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53 Articles
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  • 1.
    Evaluation of efficacy of thermal ablation in the treatment of papilary thyroid carcinoma
    Hui Zhao, Huanjie Chen, Shujian Wei, Xiangfeng Lin, Ke Zhang, Haitao Zheng
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (05): 346-348. DOI: 10.3877/cma.j.issn.1674-0793.2020.05.006
    Abstract (63) HTML (0) PDF (1620 KB) (1)
    Objective

    To investigate whether thermal ablation can be used in operable papillary thyroid carcinoma (PTC) patients by analyzing the recurrence and reoperation cases of PTC after thermal ablation.

    Methods

    The data of twenty-three patients undergoing surgery after thermal ablation in Yuhuangding Hospital of Medical College of Qingdao University were retrospectively analyzed from May 2015 to August 2019. Fine needle aspiration (FNA) was performed in all patients before thermal ablation treatment in other hospitals, twenty cases were diagnosed as PTC and three cases was not excluded after biopsy. Fifteen cases underwent radical thyroidectomy, one underwent modified radical resection of lateral cervical lymph nodes, and seven cases underwent lobectomy due to compression of recurrent nodules.

    Results

    The pathology of paraffin after reoperation showed that 56.52% (13/23) had cancer cells, 43.47% (10/23) had no cancer cells, and 30.43% (7/23) had central lymph node metastasis. New PTC nodules were found on the opposite side of ablation in two cases.

    Conclusions

    Thermal ablation of PTC can’t completely deal with the primary lesions or achieve a radical effect. Thermal ablation is not recommended for PTC patients for whom surgical treatment is feasible.

  • 2.
    Therapeutic strategies of axillary treatment of early breast cancer patients with positive sentinel lymph nodes: A systematic review and Meta-analysis of clinical randomized controlled trials
    Jianghua Zhang, Haifeng Wang, Peizhong Shang, Chen Zhao, Runling Nan, Bing Liu, Ana Nie, Wei Zhang, Wei Hu
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (05): 388-394. DOI: 10.3877/cma.j.issn.1674-0793.2020.05.019
    Abstract (40) HTML (0) PDF (1938 KB) (0)
    Objective

    To systemically evaluate the prognosis value of different therapeutic strategies of axillary treatment of early breast cancer patients with positive sentinel lymph nodes (SLN).

    Methods

    From the establishment of the database to March 2020, PubMed, EMBASE, web of science, the Cochrane Library ClinicalTrials.gov, CNKI, VIP and Wanfang databases were retrieved for all the clinical randomized controlled trials (RCT) about comparative axillary lymph node dissection (ALND) and non-ALND in the treatment of early breast cancer patients with positive SLN. Meta-analysis were performed using Review-Manager 5.3 software after screening for inclusion, extraction, and quality assessment.

    Results

    A total of 5 clinical RCTs were finally included. For early breast cancer patients with positive SLN, the locoregional recurrence rate (RR=1.12, 95% CI: 0.76-1.65, P=0.56), overall survival (HR=0.91, 95% CI: 0.77-1.09, P=0.31) and disease-free survival (HR=1.00, 95% CI: 0.87-1.15, P=1.00) had no significant differences between patients who only receive SLN biopsy and patients who received further ALND. Patients who only received SLN biopsy had lower rate of lymphedema (RR=0.41, 95% CI: 0.27-0.63, P<0.001).

    Conclusion

    ALND had no significant impact on the prognosis of early breast cancer patients with positive SLN, with lower incidence of postoperative complications.

  • 3.
    Correlation between thyroid stimulating hormone receptor mutations and differentiated thyroid cancer: A systematic review
    Dongzhu Da, Zhi Long, Qian Wang, Gaoang Qiao, Jun Liu
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (05): 394-400. DOI: 10.3877/cma.j.issn.1674-0793.2020.05.020
    Abstract (52) HTML (0) PDF (1675 KB) (0)
    Objective

    To systematically evaluate the mutations of thyroid stimulating hormone receptor (TSHR) genes in patients with differentiated thyroid cancer (DTC).

    Methods

    A computerized literature search was carried out in PubMed, Web of Science, Cochrane Library, CNKI and Wanfang Data to identify all relevant cases of TSHR gene mutations in DTC patients. The search time period was from the establishment of the database to April 4, 2020. The relevant data extracted from the literature were analyzed, and the TSHR gene mutation profile of DTC patients was obtained.

