切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 203 -208. doi: 10.3877/cma.j.issn.1674-0793.2025.03.011

综述

长链非编码RNA 乳腺癌抗雌激素耐药基因4 在常见肿瘤进展中的作用
安宁1, 陈健1, 张京伟2, 习一清1,()   
  1. 1. 430079 武汉,湖北省肿瘤医院 华中科技大学同济医学院附属肿瘤医院头颈外科
    2. 430071 武汉大学中南医院甲状腺乳腺外科
  • 收稿日期:2024-12-18 出版日期:2025-06-01
  • 通信作者: 习一清
  • 基金资助:
    湖北省肿瘤医院国家临床重点专科建设项目(HBCHBCC-B03)国家自然科学基金面上项目(8217113494)

Roles and mechanism of long non-coding RNA breast cancer anti-estrogen resistance 4 in common tumor development

Ning An1, Jian Chen1, Jingwei Zhang2, Yiqing Xi1,()   

  1. 1. Department of Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430079, China
    2. Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University,Wuhan 430071, China
  • Received:2024-12-18 Published:2025-06-01
  • Corresponding author: Yiqing Xi
引用本文:

安宁, 陈健, 张京伟, 习一清. 长链非编码RNA 乳腺癌抗雌激素耐药基因4 在常见肿瘤进展中的作用[J/OL]. 中华普通外科学文献(电子版), 2025, 19(03): 203-208.

Ning An, Jian Chen, Jingwei Zhang, Yiqing Xi. Roles and mechanism of long non-coding RNA breast cancer anti-estrogen resistance 4 in common tumor development[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2025, 19(03): 203-208.

长链非编码RNA 乳腺癌抗雌激素耐药基因4(lncRNA BCAR4)是一种在多种肿瘤中异常表达的分子,其首次在乳腺癌肿瘤细胞抗雌激素耐药中被发现,与肿瘤的发生、发展及耐药性密切相关。尽管BCAR4 作为预后生物标志物和治疗靶点的潜力在肿瘤中的作用已得到广泛证实,但其具体作用机制仍需进一步研究。本文详细分析了BCAR4 在乳腺癌、肝癌、结直肠癌、肺癌、食管癌和膀胱癌等中的表达模式及其对肿瘤生物学行为的影响,为其在肿瘤进展中的作用提供了全面视角,并为未来研究方向和临床应用提供了理论依据。

Long non-coding RNA breast cancer anti-estrogen resistance 4 (lncRNA BCAR4) was found in the anti-estrogen resistance of breast cancer tumor cells for the first time.It has been identified with abnormal expression in various types of cancer, which is closely associated with tumor progression and drug resistance.Although its role in tumor development is widely recognized, the detailed molecular mechanisms remain to be further explored.This review analyzes the expression patterns of BCAR4 in a variety of cancers including breast cancer, liver cancer, colorectal cancer, lung cancer, esophageal cancer, and bladder cancer,and its impact on tumor biology, providing a comprehensive perspective on its role in tumor progression, and offering theoretical basis for future research directions and clinical applications.

