Beijing Friendship Hospital,Capital Medical University, Beijing 100050, China
  • Received:2024-08-20 Published:2025-02-01
  • Corresponding author: Jun Zhang
引用本文:

王子萌, 郑智, 闫笑生, 翟育豪, 张海翘, 徐瑞, 陈光勇, 刘小野, 尹杰, 张军. 胃癌前哨淋巴结研究的文献计量学与可视化分析[J/OL]. 中华普通外科学文献(电子版), 2025, 19(01): 34-41.

Zimeng Wang, Zhi Zheng, Xiaosheng Yan, Yuhao Zhai, Haiqiao Zhang, Rui Xu, Guangyong Chen, Xiaoye Liu, Jie Yin, Jun Zhang. Bibliometric and visualized analysis of researches on sentinel lymph node in gastric cancer[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(01): 34-41.

目的

系统检索截至2024 年7 月31 日的所有相关文献,对胃癌前哨淋巴结研究领域进行文献计量学分析,探索研究热点和趋势。

方法

检索Web of Science 核心合集数据库,获取胃癌前哨淋巴结相关研究,采用VOSviewer 1.6.20 和CiteSpace 6.2.R6 软件对国家(地区)、机构、作者、期刊、关键词进行文献计量学和可视化分析。

结果

共纳入604 篇文献。发文量最多的国家、机构和作者分别为日本、庆应义塾大学和 Kitagawa Y。Ann Surg Oncol 是发文量最多的期刊,Ann Surg 是该领域最具影响力的期刊。施引期刊的所属领域主要集中在 “Surgery,Clinical, Biology”(“手术,临床,生物学”);被引期刊的所属领域主要集中在 “Medicine,Molecular,Nursing”(“药物,分子,护理”)领域。共被引次数排在首位的参考文献为J Surg Oncol 2011:The clinical use of indocyanine green as a nearinfrared fluorescent contrast agent for image-guided oncologic surgery。关键词聚类分析将关键词分为4类:个性化精准手术、胃癌前哨淋巴结示踪、前哨淋巴结病理诊断和前哨淋巴结导航手术。研究热点则是多中心研究、前哨淋巴引流区清扫术、吲哚菁绿和前哨导航手术。

结论

前哨淋巴结在胃癌诊治中具有广阔的应用前景,越来越多的学者致力于开展相关研究,并在胃癌的精准治疗、生物学和诊断方面得到了初步成果。本研究结果可为开展胃癌前哨淋巴结相关研究工作的学者提供参考。

Objective

Based on the bibliometric analysis of sentinel lymph node research in gastric cancer, the research hotspots and trends in this field were discussed by systematically searching all relevant literature up to July 31, 2024.

Methods

The Web of Science core collection database was searched to obtain related studies.The bibliometric analysis and data visualization were carried out using VOSviewer 1.6.20 and CiteSpace 6.2.R6 software to analyze the country, institution, author, journal and keywords.

Results

A total of 604 articles were included.The countries, institutions and authors with the highest number of publications were Japan, Keio University, and Kitagawa Y, respectively.Ann Surg Oncol was the mostly published journal, and Ann Surg was the mostly influential journal in the field.The cited journals mainly focused on the fields of “ Surgery, Clinical, Biology”; and the fields of the cited journals were mainly in the field of “ Medicine, Molecular, Nursing”.The mostly cited reference was J Surg Oncol 2011: The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.Keyword cluster analysis divided the keywords into four categories: personalized precision surgery,sentinel lymph node tracing of gastric cancer, sentinel lymph node pathological diagnosis and sentinel lymph node navigation surgery.Multicenter studies, sentinel lymphatic basin dissection, indocyanine green, and sentinel navigation surgery were the current research hotspots.

Conclusions

Sentinel lymph node has a broad application prospect and has obtained preliminary results in the precision treatment and biology of gastric cancer.The results of this study can provide reference for scholars who carry out research on sentinel lymph nodes in gastric cancer.