    Results

    A total of 27 studies were included, including 395 DTC tissue samples. TSHR mutations were found in 10.38% (41/395) of DTC tissue samples, of which 92.68% mutations occurred in exon 10. M453T had the highest mutation frequency (6/37, 16.22%), followed by F458S (4/37, 10.81%). In addition, in 50 cases of DTC describing thyroid function, TSH mutations occurred in 81.82% (18/22) tissue samples with hyperthyroidism/subclinical hyperthyroidism, which was significantly higher than 10.71% (3/28) of normal thyroid function.

    Conclusions

    TSHR mutations in DTC are not uncommon, especially at low TSH levels. TSHR mutations may be related to the occurrence of DTC, especially DTC with hyperthyroidism.

  • 4.
    Prognostic value of preoperative fibrinogen to albumin ratio combined with systemic inflammation response index in patients with resectable gastric cancer
    Zhengyuan Yan, Heng Zhang, Guangping Yin
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (04): 266-270. DOI: 10.3877/cma.j.issn.1674-0793.2020.04.007
    Abstract (72) HTML (0) PDF (1649 KB) (0)
    Objective

    To investigate the prognostic value of preoperative fibrinogen to albumin ratio (FAR) combined with systemic inflammation resonance index (SIRI) in patients with resectable gastric cancer (rGC).

    Methods

    From January 2014 to December 2016, 105 patients with rGC underwent radical gastrectomy were included, followed up to December 31, 2019 or patient’s death. The cut-off values for FAR and SIRI were determined by ROC curve. The clinicopathological characteristics of three different groups were compared, and the prognostic factors of rGC patients were analyzed.

    Results

    According to the cut-off values of FAR and SIRI, patients were divided into three groups: FAR-SIRI 2 score group (FAR≥0.08, and SIRI≥0.74), FAR-SIRI 1 score group (FAR<0.08, and SIRI≥0.74), FAR-SIRI 0 score group (SIRI<0.74). FAR-SIRI was related to sex, age, tumor diameter, TNM stage, carcinoembryonic antigen and tissue differentiation (all P<0.05). Cox regression multivariate analysis showed that age≥60 yearsold (HR=1.957, 95% CI: 1.015-3.773, P=0.045), TNM stage (P=0.047, 0.003), poor degree of tissue differentiation (HR=0.363, 95% CI: 0.172-0.764, P=0.008) and FAR-SIRI 2 score (HR=2.576, 95% CI:1.313-5.051, P=0.006) were independent risk factors that affected the prognosis of rGC patients.

    Conclusions

    FAR-SIRI can be used as an effective predictor for prognosis in rGC patients, and can guide individualized treatment. High FAR-SIRI indicates that patients have a poor prognosis.

  • 5.
    Comparative study of the model for end-stage liver disease and MELD-Na scores in evaluating the short-term prognosis of liver transplantation in patients with liver failure
    Yongtai Chen, Fengfeng Xu, Ming Wang, Jianyong Liu, Qiucheng Cai, Fang Yang, Yongbiao Chen, Yi Jiang
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (03): 195-199. DOI: 10.3877/cma.j.issn.1674-0793.2020.03.007
    Abstract (88) HTML (0) PDF (2016 KB) (0)
    Objective

    To discuss clinical value of the model for end-stage liver disease (MELD) and MELD-Na scores for predicting the short-term prognosis of liver transplantation in patients with liver failure.

    Methods

    The preoperative and intraoperative clinical data of 86 liver failure patients who underwent liver transplantation in the 900 Hospital of the Joint Logistics Team from January 2012 to December 2019 were collected in this retrospective analysis. Multivariate analysis were used to determine the risk factors of early death (within 3 months) after liver transplantation. The distinguishing ability of MELD and MELD-Na scores for early prognosis was evaluated by the receiver operating characteristic (ROC) curve, and the Youden index was used to determine the best cut-off value.

    Results

    Of the 86 patients, there were 21 patients (24.4%) of early death in the short-term after liver transplantation. Preoperative MELD score (P=0.001) and intraoperative blood transfusion volume (P<0.001) were independent risk factors of liver transplantation in patients with liver failure. The AUC of MELD and MELD-Na scores for predicting the short-term prognosis were 0.696 and 0.686 respectively, with no statistical significancebetween two AUCs (P=0.677). The early survival rates of MELD≥24.3 group and MELD<24.3 group were 51.7% (15/29) and 87.7% (50/57), respectively (P<0.001). The early survival rates of MELD-Na≥25.7 groupand MELD-Na < 25.7 group were 54.9% (17/31) and 87.3% (48/55), respectively (both P<0.001). When the MELD score and MELD-Na score increased, the mortality rate increased.

