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中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (05) : 393 -396. doi: 10.3877/cma.j.issn.1674-0793.2013.05.015

所属专题: 文献

综述

肝癌缺失基因1与原发性肝癌的研究进展
彭鹏1   
  1. 1. 524023 湛江,广东医学院2010级研究生
    2. 中山市人民医院肝胆外科
  • 收稿日期:2013-03-08 出版日期:2013-10-01

Research development of DLC-1 gene in hepatocellular carcinoma

Peng PENG1   

  1. 1. Graduate School of Guangdong Medical College, Zhanjiang 524023, China
  • Received:2013-03-08 Published:2013-10-01
引用本文:

彭鹏. 肝癌缺失基因1与原发性肝癌的研究进展[J]. 中华普通外科学文献(电子版), 2013, 07(05): 393-396.

Peng PENG. Research development of DLC-1 gene in hepatocellular carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(05): 393-396.

肝癌缺失基因-1(DLC-1)是从原发性肝癌组织中分离出来的一种肿瘤抑制基因。它在人类多种恶性肿瘤中表达缺失或下调,是近年来研究比较热门的肿瘤抑制基因之一。本文将对DLC-1基因的结构及生物学功能作一介绍,结合目前关于DLC-1在肝癌中的最新研究成果,探讨DLC-1基因在肝癌发生发展中的作用机制,并对DLC-1在肝癌中表达缺失的遗传学和表观遗传学机制进行了深入讨论。

Deleted in liver cancer 1(DLC-1), a tumor suppressor gene, is separated from primary liver cancer tissue. Its expression is down-regulated or absent in a variety of human malignant tumors and also a tumor suppressor gene hot in recent researches. This article will firstly introduce the structure and biological function of the DLC-1 gene, and then discuss the mechanism of the DLC-1 gene in the development of liver cancer, combined with the latest research achievements at present about DLC-1 in hepatocellular carcinoma. The last part is more in-depth discussions of the DLC-1 expression in HCC missing genetics and epigenetic mechanisms.

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