图1 作者合作网络分析 A 为作者合作网络图谱;B 为作者合作网络时间叠加图谱
表1 发文量和共被引次数名列前十作者的发文情况
图2 发文机构及合作网络分析 A 为机构间的合作网络图谱;B 为机构间的合作网络时间叠加图谱
表2 发文量排名前十的机构情况
图3 发文国家(地区)国际合作网络分析 A 为国家间的合作网络图谱;B 为国家间的合作网络时间叠加图谱
表3 发文量前九名的国家/地区
表4 7 项正在进行的胃癌前哨淋巴结相关临床研究
图4 发文量排名前十的期刊和平均被引用频次
图5 双图叠加分析结果 引用链接从左侧的期刊出发,指向其右侧的期刊。每个链接的颜色区分了其学科来源,不同的色调作为不同学科的标记。顶部的条形图表示随时间的出版物动态稳定性,较低的条形表示在出版场所方面相对稳定的年份,较高的条形表示更多样化的分布
图6 文献共被引图谱
表5 被引用频次最多的前十篇文献
图7 关键词分析 A 为关键词共现图谱;B 为关键词时间叠加共现图谱
图8 关键词突现分析图
[1]
Vidya R, Khosla M, Laws S, et al.Axillary sentinel lymph node identification using superparamagnetic iron oxide versus radioisotope in early stage breast cancer: the UK SentiMag trial(SMART study)[J].Surgeon, 2023, 21(2): 128-134.
[2]
de Jongh C, Triemstra L, van der Veen A, et al.Pattern of lymph node metastases in gastric cancer: A side-study of the multicenter LOGICA-trial[J].Gastric Cancer, 2022, 25(6): 1060-1072.
[3]
Kim YW, Min JS, Yoon HM, et al.Laparoscopic sentinel node navigation surgery for stomach preservation in patients with early gastric cancer: A randomized clinical trial[J].J Clin Oncol, 2022,40(21): 2342-2351.
[4]
Sung H, Ferlay J, Siegel RL, et al.Global Cancer Statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin, 2021, 71(3): 209-249.
[5]
Palaia R, Cremona F, Delrio P, et al.Sentinel node biopsy in gastric cancer[J].J Chemother, 1999, 11(3): 230-231.
[6]
Hiratsuka M, Miyashiro I, Ishikawa O, et al.Application of sentinel node biopsy to gastric cancer surgery[J].Surgery, 2001, 129(3):335-340.
[7]
Kitagawa Y, Fujii H, Mukai M, et al.Radio-guided sentinel node detection for gastric cancer[J].Br J Surg, 2002, 89(5): 604-608.
[8]
Bok GH, Kim YJ, Jin SY, et al.Endoscopic submucosal dissection with sentinel node navigation surgery for early gastric cancer[J].Endoscopy, 2012, 44(10): 953-956.
[9]
Takeuchi M, Kawakubo H, Shimada A, et al.Assessment of lymphatic flow based on the sentinel node concept in early gastric adenocarcinoma that satisfies expanded endoscopic resection criteria[J].Gastric Cancer, 2020, 23(3): 531-539.
[10]
Eom BW, Yoon HM, Min JS, et al.Prospective multicenter feasibility study of laparoscopic sentinel basin dissection after endoscopic submucosal dissection for early gastric cancer: SENORITA 2 trial protocol[J].J Gastric Cancer, 2019, 19(2): 157-164.
[11]
Kitakata H, Itoh T, Kinami S, et al.Sealed endoscopic fullthickness resection for gastric cancer: A pilot study in an ex vivo and in vivo porcine model[J].Endosc Int Open, 2019, 7(1):e36-e42.
[12]
Kitagawa Y, Takeuchi H, Takagi Y, et al.Sentinel node mapping for gastric cancer: A prospective multicenter trial in Japan[J].J Clin Oncol, 2013, 31(29): 3704-3710.
[13]
Kim H, Lee SK, Kim YM, et al.Fluorescent iodized emulsion for pre- and intraoperative sentinel lymph node imaging: validation in a preclinical model[J].Radiology, 2015, 275(1): 196-204.
[14]
Huang Y, Pan M, Deng Z, et al.How useful is sentinel lymph node biopsy for the status of lymph node metastasis in cT1N0M0 gastric cancer? A systematic review and meta-analysis[J].Updates Surg,2021, 73(4): 1275-1284.
[15]
Osterkamp J, Strandby RB, Nerup N, et al.Time to maximum indocyanine green fluorescence of gastric sentinel lymph nodes and feasibility of combined indocyanine green/sodium fluorescein gastric lymphography[J].Langenbecks Arch Surg, 2021, 406(8):2717-2724.
[16]
Cousins A, Krishnan S, Krishnan G, et al.Preclinical evaluation of sentinel node localization in the stomach via mannose-labelled magnetic nanoparticles and indocyanine green[J].Surg Endosc,2023, 37(8): 6185-6196.
[17]
Knospe L, Gockel I, Jansen-Winkeln B, et al.New intraoperative imaging tools and image-guided surgery in gastric cancer surgery[J].Diagnostics (Basel), 2022, 12(2): 507.
[18]
Zhong Q, Chen QY, Huang XB, et al.Clinical implications of indocyanine green fluorescence imaging-guided laparoscopic lymphadenectomy for patients with gastric cancer: A cohort study from two randomized, controlled trials using individual patient data[J].Int J Surg, 2021, 94: 106120.
[19]
Chen QY, Zhong Q, Li P, et al.Comparison of submucosal and subserosal approaches toward optimized indocyanine green tracerguided laparoscopic lymphadenectomy for patients with gastric cancer (FUGES-019): A randomized controlled trial[J].BMC Med,2021, 19(1): 276.
[20]