    Conclusion

    In predicting the early prognosis of liver failure patients undergoing liver transplantation, there is no significant difference between the MELD score and the MELD-Na score in predicting ability. MELD score and intraoperative blood transfusion are independent risk factors for early death.

  • 6.
    Application of intestinal fatty acid binding protein in the evaluation of gastrointestinal function and condition in severe acute pancreatitis
    Longhui Wang, Qunliang Liu, Yunpeng Zhou, Guozhi Sun, Ni Yang, Meng Wang
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (03): 211-213. DOI: 10.3877/cma.j.issn.1674-0793.2020.03.011
    Abstract (28) HTML (0) PDF (2061 KB) (0)
    Objective

    To study the significance of intestinal fatty acid binding protein (I-FABP) in the severity of gastrointestinal dysfunction and the assessment of disease severity in severe acute pancreatitis (SAP) patients.

    Methods

    From December 2016 to December 2018, thirty-four patients with SAP admitted to Qingdao Eighth Peoples Hospital were selected. Levels of serum I-FABP, procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count were collected at admission. The patients were scored for gastrointestinal dysfunction and Acute Physiological and Chronic Health Status Score Ⅱ (APACHEⅡ). The correlations between serum I-FABP level and the above markers were analyzed.

    Results

    The concentration of I-FABP at admission was (551±204) ng/L, the PCT concentration was (3.36±1.79) μg/L, the CRP concentration was (171±73) mg/L, and the white blood cell count was (14.47±4.09)×109/L, APACHE score was (12±5), and gastrointestinal function score was (10±2). There was positive correlation among the serum I-FABP concentration and the concentration of PCT, CRP, white blood cell count, APACHEⅡ score, and gastrointestinal function score (P<0.01), and r was 0.537, 0.662, 0.730, 0.716, and 0.686 respectively.

    Conclusion

    Serum I-FABP is correlated with serum inflammatory markers, APACHE Ⅱ and gastrointestinal function score, which is helpful to evaluating gastrointestinal dysfunction and severity of SAP.

  • 7.
    Value of preoperative levels of serum miR-20a and miR-17 in the prognosis assessment of patients with colorectal cancer
    Jiyun Chen, Shilin Zhou, Danli Xiong, Lingli Wang, Peifang Ma, Jingjing Zhang, Wanli Zhang, Yong Xiao, Yanfeng Niu
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (02): 107-110. DOI: 10.3877/cma.j.issn.1674-0793.2020.02.007
    Abstract (30) HTML (0) PDF (908 KB) (0)
    Objective

    To investigate the value of preoperative levels of serum miR-20a and miR-17in the evaluation of adverse prognosis of patients with colorectal cancer.

    Methods

    From August 2013 to February 2016, seventy-three patients with colorectal cancer in Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology were selected as case group, and the serum samples were collected before operation, and 1 week, 1 month, 3 months after operation. Serum specimens of 81 healthy persons as control group were collected during the same period. According to the average level of miR-20a and miR-17 expression detected by fluorescent quantitation PCR, they were divided into high expression group and low expression group and survival analyzed by Kaplan-Meier method. Cox proportional hazard regression model was used to screen the influencing factors of poor prognosis. The diagnostic efficacy of miR-20a and miR-17 in the poor prognosis of colorectal cancer was analyzed by ROC curve.

    Results

    The serum levels of miR-20a and miR-17 in the case group decreased after operation (P<0.05), and the levels of each detection point were higher than those in the control group (P<0.05). Differentiation (HR=1.462, 95% CI: 1.096-1.951), TNM stage (HR=1.642, 95% CI: 1.339-2.014), preoperative serummiR-20a level (HR=1.575, 95% CI: 2.035-3.652) and miR-17 level (HR=2.491, 95% CI: 2.131-2.914) were independent risk factors affecting the poor prognosis of colorectal cancer patients (all P<0.001). The 3-year overall survival rate of preoperative patients with high expression of serum miR-20a and miR-17 was lower (22.0% vs 78.3%, 21.3% vs 73.1%, P<0.05), and the area under the curve for predicting poor prognosis of patients with colorectal cancer was 0.955, the sensitivity was 97.6%, and the specificity was 91.2%.

    Conclusions

    The high expression of serum miR-20a and miR-17 in patients with colorectal cancer before operation is related to poor prognosis. Preoperative detection is helpful to improving the clinical outcomes of patients with high risk of poor prognosis.

