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中华普通外科学文献(电子版) ›› 2008, Vol. 02 ›› Issue (04) : 271 -274. doi: 10.3877/cma.j.issn.1674-0793.2008.04.005

论著

胃癌中血小板衍生内皮细胞生长因子的表达与微血管生成
葛敦钧,1, 胡希宏1, 胡立明1   
  1. 1.322100 东阳,浙江省东阳市人民医院普外科
  • 收稿日期:2007-11-22 出版日期:2008-08-01
  • 通信作者: 葛敦钧

The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma

Dun-jun GE,1, Xi-hong HU1, Li-ming HU1   

  1. 1.The People's Hospital of DongYang, DongYang 322100,China
  • Received:2007-11-22 Published:2008-08-01
  • Corresponding author: Dun-jun GE
引用本文:

葛敦钧, 胡希宏, 胡立明. 胃癌中血小板衍生内皮细胞生长因子的表达与微血管生成[J/OL]. 中华普通外科学文献(电子版), 2008, 02(04): 271-274.

Dun-jun GE, Xi-hong HU, Li-ming HU. The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(04): 271-274.

目的

研究探讨胃癌组织中血小板衍生内皮细胞生长因子(PD-ECGF)的表达及微血管密度(MVD)与胃癌生物学行为和血管生成的关系。

方法

应用免疫组化ElivisionTM 法检测52 份胃癌组织中PD-ECGF、CD34 的表达并测定MVD,回顾分析胃癌患者的临床病理资料。

结果

胃癌组织中PD-ECGF 的表达率为59.62%,平均MVD 为72.60±16.87;伴有淋巴结转移组、侵及浆膜或浆膜外组的PD-ECGF的阳性率及MVD 显著高于无淋巴结转移组、浸润深度未达浆膜层组,且Ⅲ期和Ⅳ期组的MVD 高于Ⅰ期和Ⅱ期组;PD-ECGF 阳性组的MVD高于阴性组。

结论

PD-ECGF 参与了胃癌的浸润和转移及血管生成,PD-ECGF 作为肿瘤抗血管治疗的靶点具有一定的价值。

Objective

To explore the relationship between the expression of platelet-derived endothelial cell growth factor(PD-ECGF) together with microvascular density (MVD) and biological behaviour and tumor angiogenesis in gastric carcinoma.

Methods

ElivisionTM immunohistochemical method was performed to detect the expression of PD-ECGF and CD34,evaluated the value of MVD in fifty-two gastric carcinoma specimens.Clinicopathologic materials of patients were assayed retrospectively.

Results

The positive expression of PD-ECGF was 59.62%, and the value of MVD was 72.60±16.87.The rates of expression and the value of MVD in the group with lymph node metastasis and the group with or exceed serosa invasion were higher than that without lymph node metastasis and without serosa invasion respectively. MVD in group of Ⅲ+Ⅳstage was significantly higher than that inⅠ+Ⅱstage.MVD in the PD-ECGF positive-expression group was significantly higher than that in negative-expression group.

Conclusion

PD-ECGF participates in the invasion and metastasis,angiogenesis of human gastric carcinoma.PD-ECGF can be selected asa target for tumor anti-angiogenesis treatment.

表1 胃癌组织中PD-ECGF的表达和MVD与临床病理特征的关系(例,
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