图1 BCAR4 在泛癌中的表达与在乳腺癌不同亚型中的表达
图2 BCAR4 在细胞中的定位
图3 BCAR4 在常见肿瘤中的功能与相关分子
[1]
Chen Y, Li Z, Chen X, et al.Long non-coding RNAs: from disease code to drug role[J].Acta Pharm Sin B, 2021, 11(2): 340-354.
[2]
Wang B, Xu W, Cai Y, et al.The functional role of oncogenic lncRNA BCAR4 for cancer outcome[J].Curr Pharm Des, 2021,27(39): 4107-4113.
[3]
Cai Z, Wu Y, Ju G, et al.Role of BCAR4 in prostate cancer cell autophagy[J].Transl Androl Urol, 2021, 10(11): 4253-4261.
[4]
Schmitz SU, Grote P, Herrmann BG.Mechanisms of long noncoding RNA function in development and disease[J].Cell Mol Life Sci, 2016, 73(13): 2491-2509.
[5]
Yi Q, Liu Z, Zhang K, et al.The role of long non-coding RNA BCAR4 in human cancers[J].Hum Cell, 2021, 34(5): 1301-1309.
[6]
Weidle UH, Birzele F, Kollmorgen G, et al.Long non-coding RNAs and their role in metastasis[J].Cancer Genomics Proteomics,2017, 14(3): 143-160.
[7]
Siegel RL, Giaquinto AN, Jemal A.Cancer statistics, 2024[J].CA Cancer J Clin, 2024, 74(1): 12-49.
[8]
Xing Z, Lin A, Li C, et al.lncRNA directs cooperative epigenetic regulation downstream of chemokine signals[J].Cell, 2014, 159(5):1110-1125.
[9]
Zheng X, Han H, Liu GP, et al.LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism[J].EMBO J, 2017, 36(22): 3325-3335.
[10]
Wu T, Li X, Yan G, et al.LncRNA BCAR4 promotes migration,invasion, and chemo-resistance by inhibiting miR-644a in breast cancer[J].J Exp Clin Cancer Res, 2023, 42(1): 14.
[11]
Ye X, Liu Q, Qin X, et al.BCAR4 facilitates trastuzumab resistance and EMT in breast cancer via sponging miR-665 and interacting with YAP1[J].FASEB J, 2024, 38(7): e23589.
[12]
Godinho MF, Sieuwerts AM, Look MP, et al.Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer[J].Br J Cancer, 2010, 103(8): 1284-1291.
[13]
Godinho MF, Wulfkuhle JD, Look MP, et al.BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib[J].Br J Cancer, 2012, 107(6): 947-955.
[14]
Lazar DC, Avram MF, Romosan I, et al.Malignant hepatic vascular tumors in adults: characteristics, diagnostic difficulties and current management[J].World J Clin Oncol, 2019, 10(3): 110-135.
[15]
Wang A, Meng J, Liu H, et al.Long non-coding RNA BCAR4 promotes liver cancer progression by regulating proliferation,migration and invasion[J].Oncol Lett, 2020, 20(3): 2779-2787.
[16]
Zhang Y, Zhou H.LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR-1261[J].Int J Mol Med, 2020, 46(1): 159-166.
[17]
Liu C, Gui Z, An C, et al.STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-beta-catenin axis[J].Commun Biol, 2024, 7(1): 396.
[18]
Huang Y, Rao X, Luo Y, et al.The effect of targeted regulation of LATS2 by LncRNA BCAR4 on proliferation, migration and apoptosis of HCC cells[J].Am J Transl Res, 2021, 13(5): 4624-4631.
[19]
White MT, Sears CL.The microbial landscape of colorectal cancer[J].Nat Rev Microbiol, 2024, 22(4): 240-254.
[20]
Ouyang S, Zhou X, Chen Z, et al.LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer[J].Cancer Cell Int, 2019, 19: 72.
[21]
Ouyang S, Zheng X, Zhou X, et al.LncRNA BCAR4 promotes colon cancer progression via activating Wnt/beta-catenin signaling[J].Oncotarget, 2017, 8(54): 92815-92826.
[22]
Li X, Chen X, Fu C, et al.Long non-coding RNA BCAR4 promotes oxaliplatin resistance in colorectal cancer by modulating miR-484-3p/RAB5C expression[J].Chemotherapy, 2023, 68(3): 119-130.
[23]
Herbst RS, Morgensztern D, Boshoff C.The biology and management of non-small cell lung cancer[J].Nature, 2018,553(7689): 446-454.
[24]
Yang H, Yan L, Sun K, et al.lncRNA BCAR4 increases viability,invasion, and migration of non-small cell lung cancer cells by targeting glioma-associated oncogene 2 (GLI2)[J].Oncol Res, 2019,27(3): 359-369.
[25]
Li N, Gao W J, Liu NS.LncRNA BCAR4 promotes proliferation,invasion and metastasis of non-small cell lung cancer cells by affecting epithelial-mesenchymal transition[J].Eur Rev Med Pharmacol Sci, 2017, 21(9): 2075-2086.
[26]
Gong J, Zhang H, He L, et al.Increased expression of long noncoding RNA BCAR4 is predictive of poor prognosis in patients with non-small cell lung cancer[J].Tohoku J Exp Med, 2017, 241(1):29-34.