  • 8.
    Clinical efficacy and safety of complete mesocolic excision in the treatment of colon cancer
    Shaoyong Wang, Zhongmin Zhang, Guanghui Wang
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (02): 154-160. DOI: 10.3877/cma.j.issn.1674-0793.2020.02.019
    Abstract (26) HTML (0) PDF (1487 KB) (0)
    Objective

    To evaluate the safety, sample quality and long-term prognosis of complete mesocolic excision (CME) for colorectal cancer.

    Methods

    The relevant documents published in PubMed, ScienceDirect, Cochrane, Scopus, CNKI and Wanfang databases were searched by computer from the establishment of the database to December 2018. The results of safety, quality and long-term survival were extracted.

    Results

    A total of 8 914 patients from 15 studies were included in this Meta-analysis. Compared with non-complete mesocolic excision (NCME) group, CME group had more complications (RR=1.23, 95% CI: 1.08-1.40), more lymph nodes (WMD=8.42, 95% CI: 4.71-12.13), longer distance from tumor to high ligation of blood vessels (WMD=18.43, 95% CI: 16.18-20.69), larger area of mesentery (WMD=35.07, 95% CI: 12.78-57.36). The 3-, 5- year survival rates of the patients in CME group were both higher (HR=0.72, 95% CI: 0.61-0.86; HR=0.55, 95% CI: 0.42-0.73; both P<0.01).

    Conclusion

    CME can effectively improve the quality of surgical specimens and prolong the long-term survival rate, but the incidence of surgical complications is high, so the safety of operation should be concerned.

  • 9.
    Study on the value of circulating tumor cells detection in the evaluation of chemotherapy efficacy of advanced breast cancer
    Qiuchen Jiang, Dawei Yang, Panpan Xie, Wei Zhang, Yongrui Yang, Zhaoqing Cui
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (01): 19-22. DOI: 10.3877/cma.j.issn.1674-0793.2020.01.006
    Abstract (31) HTML (0) PDF (1469 KB) (0)
    Objective

    To investigate the value of circulating tumor cells (CTC) in evaluating the efficacy of chemotherapy in patients with advanced breast cancer.

    Methods

    Fifty patients with advanced breast cancer diagnosed in the Breast Center of Liaocheng Peoples Hospital from July 2016 to June 2018 were selected. Negative enrichment, immunocytochemistry CD45 staining and ?uorescence in situ hybridization (FISH) was used to identify, enumerate and characterize CTC during chemotherapy of advanced breast cancer patients, and the data of imaging and serological indexes were collected to compare the changes of CTC number during chemotherapy of patients and to compare with imaging and serological indexes.

    Results

    For the first time, there were 18 cases (36.0%) with CTC count 5, 28 cases (56.0%) with CTC count 1, and 4 cases (8.0%) with no CTC. The number of CTC was decreased in 32 cases and increased in 18 cases. The changes of CTC and imaging indicators were basically the same, and there was no significant difference between the changes of CTC count and imaging indicators in evaluating disease changes (kappa=0.65, χ2=0.125, P=0.724). The changes of serological indicators in the development of advanced breast cancer were statistically significant compared with those of imaging CEA (kappa=0.19, χ2=4.267, P=0.039), CK19 (kappa=0.16, χ2=6.667, P=0.010), CA15-3 (kappa=0.01, χ2=4.500, P=0.034).

    Conclusion

    CTC counts have certain clinical value in predicting the disease progression of patients with advanced breast cancer, and changes in CTC counts are more sensitive than serological indicators in predicting the risk of disease progression for patients with advanced breast cancer.

  • 10.
    Evaluation of efficacy of different surgical methods in the treatment of secondary splenic cystic hydatidosis
    Tuergan Talaiti·, Ruiqing Zhang, Yingmei Shao, Bo Ran, Tiemin Jiang, Aji Tuerganaili·
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (01): 39-41. DOI: 10.3877/cma.j.issn.1674-0793.2020.01.011
    Abstract (42) HTML (0) PDF (1417 KB) (0)
    Objective

    To analyze the difficulties, risks and prognosis of splenectomy, subtotal cystectomy and classic endocystectomy for the treatment of secondary splenic cystic hydatidosis.

    Methods

    The clinical data of seventy-one patients with secondary splenic cystic hydatidosis who underwent surgical treatment in the First Affiliated Hospital of Xinjiang Medical University from January 2007 to January 2017 were retrospectively analyzed. Among them, 26 patients received splenectomy (group A), 26 patients received subtotal cystectomy (group B), and 19 patients received clssic endocystectomy (group C). The intraoperative condition, postoperative recovery, postoperative residual complications and recurrence were observed and compared.