Hölscher AH, Law S.Esophagogastric junction adenocarcinomas:individualization of resection with special considerations for Siewert type , and Nishi types EG, E=G and GE cancers[J].Gastric Cancer, 2020, 23(1): 3-9.
[21]
Burian M, Stein HJ, Sendler A, et al.Sentinel node detection in Barrett's and cardia cancer[J].Ann Surg Oncol, 2004, 11(3 Suppl):255s-258s.
[22]
Grotenhuis BA, Wijnhoven BP, van Marion R, et al.The sentinel node concept in adenocarcinomas of the distal esophagus and gastroesophageal junction[J].J Thorac Cardiovasc Surg, 2009,138(3): 608-612.
[23]
Thompson SK, Bartholomeusz D, Devitt PG, et al.Feasibility study of sentinel lymph node biopsy in esophageal cancer with conservative lymphadenectomy[J].Surg Endosc, 2011, 25(3): 817-825.
[24]
Mitsumori N, Nimura H, Takahashi N, et al.Sentinel lymph node navigation surgery for early stage gastric cancer[J].World J Gastroenterol, 2014, 20(19): 5685-5693.
[25]
Gabrielson S, Tsai JA, Celebioglu F, et al.Sentinel lymph node imaging with sequential SPECT/CT lymphoscintigraphy before and after neoadjuvant chemoradiotherapy in patients with cancer of the oesophagus or gastro-oesophageal junction - a pilot study[J].Cancer Imaging, 2018, 18(1): 53.
[26]
Ishii K, Kinami S, Funaki K, et al.Detection of sentinel and nonsentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer[J].J Exp Clin Cancer Res, 2008, 27(1): 7.
[27]
Miyashiro I, Hiratsuka M, Sasako M, et al.High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302[J].Gastric Cancer, 2014, 17(2): 316-323.
[28]
Park JY, Kim YW, Ryu KW, et al.Assessment of laparoscopic stomach preserving surgery with sentinel basin dissection versus standard gastrectomy with lymphadenectomy in early gastric cancer-a multicenter randomized phase clinical trial (SENORITA trial) protocol[J].BMC Cancer, 2016, 16: 340.
[29]
Shimizu Y, Takeuchi H, Sakakura Y, et al.Molecular detection of sentinel node micrometastases in patients with clinical N0 gastric carcinoma with real-time multiplex reverse transcriptionpolymerase chain reaction assay[J].Ann Surg Oncol, 2012, 19(2):469-477.
[30]
Shimada A, Takeuchi H, Nishi T, et al.Utility of the one-step nucleic acid amplification assay in sentinel node mapping for early gastric cancer patients[J].Gastric Cancer, 2020, 23(3): 418-425.
[31]
Takeuchi M, Takeuchi H, Kawakubo H, et al.Risk factors for lymph node metastasis in non-sentinel node basins in early gastric cancer:sentinel node concept[J].Gastric Cancer, 2019, 22(1): 223-230.
[32]
Morita D, Tsuda H, Ichikura T, et al.Analysis of sentinel node involvement in gastric cancer[J].Clin Gastroenterol Hepatol, 2007,5(9): 1046-1052.
[33]
Kinami S, Miwa K, Ishii K, et al.Limited surgery for early gastric cancer using lymphatic basin dissection--a sure method of sentinel node biopsy for gastric cancer[J].Gan To Kagaku Ryoho,2005, 32(3): 405-410.
[34]
Lee YJ, Jeong SH, Hur H, et al.Prospective multicenter feasibility study of laparoscopic sentinel basin dissection for organ preserving surgery in gastric cancer: quality control study for surgical standardization prior to phase trial[J].Medicine (Baltimore), 2015,94(43): e1894.
[35]
Kinami S, Nakamura N, Miyashita T, et al.nPTD classification:An updated classification of gastric cancer location for function preserving gastrectomy based on physiological lymphatic flow[J].BMC Cancer, 2021, 21(1): 1231.
[36]
Hiramatsu Y, Kikuchi H, Takeuchi H.Function-preserving gastrectomy for early gastric cancer[J].Cancers (Basel), 2021,13(24): 6223.
[37]
Oh SE, An JY, Min JS, et al.Determining the precise extent of sentinel basins during laparoscopic gastrectomy for early gastric cancer[J].World J Surg Oncol, 2023, 21(1): 60.
[38]
Okubo K, Arigami T, Matsushita D, et al.Evaluation of postoperative quality of life by PGSAS-45 following local gastrectomy based on the sentinel lymph node concept in early gastric cancer[J].Gastric Cancer, 2020, 23(4): 746-753.
[39]
Hur H, Lee YJ, Kim YW, et al.Clinical efficacy of laparoscopic sentinel node navigation surgery for stomach preservation in patients with early gastric cancer: 5-year results of the SENORITA trial[J].Ann Surg, 2024.
[40]
Kinami S, Aizawa M, Yamashita H, et al.The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey[J].Gastric Cancer, 2021, 24(1): 22-30.
[41]
Li GZ, Doherty GM, Wang J.Surgical management of gastric cancer: A review[J].JAMA Surg, 2022, 157(5): 446-454.
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