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中华普通外科学文献(电子版) ›› 2026, Vol. 20 ›› Issue (03) : 187 -191. doi: 10.3877/cma.j.issn.1674-0793.2026.03.008

综述

胆道菌群改变与胆管癌关系的研究进展
张继越1, 刘志伟1, 崔健勇2, 陈强谱1,2,()   
  1. 1 256600 滨州,滨州医学院附属医院肝胆外科
    2 256600 滨州,滨州医学院附属医院临床营养科
  • 收稿日期:2025-09-01 出版日期:2026-06-01
  • 通信作者: 陈强谱
  • 基金资助:
    山东省省级临床重点专科学科建设基金项目(SLCZDZK-0701)

Research progress on the relationship between changes in the bile duct microbiota and cholangiocarcinoma

Jiyue Zhang1, Zhiwei Liu1, Jianyong Cui2, Qiangpu Chen1,2,()   

  1. 1 Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou 256600, China
    2 Department of Clinical Nutrition Surgery, Binzhou Medical University Hospital, Binzhou 256600, China
  • Received:2025-09-01 Published:2026-06-01
  • Corresponding author: Qiangpu Chen
引用本文:

张继越, 刘志伟, 崔健勇, 陈强谱. 胆道菌群改变与胆管癌关系的研究进展[J/OL]. 中华普通外科学文献(电子版), 2026, 20(03): 187-191.

Jiyue Zhang, Zhiwei Liu, Jianyong Cui, Qiangpu Chen. Research progress on the relationship between changes in the bile duct microbiota and cholangiocarcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2026, 20(03): 187-191.

胆管癌是胆道系统的一种高度恶性肿瘤,具有侵袭性强、预后差、发病机制复杂的特点。近年来,随着高通量测序技术的发展,胆道菌群的变化在胆管癌的发生、发展和诊断中的作用受到了广泛关注。本文从胆管癌发病时胆道菌群的具体变化、胆道菌群改变影响胆管癌发生发展的机制、胆道菌群干预在胆管癌防治中的价值几个方面进行综述,以期为胆管癌的预防及治疗策略开拓新的方向。

Cholangiocarcinoma (CCA) is a highly malignant tumour of the biliary tract system, characterised by its aggressive nature, poor prognosis, and complex pathogenesis. In recent years, particularly with the advancements in high-throughput sequencing technology, the role of changes in the biliary tract microbiota in the occurrence, development, and diagnosis of CCA has garnered significant attention. This review examines the specific changes in the biliary tract microbiota associated with CCA, underlying the mechanisms by which alterations in the biliary tract microbiota drive the development and progression of CCA, and the potential value of biliary tract microbiota intervention in the prevention and treatment of CCA. The aim is to explore new directions for the prevention and treatment strategies of CCA.

图1 胆道菌群改变促进胆管癌发生的可能机制 A.胆汁酸代谢紊乱;B.微生物介导的炎症反应促进肿瘤发生;C.微生物群对肿瘤免疫微环境的影响
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