    Results

    Group A had the greatest intraoperative blood loss, longest postoperative anal exhaust time, catheter time, hospital stay, and highest hospital costs. However, intraoperative blood loss, postoperative catheter time, length of stay were shorter, and hospitalization cost were the lowest in group B (all P<0.05). After 2.5-12.5 years of follow-up, the incidence of postoperative complications in both group A and B was 3.85% (1/26), with no recurrence. The incidence of postoperative complications in group C was 21.05% (4/19), and the recurrence rate was 15.79% (3/19). The incidence of postoperative complications in the three groups was not statistically significant (χ2=4.62, P=0.090), but the recurrence rate in group C was significantly higher than that in the other two groups (χ2=8.28, P=0.016).

    Conclusions

    On the premise of strictly grasping the indications of operation, it is safe and the first choice to treat the secondary echinococcosis of spleen with subtotal resection of external capsule. The patients recover quickly after operation with low complication rates and hospitalization costs.

  • 11.
    Application of self-designed scoring criteria in the evaluation of thyroid nodules
    Guang Luo, Lishan Luo, Chen Wu
    Chinese Archives of General Surgery(Electronic Edition) 2020, 14 (01): 52-54. DOI: 10.3877/cma.j.issn.1674-0793.2020.01.015
    Abstract (25) HTML (0) PDF (1367 KB) (0)
    目的

    应用术中解剖甲状腺结节自设评分标准,分析甲状腺结节的良恶性可能,评估甲状腺结节术中自设评分的诊断价值。

    方法

    选取2018年1月至12月在广东药科大学附属第一医院因甲状腺结节性质待查、恶性肿瘤、良性结节等行甲状腺手术治疗的患者共173例,以术后石蜡切片病理作为"金标准",分析评估术中解剖甲状腺结节自设评分标准的诊断价值。

    结果

    173例患者共238个结节均经术中冰冻病理及术后石蜡切片病理诊断。评分≤1分(39个)及>4分(67个)的结节与石蜡病理结果的符合率达到100.00%;评分为2、3及4分时,与术中冰冻病理结果符合率分别为87.50%、87.23%、94.34%,与术后石蜡切片病理结果的符合率则分别为81.25%、82.98%、92.45%。

    结论

    我们设计的甲状腺结节术中评分标准是准确性高、相对客观、简单易学,能够有效筛选出阳性结节,降低漏诊率,帮助术中决策,是一个可靠的诊断方法。

  • 12.
    Quality evaluation of non-rigid subtraction technique in CT dynamic enhancement scanning of liver
    Zi Yan, Huasong Cai, Manshi Hu, Liqin Wang, Shiting Feng, Meng Wang
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (06): 459-462. DOI: 10.3877/cma.j.issn.1674-0793.2019.06.009
    Abstract (25) HTML (0) PDF (2328 KB) (0)
    Objective

    To evaluate the quality of non-rigid subtraction technique in CT dynamic enhancement scanning of liver.

    Methods

    The image data of fifty patients undergoing CT dynamic enhancement scanning of liver were retrospectively collected from December 2018 to February 2019 in the First Affiliated Hospital of Sun Yat-sen University. The subtraction images were obtained by non-rigid subtraction technique. The image quality before and after subtraction was evaluated. Qualitative evaluation included image artifacts and anatomical mismatch degree. The CT value of each blood vessel (abdominal aorta, right hepatic artery, left hepatic artery, portal vein trunk, right portal vein branch, and left portal vein branch) before and after the subtraction were measured quantitatively in the arterial and portal vein phases, mixed linear effect model and fitting equation were used to evaluate the fitting degree of CT value curve of each blood vessel before and after subtraction.

    Results

    There were no obvious artifacts caused by anatomical mismatch of the images after non-rigid subtraction, and the consistency of three surveyors was high (ICC=0.844,P<0.001). Subtraction technique could reduce the CT value of each blood vessel to a certain extent, and there was no interaction with enhancement phase. The CT values of each blood vessel before and after subtraction showed the same trend in both late arteries and the CT value curve was consistent.

    Conclusion

    Non-rigid subtraction technique can be applied to CT dynamic enhancement scanning of liver to obtain high quality images.