[27]
Waters JK, Reznik SI.Update on management of squamous cell esophageal cancer[J].Curr Oncol Rep, 2022, 24(3): 375-385.
[28]
Yan S, Xu J, Liu B, et al.Long non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway[J].Bioengineered, 2021, 12(1): 682-696.
[29]
Ke S, Fang M, Li R, et al.Downregulation of long noncoding RNA breast cancer anti-estrogen resistance 4 inhibits cell proliferation,invasion, and migration in esophageal squamous cell carcinoma by regulating the microRNA-181c-5p/LIM and SH3 protein 1 axis[J].Bioengineered, 2022, 13(5): 12998-13010.
[30]
Dyrskjot L, Hansel DE, Efstathiou JA, et al.Bladder cancer[J].Nat Rev Dis Primers, 2023, 9(1): 58.
[31]
Zhang R, Wang J, Jia E, et al.lncRNA BCAR4 sponges miR-370-3p to promote bladder cancer progression via Wnt signaling[J].Int J Mol Med, 2020, 45(2): 578-588.
[32]
Wang X, He H, Rui W, et al.Long non-coding RNA BCAR4 binds to miR-644a and targets TLX1 to promote the progression of bladder cancer[J].Onco Targets Ther, 2020, 13: 2483-2490.
[33]
Shui X, Zhou C, Lin W, et al.Long non-coding RNA BCAR4 promotes chondrosarcoma cell proliferation and migration through activation of mTOR signaling pathway[J].Exp Biol Med (Maywood),2017, 242(10): 1044-1050.
[34]
Ju L, Zhou YM, Yang GS.Up-regulation of long non-coding RNA BCAR4 predicts a poor prognosis in patients with osteosarcoma,and promotes cell invasion and metastasis[J].Eur Rev Med Pharmacol Sci, 2016, 20(21): 4445-4451.
[35]
Chen F, Mo J, Zhang L.Long noncoding RNA BCAR4 promotes osteosarcoma progression through activating GLI2-dependent gene transcription[J].Tumour Biol, 2016, 37(10): 13403-13412.
[36]
Wang Z, Wang L, Liang Z, et al.Long non-coding RNA BCAR4 promotes growth, invasion and tumorigenicity by targeting miR-2276 to upregulate MMP7 expression in glioma[J].Onco Targets Ther, 2019, 12: 10963-10973.
[37]
Zhou GR, Huang DP, Sun ZF, et al.Long non-coding RNA BCAR4 accelerates cell proliferation and suppresses cell apoptosis in gastric cancer via regulating MAPK/ERK signaling[J].Eur Rev Med Pharmacol Sci, 2020, 24(7): 3657-3664.
[38]
Cai Z, Wu Y, Li Y, et al.BCAR4 activates GLI2 signaling in prostate cancer to contribute to castration resistance[J].Aging(Albany NY), 2018, 10(12): 3702-3712.
[39]
Zou R, Chen X, Jin X, et al.Up-regulated BCAR4 contributes to proliferation and migration of cervical cancer cells[J].Surg Oncol,2018, 27(2): 306-313.
[1] 刘伟, 牛云峰, 安杰. LINC01232 通过miR-516a-5p/BCL9 轴促进三阴性乳腺癌的恶性进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 330-338.
[2] 郝金锦, 王欢欢, 郑少祥, 陈文亮. 脂联素在结直肠癌中的作用[J/OL]. 中华普通外科学文献(电子版), 2025, 19(01): 61-65.
[3] 严华悦, 刘子祥, 周少波. 磷酸烯醇式丙酮酸羧激酶-1在恶性肿瘤中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(06): 452-456.
[4] 龙朝辉, 陈丹, 王依杰, 瞿根义, 徐勇, 阳光, 黄文琳, 汤乘. 膀胱尿路上皮癌血管生成相关LncRNA预后评估模型的构建与分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(03): 315-322.
[5] 邓永豪, 曹嘉正. 长链非编码RNA与肾癌的关系及其在肾癌中的临床应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(03): 289-293.
[6] 张诚实, 陈荣荣, 秦二云, 张青, 刘明, 冯契靓, 赵云峰. 动态测定血浆长链非编码RNA SOX2-OT在COPD 相关性肺动脉高压患者中的临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(06): 895-900.
[7] 陈丽璇, 窦培宁, 肖扬. 干细胞治疗早发性卵巢功能不全的现状及未来展望[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(04): 239-248.
[8] 王向前, 李清峰, 陈磊, 丘文丹, 姚志成, 李熠, 吴荣焕. 姜黄素抑制肝细胞癌索拉非尼耐药作用及其调控机制[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 729-735.
[9] 孟煜凡, 李永政, 樊知遥, 展翰翔. 瘤内微生物在胰腺癌发病和演进中的作用机制及研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 577-582.
[10] 张瑜廉, 党韩寒, 张传鹏, 何昆, 陈鹏宇, 张昀昇, 王在, 张黎, 于炎冰. 创伤性脑损伤急性期细胞焦亡关键分子的竞争性内源性RNA调控网络构建与验证[J/OL]. 中华神经创伤外科电子杂志, 2025, 11(01): 5-16.
[11] 汪鹏飞, 程莹莹, 赵海康. 骨髓间充质干细胞改善神经病理性疼痛的机制探讨[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 230-234.
[12] 周振宇, 杨利君, 薛伟, 彭亮. 推拿治疗肠易激综合征的研究进展[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(02): 185-190.
[13] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[14] 宋奕霄, 陈曦, 张明杰, 王丽平, 庞亚昌, 徐卓明. 心肌血管微环境在先天性心脏病相关的慢性右心衰竭进展中的作用[J/OL]. 中华心脏与心律电子杂志, 2024, 12(04): 239-244.
[15] 汪和, 胡梦杰, 王天爱, 梅紫暄, 龚铖, 潘定宇, 李震. 新型减重药物在肥胖治疗中的应用进展[J/OL]. 中华肥胖与代谢病电子杂志, 2025, 11(01): 40-45.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?