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中华普通外科学文献(电子版) ›› 2013, Vol. 07 ›› Issue (05) : 397 -399. doi: 10.3877/cma.j.issn.1674-0793.2013.05.016

所属专题: 文献

综述

线粒体自噬在肝相关疾病中的作用
王超臣1, 张培建1   
  1. 1. 225002 扬州大学第二临床医学院普通外科研究室
  • 收稿日期:2013-05-19 出版日期:2013-10-01
  • 基金资助:
    扬州市科技攻关项目(YZ2009051,YZ2010087)

Targeting mitophagy for the treatment of liver diseases

Chao-chen WANG1, Pei-jian ZHANG1   

  1. 1. General Surgery, Yangzhou No.1 People's Hospital, the Second Clinical Medical College, Yangzhou 225002, China
  • Received:2013-05-19 Published:2013-10-01
引用本文:

王超臣, 张培建. 线粒体自噬在肝相关疾病中的作用[J]. 中华普通外科学文献(电子版), 2013, 07(05): 397-399.

Chao-chen WANG, Pei-jian ZHANG. Targeting mitophagy for the treatment of liver diseases[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(05): 397-399.

细胞自噬是细胞依赖溶酶体的分解代谢过程,能降解受损蛋白、衰老或损伤的细胞器等细胞结构,来维持细胞内稳态。众所周知,线粒体调节异常是许多疾病的发病机制。本文主要探讨线粒体自噬在肝相关疾病如非酒精性脂肪肝病、肝癌和肝缺血再灌注损伤中的作用。

Autophagy is a lysosomal degradation pathway that can degrade bulk cytoplasm and superfluous or damaged organelles, such as mitochondria, to maintain cellular homeostasis. It is known that dysregulation of mitochondrial autophagy can cause pathogenesis of numerous human diseases. Here, we discuss the critical roles that mitochondrial autophagy plays in the pathogenesis of liver diseases such as non-alcoholic and alcoholic fatty liver, liver cancer, and hepatic ischemia reperfusion injury.

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