  • 13.
    A pilot study of magnetic resonance image fusion technology in the evaluation of anal fistula
    Xinwen Li, Meng Wang, Huasong Cai, Bingqi Shen
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (06): 480-484. DOI: 10.3877/cma.j.issn.1674-0793.2019.06.013
    Abstract (14) HTML (0) PDF (3428 KB) (0)
    Objective

    To get the fusion image of T2WI and T2WI-FS sequence by applying the image fusion technology, and evaluate the advantages in anal fistulas and surrounding structures.

    Methods

    From June 2016 to June 2018, twenty-nine patients with anal fistula were collected prospectively in the First Affiliated Hospital, Sun Yat-sen University. All the patients received anal magnetic resonance imaging (MRI) examination. T2WI and T2WI-FS images were used to generate fusion images (T2WI-Fusion). The discriminability of fistula, perianal sphincter, and perianal fat in T2WI, T2WI-FS, and T2WI-Fusion images was quantified with Fisher’s scoring algorithm. For subjective visual image assessment by researchers, five-point scale scores were determined using a modified double-stimulus continuous quality-scale (DSCQS) test to evaluate T2WI-FS, T2WI, enhanced axial 3D-volumetric interpolated breath-hold examination (3D-VIBE), and T2WI-Fusion sequence images.

    Results

    Mean Fisher scores for fistulas vs sphincters obtained from T2WI-Fusion images (value=6.46) were significantly higher than those from T2WI images (value=3.31) (P<0.001). Mean Fisher scores for sphincters vs fat from T2WI-Fusion images (value=10.61) were significantly higher than those from T2WI-FS images (value=2.45) (P<0.001). T2WI-Fusion images showed better whole anal fistula and sphincter discriminability than that of T2WI-FS, T2WI and enhanced 3D-VIBE images (P<0.001).

    Conclusions

    MRI fusion technology combines the advantages of the T2WI and T2WI-FS images without increasing scan sequence and scan time. This technology is easy to operate and timesaving, and can significantly increase the anal fistula and sphincter discriminability and improve the imaging quality.

  • 14.
    Advances in the application of model for end-stage liver disease and MELD-Na scores in liver transplantation
    Yongtai Chen, Ruisheng Ke, Qiucheng Cai, Lizhi Lyu, Yongbiao Chen, Yi Jiang
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (06): 488-491. DOI: 10.3877/cma.j.issn.1674-0793.2019.06.016
    Abstract (36) HTML (0) PDF (1669 KB) (0)

    The model for end-stage liver disease (MELD) is considered to be a good predictor of disease status in patients with end-stage liver disease and has been used for organ distribution in liver transplantation. This article briefly describes the relationship between MELD, MELD-Na score and the mortality of patients waiting for liver transplantation, the intraoperative blood transfusion, the survival, complications, and re-transplantation after liver transplantation.

  • 15.
    Application of several medical imageology tools in nutritional assessment
    Qiang Wei, Qiangpu Chen, Yanmin Lu
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (05): 341-344. DOI: 10.3877/cma.j.issn.1674-0793.2019.05.002
    Abstract (25) HTML (0) PDF (830 KB) (0)
  • 16.
    Values of neutrophil/lymphocyte count ratio, platelet/lymphocyte count ratio combined with carbohydrate antigen 19-9 in the early diagnosis and prognosis evaluation of colon cancer
    Xujuan Ye, Lan Yao, Shicheng Liu, Hongmei Dai
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (04): 274-278. DOI: 10.3877/cma.j.issn.1674-0793.2019.04.004
    Abstract (51) HTML (0) PDF (833 KB) (0)
    Objective

    To investigate the value of neutrophil/lymphocyte count ratio (NLR), platelet/lymphocyte count ratio (PLR) combined with carbohydrate antigen 19-9 (CA19-9) in the early diagnosis and prognosis evaluation of colon cancer.

    Methods

    From May 2015 to March 2017, one hundred and eighty-nine patients with colon cancer admitted to the Second People’s Hospital of Yibin City were selected as colon cancer group, and 72 healthy volunteers were selected as control group. All the subjects underwent routine blood tests and NLR and PLR were calculated, serum CA19-9 level was detected by electrochemiluminescence, and the receiver operating characteristic curve (ROC) was used to analyze the diagnostic efficiency of NLR, PLR and CA19-9 for colon cancer. According to the results of NLR, PLR, CA19-9 and combined detection, the patients were divided into positive group and negative group. Kaplan-Meier method was used to analyze the application value of different detection indicators in prognosis evaluation of patients with colon cancer.

