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中华普通外科学文献(电子版) ›› 2011, Vol. 05 ›› Issue (01) : 50 -53. doi: 10.3877/cma.j.issn.1674-0793.2011.01.016

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讲座与综述

经典Wnt信号通路在原发性肝癌发生中的作用
王玉1, 叶建明1   
  1. 1. 528403 中山,中山大学附属中山医院 中山市人民医院消化内科
  • 收稿日期:2010-08-26 出版日期:2011-02-01
  • Received:2010-08-26 Published:2011-02-01
引用本文:

王玉, 叶建明. 经典Wnt信号通路在原发性肝癌发生中的作用[J]. 中华普通外科学文献(电子版), 2011, 05(01): 50-53.

原发性肝癌(HCC)是世界第5大肿瘤,死亡率高,其发病率呈上升趋势。研究表明,多种信号通路参与了HCC的发生发展如p53信号通路、Rb信号通路、经典Wnt信号通路等[2]。Wnt基因家族编码蛋白的异常表达可引起经典Wnt信号通路的激活,进而导致核心因子β-catenin稳态并定位于核内,激活下游靶基因的转录,与肿瘤发生有关。了解该通路在HCC发生发展中的作用有重要意义。

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