切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2025, Vol. 19 ›› Issue (02) : 130 -134. doi: 10.3877/cma.j.issn.1674-0793.2025.02.012

综述

艾司氯胺酮在围手术期镇痛的应用进展
张小媚1, 温君琳2, 廖小卒2, 黄锡强2, 李斌飞1,2,()   
  1. 1. 524023 湛江,广东医科大学
    2. 528404 广东省中山市人民医院麻醉科
  • 收稿日期:2024-10-11 出版日期:2025-04-01
  • 通信作者: 李斌飞
  • 基金资助:
    中山市社会公益与基础研究项目(2023B1017)

Progress of the use of esketamine in perioperative analgesia

Xiaomei Zhang1, Junlin Wen2, Xiaozu Liao2, Xiqiang Huang2, Binfei Li1,2,()   

  1. 1. Guangdong Medical University, Zhanjiang 524023, China
    2. Department of Anesthesiology, Zhongshan City People' s Hospital, Zhongshan 528404, China
  • Received:2024-10-11 Published:2025-04-01
  • Corresponding author: Binfei Li
引用本文:

张小媚, 温君琳, 廖小卒, 黄锡强, 李斌飞. 艾司氯胺酮在围手术期镇痛的应用进展[J/OL]. 中华普通外科学文献(电子版), 2025, 19(02): 130-134.

Xiaomei Zhang, Junlin Wen, Xiaozu Liao, Xiqiang Huang, Binfei Li. Progress of the use of esketamine in perioperative analgesia[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(02): 130-134.

艾司氯胺酮是一种具有显著镇痛效应的N-甲基-D-天冬氨酸受体的非竞争性抑制药,在麻醉诱导与维持、抗抑郁治疗等方面呈现出显著优势。与传统的镇痛药物相比,艾司氯胺酮可提供多维的镇痛效果,效力更高且不良反应少,在围手术期镇痛的应用越来越受到关注。本文对艾司氯胺酮镇痛的机制及其在围手术期镇痛中的应用进行综述,以期为其在围手术期镇痛应用提供参考。

Esketamine is a non-competitive N-methyl-D-aspartate receptor antagonist with significant analgesic effects, and has shown important advantages in the antidepressant treatment, anesthesia induction and maintenance. Compared with traditional analgesic drugs, esketamine has a unique mechanism of action, higher potency and relatively fewer side effects, and its application in perioperative analgesia has attracted more and more attention. This article reviews the analgesic mechanism of esketamine and its application in perioperative analgesia, in order to provide reference for its application in perioperative analgesia.

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