    Results

    Compared with the control group, the NLR, PLR and CA19-9 levels in colon cancer group were significantly higher (P<0.05). ROC analysis showed that the area under curue (AUC) of NLR was 0.787, the sensitivity 62.96%, the specificity 79.17%, and the accuracy 67.43%. The AUC of PLR was 0.776, the sensitivity 65.61%, the specificity 76.39%, and the accuracy 68.58%. The AUC of CA19-9 was 0.735, the sensitivity 61.90%, the specificity 84.72%, and the accuracy 68.20%. The sensitivity of the three combined test was 91.01%, the specificity was 97.22%, the accuracy was 92.72%; the combined test was significantly higher than single tests (P<0.05). Kaplan-Meier analysis showed that the overall survival (OS) of NLR, PLR, CA19-9 and the combined tests positive group were significantly lower than those of the negative group (P<0.05), while the combined HR value was the highest, which was 2.188 (χ2=15.167, P<0.001, 95%CI=1.310-3.656).

    Conclusion

    NLR and PLR combined with CA19-9 test can improve the sensitivity and accuracy of early diagnosis of colon cancer, and the three combined tests have important guiding significance for prognosis evaluation of colon cancer patients.

  • 17.
    Reticular Meta-analysis of the efficacy evaluation of different surgical methods in the treatment of chronic anal fissure
    He Huang, Yongqiang Xiong, Hao Chen, Hui Liu, Chenqiang Yan
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (02): 161-168. DOI: 10.3877/cma.j.issn.1674-0793.2019.02.017
    Abstract (16) HTML (1) PDF (1260 KB) (0)
    Objective

    To evaluate the clinical effect of five surgical methods on chronic anal fissure.

    Methods

    Randomized controlled clinical trials of five surgical treatments for chronic anal fissure were performed by searching Chinese and foreign literature databases and related academic websites, including traditional anal fissure resection, longitudinal and transverse suture, modified longitudinal and transverse suture, and resection+internal/external sphincterotomy. The literature was screened according to the inclusion and exclusion criteria and data were extracted. The quality of the literature was assessed using the Jadad tool, Stata and GeMTC software.

    Results

    A total of twenty one randomized controlled clinical trials, 5 surgical procedures, and 2 430 participants were included. Reticular Meta-analysis showed that the cure rates of anal fissure resection+internal/external sphincterotomy were higher than those of traditional anal fissure resection. OR values were 2.27 (95%CI=1.14-4.36) and 3.26 (95%CI=1.67-6.75), respectively. The incidence of complications was the highest in longitudinal and transverse suture and traditional anal fissure resection, the lowest in resection+internal sphincterotomy.

    Conclusion

    In the evaluation of effectiveness and complication evaluation, the clinical effect of anal fissure resection + internal sphincterotomy is superior to the other 4 surgical methods.

  • 18.
    Sentinel lymph node micrometastasis and risks of breast cancer recurrence: a systematic review and meta analysis
    Denghui Wei, Zhihong Xu, Lili Xie, Hui Han, Shunguo Lin, Chunsen Xu
    Chinese Archives of General Surgery(Electronic Edition) 2019, 13 (01): 80-84. DOI: 10.3877/cma.j.issn.1674-0793.2019.01.018
    Abstract (22) HTML (0) PDF (886 KB) (0)
    Objective

    To systemically evaluate the recurrence related event rate (RRER) of breast cancer with sentinel lymph node micrometastasis (SLN MIC) without axillary lymph node dissection (ALND).

    Methods

    Databases such as PubMed, EMBASE, WanFang Data, CNKI and CBM were searched comprehensively for studies about SLN for breast cancer from foundation to May 1st, 2018. On the basis of the inclusion and exclusion criteria, extracting data, assessing methodological quality and analyzing results was achieved. RevMan 5.2 was used to carry out statistical analyses.

    Results

    A total of six studies, including 3 prospective observational studies and 3 retrospective studies involving 1 730 patients of whom 370 had SLN MIC and 1 360 had negative SLN (-), were qualified for final analysis. The odds ratio (OR) of RRER between group SLN MIC and group SLN (-) of breast cancer patients who didn’t performed ALND was 1.37 (95%CI: 0.72-2.59, I2=47%, P=0.34), without statistical differences. In addition, there was also no statistical difference in regional recurrence rate between group SLN MIC and group SLN(-) of breast cancer patients without ALND (OR=1.49, 95%CI: 0.75~2.97, I2=40%, P=0.26).

    Conclusion

    Compared with patients with negative SLN, SLN MIC does not increase the risk of recurrence in breast cancer patients without ALND.

  • 19.
    Predictive value of modified early warning score for closed abdominal trauma
    Hong Sun, Huajie Bao, Jianliang Wang
    Chinese Archives of General Surgery(Electronic Edition) 2018, 12 (05): 342-345. DOI: 10.3877/cma.j.issn.1674-0793.2018.05.013
    Abstract (30) HTML (0) PDF (983 KB) (0)
    Objective

    To observe the clinical effect of modified early warning score (MEWS) in evaluating closed abdominal trauma.

    Methods

    From January 2008 to November 2017, one hundred and sixty patients with closed abdominal trauma admitted to the Fifth Peoples Hospital of Wuhu were enrolled. Clinical diagnosis and prognosis data were retrospectively analyzed. The MEWS system was used to evaluate the patients diagnosis (outpatient or specialist conservative treatment, ICU rescue, transfer operation), complications in the course of treatment and 30 days’ prognosis.

    Results

    Among the 160 patients, 64 cases (40.0%) were treated conservatively, 96 (60.0%) were admitted to ICU, and 34 (21.3%) underwent transfer operation. There were 16 cases with MEWS score >8. The rate of conservative treatment was significantly lower than that of other scores (except of MEWS score >6-8). The rate of rescue in ICU (100.0%) was significantly higher than that in other segments (except of MEWS score >6-8). The conversion rate was significantly lower than the MEWS score <3 and 3-4 segments. The prognosis in 30 d was good in 124 cases (77.5%), the MEWS score was (2.44±1.32), 36 (22.5%) with poor prognosis, and the MEWS score was 6.84±2.12. Twelve cases (7.5%) died, 16 (10.0%) were infected, 4 (2.5%) had multiple organ failure, and 4 cases (2.5%) suffered from stress ulcer. The ROC curve analysis showed that the MEWS score had a certain predictive value for poor prognosis in patients with closed abdominal trauma. Area under the curve was 0.919 (P<0.001, 95% CI=0.797-1.000), the cut-off value was 5.970, the sensitivity was 0.667, and the specificity was 0.986.

    Conclusion

    MEWS plays an important role in choosing triage protocols and evaluating prognosis of closed abdominal trauma, reducing complications and mortality, and improving the prognosis.

  • 20.
    Immediate breast reconstruction with acellular cadaveric dermis after nipple-areola complex–sparing mastectomy for breast cancer
    Lu Du, Jinchun Feng, Tao Wu, Shalie’er Tuluhong, Bin Wang, Liang Yang, Qian Zhao, Jinsihan Dilixiati, Wenting Xu, Liping Zhu
    Chinese Archives of General Surgery(Electronic Edition) 2018, 12 (05): 354-358. DOI: 10.3877/cma.j.issn.1674-0793.2018.05.016
    Abstract (43) HTML (0) PDF (1102 KB) (0)
    Objective

    To compare the short-term curative effect, complications and cosmetic result between immediate breast reconstruction and acellular cadaveric dermis-assisted immediate breast reconstruction after nipple-areola complex (NAC)–sparing mastectomy for breast cancer.

    Methods

    Between January 2015 and November 2017, a total of fifity-nine patients with breast cancer undergoing breast reconstruction in the Department of Breast Surgery, Affiliated Cancer Hospital, Xinjiang Medical University were included prospectively. Patients were randomly divided into two groups, 28 in the immediate breast reconstruction group (control group) and 31 in the acellular cadaveric dermis-assisted immediate breast reconstruction group (assisted group). The short-term curative effect, complications and cosmetic result between two groups were studied.

    Results

    All patients successfully completed the breast reconstruction. The incidence rate of skin flap necrosis of the control group was 21.4% (6/28), the assisted group 25.8% (8/31); there was no statistically significant difference between the two groups (χ2=0.156, P=0.693). All patients were evaluated the surgical results six months after the operation. The satisfaction rate of control group was 63.0% (17/27) and the assisted group was 86.7% (26/30) , with statistically significant difference (Z=-2.287, P=0.022). The incidence of seroma in the control group was 28.6% (8/28), and the assisted group 32.3% (10/31), with no statistically significant difference between the two groups (χ2=0.094, P=0.759). Other complications such as allergies and rejection did not occur.

    Conclusion

    Therapeutic effect and complications are similar between the two reconstruction methods without postoperation complication differences, but the cosmetic result of acellular cadaveric dermis-assisted immediate breast reconstruction group is better.

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